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Added prognostic value of fat attenuation index and CT-derived fractional flow reserve over plaque burden in suspected CAD patients without standard modifiable risk factors

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Název: Added prognostic value of fat attenuation index and CT-derived fractional flow reserve over plaque burden in suspected CAD patients without standard modifiable risk factors
Autoři: Yu, Yang, Guo, Fuqian, Chen, Yicheng, Bao, Wenjun, Li, Caiying
Zdroj: African Health Sciences; Vol. 24 No. 3 (2024); 444-452
Informace o vydavateli: African Journals Online (AJOL), 2024.
Rok vydání: 2024
Témata: Coronary artery disease, CT-derived fractional flow reserve, fat attenuation index, plaque burden, standard cardiovascular risk factor, prognosis
Popis: Background: In this study, we aimed to investigate the added prognostic value of fat attenuation index (FAI) and CT-derivedfractional flow (CT-FFR) over plaque burden in suspected coronary artery disease (CAD) patients without standard modifiablerisk factors (SMuRFs). Methodology: A total of 260 consecutive suspected CAD subjects without SMuRFs who underwent first coronary computed tomography angiography (CCTA) were retrospectively collected. We calculated FAI, CT-FFR, and segment involvement score (SIS) from CCTA images. Cox regression models were used to assess the incremental prognostic value of FAI and CT-FFR. Results: During a median follow-up of 25.00 months, major adverse cardiovascular events (MACE) were observed in 40 (15.4%) patients. FAI ≥ −70.1, CT-FFR ≤ 0.80, and SIS ≥ 4.5 were associated with the increased rate of MACE (P < 0.0001). FAI did not provide incremental prognostic value over SIS (P = 0.169). Likewise, CT-FFR did not enhance risk prediction (P = 0.159). Combining FAI and CT-FFR added incremental prediction value and improved risk discrimination (P = 0.032; Absolute integrate discrimination improvement (IDI) = 0.070, P < 0.001). Conclusion: In suspected CAD patients without SMuRFs, neither FAI nor CT-FFR independently added incremental prognostic value over plaque burden. Combining FAI and CT-FFR had added prognostic value and improved cardiovascular risk stratification. Keywords: Coronary artery disease; CT-derived fractional flow reserve; fat attenuation index; plaque burden; standard cardiovascularrisk factor; prognosis.
Druh dokumentu: Article
Popis souboru: application/pdf
ISSN: 1729-0503
1680-6905
DOI: 10.4314/ahs.v24i3.49
Přístupová URL adresa: https://www.ajol.info/index.php/ahs/article/view/280082
Přístupové číslo: edsair.doi.dedup.....3d1e23c6b0dd2722dfec795f4c65edab
Databáze: OpenAIRE
Popis
Abstrakt:Background: In this study, we aimed to investigate the added prognostic value of fat attenuation index (FAI) and CT-derivedfractional flow (CT-FFR) over plaque burden in suspected coronary artery disease (CAD) patients without standard modifiablerisk factors (SMuRFs). Methodology: A total of 260 consecutive suspected CAD subjects without SMuRFs who underwent first coronary computed tomography angiography (CCTA) were retrospectively collected. We calculated FAI, CT-FFR, and segment involvement score (SIS) from CCTA images. Cox regression models were used to assess the incremental prognostic value of FAI and CT-FFR. Results: During a median follow-up of 25.00 months, major adverse cardiovascular events (MACE) were observed in 40 (15.4%) patients. FAI ≥ −70.1, CT-FFR ≤ 0.80, and SIS ≥ 4.5 were associated with the increased rate of MACE (P < 0.0001). FAI did not provide incremental prognostic value over SIS (P = 0.169). Likewise, CT-FFR did not enhance risk prediction (P = 0.159). Combining FAI and CT-FFR added incremental prediction value and improved risk discrimination (P = 0.032; Absolute integrate discrimination improvement (IDI) = 0.070, P < 0.001). Conclusion: In suspected CAD patients without SMuRFs, neither FAI nor CT-FFR independently added incremental prognostic value over plaque burden. Combining FAI and CT-FFR had added prognostic value and improved cardiovascular risk stratification. Keywords: Coronary artery disease; CT-derived fractional flow reserve; fat attenuation index; plaque burden; standard cardiovascularrisk factor; prognosis.
ISSN:17290503
16806905
DOI:10.4314/ahs.v24i3.49