The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortality
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| Názov: | The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortality |
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| Autori: | Herrmann, Markus, Keppel, Martin H, Zelzer, Sieglinde, Alonso, Nerea, Cavalier, Etienne, Kleber, Marcus, Enko, Dietmar, Scharnagl, Hubert, Pilz, Stefan, März, Winfried |
| Zdroj: | Clinical Chemistry and Laboratory Medicine (CCLM). 63:208-219 |
| Informácie o vydavateľovi: | Walter de Gruyter GmbH, 2024. |
| Rok vydania: | 2024 |
| Predmety: | Vitamin D/analogs & derivatives, Male, Clinical Biochemistry, Cardiovascular Diseases/blood, vitamin D, functional deficiency, Sciences de la santé humaine, 03 medical and health sciences, 0302 clinical medicine, Laboratory medicine & medical technology, cardiovascular mortality, Vitamin D Deficiency/blood, Natriuretic Peptide, Brain, Humans, Human health sciences, Vitamin D, Cardiovascular Diseases/mortality, Aged, pro-brain natriuretic peptide (1-76), Biochemistry (medical), Middle Aged, Vitamin D Deficiency, 16. Peace & justice, 25-hydroxyvitamin D, Peptide Fragments, 3. Good health, Médecine de laboratoire & technologie médicale, Vitamin D/blood, Cardiovascular Diseases, Female, Natriuretic Peptide, Brain/blood, Vitamin D Deficiency/complications, Vitamin D Deficiency/epidemiology |
| Popis: | Objectives The role of vitamin D deficiency in cardiovascular disease (CVD) is controversial. Inherent biological and analytical limitations compromise the specificity of widely used 25-hydroxyvitamin D [25(OH)D] cut-offs. Simultaneous determination of 25(OH)D and 24,25-dihydroxyvitamin D [24,25(OH)2D] permits a functional assessment of vitamin D metabolism. The present study compared the associations of functional vitamin D deficiency and low vitamin D reservoirs with CVD mortality and CVD burden. Methods 25(OH)D, 24,25(OH)2D, the degree of coronary obstruction on angiography, high-sensitive cardiac troponin T (hs-cTnT), N-terminal brain natriuretic peptide (NT-proBNP), and 10-year CVD mortality were obtained from 2,456 participants of the LURIC (Ludwigshafen Risk and Cardiovascular Health) study. Results Neither low 25(OH)D concentrations nor functional vitamin D deficiency were associated with the number of atherosclerotic coronary arteries or the degree of coronary obstruction. Over a median follow-up of 9.9 years, 454 participants died (23.6 %) due to CVD. CVD mortality was doubled in individuals with 25(OH)D concentrations below the widely used cut-off for deficiency of Conclusions Vitamin D deficient individuals have markedly higher CVD mortality, but only marginally higher hs-cTnT concentrations. A higher prevalence of heart failure and higher NT-proBNP concentrations suggest a link between vitamin D deficiency and cardiac function. The traditional and metabolic assessment of vitamin D status showed comparable associations for the different parameters of cardiac health. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1437-4331 1434-6621 |
| DOI: | 10.1515/cclm-2024-0391 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38890759 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....3d2ee988dd51caafb13f20e2a594a44c |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Objectives The role of vitamin D deficiency in cardiovascular disease (CVD) is controversial. Inherent biological and analytical limitations compromise the specificity of widely used 25-hydroxyvitamin D [25(OH)D] cut-offs. Simultaneous determination of 25(OH)D and 24,25-dihydroxyvitamin D [24,25(OH)2D] permits a functional assessment of vitamin D metabolism. The present study compared the associations of functional vitamin D deficiency and low vitamin D reservoirs with CVD mortality and CVD burden. Methods 25(OH)D, 24,25(OH)2D, the degree of coronary obstruction on angiography, high-sensitive cardiac troponin T (hs-cTnT), N-terminal brain natriuretic peptide (NT-proBNP), and 10-year CVD mortality were obtained from 2,456 participants of the LURIC (Ludwigshafen Risk and Cardiovascular Health) study. Results Neither low 25(OH)D concentrations nor functional vitamin D deficiency were associated with the number of atherosclerotic coronary arteries or the degree of coronary obstruction. Over a median follow-up of 9.9 years, 454 participants died (23.6 %) due to CVD. CVD mortality was doubled in individuals with 25(OH)D concentrations below the widely used cut-off for deficiency of Conclusions Vitamin D deficient individuals have markedly higher CVD mortality, but only marginally higher hs-cTnT concentrations. A higher prevalence of heart failure and higher NT-proBNP concentrations suggest a link between vitamin D deficiency and cardiac function. The traditional and metabolic assessment of vitamin D status showed comparable associations for the different parameters of cardiac health. |
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| ISSN: | 14374331 14346621 |
| DOI: | 10.1515/cclm-2024-0391 |