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Harnessing aromatic properties for sustainable bio-valorization of lignin derivatives into flavonoids

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Bibliographic Details
Title: Harnessing aromatic properties for sustainable bio-valorization of lignin derivatives into flavonoids
Authors: Si-Yu Zhu, Na Li, Zhi-Hua Liu, Ying-Jin Yuan, Bing-Zhi Li
Source: Green Carbon, Vol 3, Iss 2, Pp 172-195 (2025)
Publisher Information: Elsevier BV, 2025.
Publication Year: 2025
Subject Terms: Flavonoids, Environmental sciences, Functionalization route, Biological lignin valorization, GE1-350, Enzyme engineering, Synthetic biology
Description: Lignin represents the most abundant renewable aromatic source, while flavonoids are aromatic natural compounds with various health-promoting properties and superior biological activities. The bioconversion of lignin derivatives into flavonoids holds promising potential for both lignin valorization and flavonoid synthesis. In this review, we prospect sustainable, atom-economic functionalization routes from lignin-derived aromatics to flavonoids by leveraging lignin’s inherent aromaticity. The representative flavonoid biosynthesis routes had first been elaborated from lignin derivatives in detail. The functionalization reactions involved in incorporating lignin derivatives into flavonoid structure were summarized to promote lignin bioconversion and yield flavonoids with desirable properties. Harnessing the powerful engineering strategies, such as synthetic biology, machine learning, metabolic regulation, boost the flavonoid production in microbial cell factories, enhancing lignin valorization. Overall, lignin functionalization routes for flavonoid biosynthesis hold promise to achieve the feasibility of lignin valorization and the production of flavonoids, contributing significantly to the sustainable bioeconomy.
Document Type: Article
Language: English
ISSN: 2950-1555
DOI: 10.1016/j.greenca.2024.11.005
Access URL: https://doaj.org/article/f57ce71ff2c64be7a5b4ed79d45bd9c6
Rights: CC BY NC ND
Accession Number: edsair.doi.dedup.....39a32d677f37e84776d081c15ce2d38c
Database: OpenAIRE
Description
Abstract:Lignin represents the most abundant renewable aromatic source, while flavonoids are aromatic natural compounds with various health-promoting properties and superior biological activities. The bioconversion of lignin derivatives into flavonoids holds promising potential for both lignin valorization and flavonoid synthesis. In this review, we prospect sustainable, atom-economic functionalization routes from lignin-derived aromatics to flavonoids by leveraging lignin’s inherent aromaticity. The representative flavonoid biosynthesis routes had first been elaborated from lignin derivatives in detail. The functionalization reactions involved in incorporating lignin derivatives into flavonoid structure were summarized to promote lignin bioconversion and yield flavonoids with desirable properties. Harnessing the powerful engineering strategies, such as synthetic biology, machine learning, metabolic regulation, boost the flavonoid production in microbial cell factories, enhancing lignin valorization. Overall, lignin functionalization routes for flavonoid biosynthesis hold promise to achieve the feasibility of lignin valorization and the production of flavonoids, contributing significantly to the sustainable bioeconomy.
ISSN:29501555
DOI:10.1016/j.greenca.2024.11.005