Prevalence and Recognition of Obstructive Sleep Apnea in Chinese Patients With Type 2 Diabetes Mellitus
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| Titel: | Prevalence and Recognition of Obstructive Sleep Apnea in Chinese Patients With Type 2 Diabetes Mellitus |
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| Autoren: | Ong, LHY, Lam, DCL, Ip, MSM, Lam, KSL, Lui, MMS, Lam, JCM |
| Quelle: | Chest. 138:1101-1107 |
| Verlagsinformationen: | Elsevier BV, 2010. |
| Publikationsjahr: | 2010 |
| Schlagwörter: | Blood Glucose, Male, Sleep Apnea, Polysomnography - methods, Polysomnography, Hong Kong - epidemiology, Diabetes Mellitus, Type 2 - blood - complications - epidemiology, Sleep Apnea, Obstructive - diagnosis - epidemiology - etiology, Obstructive - diagnosis - epidemiology - etiology, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes Mellitus, Prevalence, Humans, Retrospective Studies, Type 2 - blood - complications - epidemiology, Sleep Apnea, Obstructive, Middle Aged, Prognosis, 3. Good health, Diabetes Mellitus, Type 2, Blood Glucose - metabolism, Hong Kong, Female, Follow-Up Studies |
| Beschreibung: | Obstructive sleep apnea (OSA) is associated with disorders of glucose metabolism. Previous studies revealed a high prevalence of OSA among subjects with type 2 diabetes mellitus (DM). The aims of this study were to determine the prevalence of OSA and associated clinical factors in Chinese patients with DM.All records of the DM clinic at a teaching hospital in Hong Kong were screened between January 2007 and June 2008. Inclusion criteria for patients were Chinese, aged 18 to 75 years, with type 2 DM. Patients with unstable medical illnesses, gestational diabetes, or on renal replacement therapy were excluded.Of 3,489 records screened, 1,859 subjects were eligible. A random sample of 663 (mean age, 58.2 ± 10.8; mean BMI, 26.0 ± 4.6), except six with known OSA, were invited for polysomnography (PSG). Of 165 subjects on which PSG was performed, OSA was diagnosed (apnea-hypopnea index [AHI] ≥ 5.0/h) in 89 subjects (53.9%, median Epworth Sleepiness Scale, 6 [interquartile range 3, 10]). Fifty-four (32.7%) had moderate/severe OSA (AHI ≥ 15/h). The estimated OSA prevalence in this diabetic cohort was 17.5% (24.7% in men, 10.3% in women). Regression analysis identified that AHI was associated independently with higher BMI, advanced age, male sex, and higher diastolic BP (R(2) = 29.6%). The adjusted OR of requiring three or more antihypertensive drugs in moderate/severe OSA was 2.48 (95% CI, 1.05-5.87). No association between glycemic control (HbA1c) and sleep was identified.In conclusion, OSA is more prevalent in Chinese adults with DM than in the general population. A high index of suspicion for OSA in patients with DM is warranted, because they may not have overt daytime sleepiness. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.10-0596 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/20705796 http://journal.publications.chestnet.org/article.aspx?articleid=1045210 http://europepmc.org/abstract/MED/20705796 https://core.ac.uk/display/37962169 https://www.sciencedirect.com/science/article/abs/pii/S0012369210605867 https://pubmed.ncbi.nlm.nih.gov/20705796/ https://journal.publications.chestnet.org/article.aspx?articleid=1045210 http://hdl.handle.net/10722/139459 |
| Rights: | Elsevier TDM |
| Dokumentencode: | edsair.doi.dedup.....2cf0581d80d0c99d3421d1cc3b7ddfa6 |
| Datenbank: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Obstructive sleep apnea (OSA) is associated with disorders of glucose metabolism. Previous studies revealed a high prevalence of OSA among subjects with type 2 diabetes mellitus (DM). The aims of this study were to determine the prevalence of OSA and associated clinical factors in Chinese patients with DM.All records of the DM clinic at a teaching hospital in Hong Kong were screened between January 2007 and June 2008. Inclusion criteria for patients were Chinese, aged 18 to 75 years, with type 2 DM. Patients with unstable medical illnesses, gestational diabetes, or on renal replacement therapy were excluded.Of 3,489 records screened, 1,859 subjects were eligible. A random sample of 663 (mean age, 58.2 ± 10.8; mean BMI, 26.0 ± 4.6), except six with known OSA, were invited for polysomnography (PSG). Of 165 subjects on which PSG was performed, OSA was diagnosed (apnea-hypopnea index [AHI] ≥ 5.0/h) in 89 subjects (53.9%, median Epworth Sleepiness Scale, 6 [interquartile range 3, 10]). Fifty-four (32.7%) had moderate/severe OSA (AHI ≥ 15/h). The estimated OSA prevalence in this diabetic cohort was 17.5% (24.7% in men, 10.3% in women). Regression analysis identified that AHI was associated independently with higher BMI, advanced age, male sex, and higher diastolic BP (R(2) = 29.6%). The adjusted OR of requiring three or more antihypertensive drugs in moderate/severe OSA was 2.48 (95% CI, 1.05-5.87). No association between glycemic control (HbA1c) and sleep was identified.In conclusion, OSA is more prevalent in Chinese adults with DM than in the general population. A high index of suspicion for OSA in patients with DM is warranted, because they may not have overt daytime sleepiness. |
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| ISSN: | 00123692 |
| DOI: | 10.1378/chest.10-0596 |