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Temporal trends in incidence of childhood cancer in Switzerland, 1985-2014

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Titel: Temporal trends in incidence of childhood cancer in Switzerland, 1985-2014
Autoren: Sommer, Grit, Schindler, Matthias, Redmond, Shelagh, Pfeiffer, Verena, Konstantinoudis, Garyfallos, Ammann, Roland A, Ansari Djaberi, Marc Georges, Hengartner, Heinz, Michel, Gisela, Kuehni, Claudia E, Swiss Paediatric Oncology Group (SPOG)
Quelle: Cancer Epidemiology, Vol. 61 (2019) pp. 157-164
Publication Status: Preprint
Verlagsinformationen: Cold Spring Harbor Laboratory, 2019.
Publikationsjahr: 2019
Schlagwörter: Male, ddc:618, Adolescent, Incidence, Infant, Newborn, Infant, History, 20th Century, History, 21st Century, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Cancer Survivors, Risk Factors, Child, Preschool, Humans, Female, Child, Switzerland, Cancer Survivors/statistics & numerical data
Beschreibung: STRUCTURED ABSTRACTBackgroundIncidence of childhood cancer increased in most countries worldwide, but the reasons are unclear. This study investigates trends in childhood cancer incidence in Switzerland from 1985 to 2014.MethodsWe extracted data on all childhood cancer cases diagnosed at ages 0-14 years in Switzerland from the Swiss Childhood Cancer Registry. We included ICCC-3 main groups I-XII and calculated age-standardised, cumulative, and age-specific incidence for different diagnostic groups. We analysed trends in annual age-standardised incidence using JoinPoint regression models.ResultsOver the study period from 1985-2014, 5104 of 5486 cancer diagnoses (93%) were microscopically verified. The proportion of children treated in paediatric cancer centres increased from 84% during 1985-1994 to 93% in 1995-2004 and 98% in 2005-2014 (pConclusionTrends in incidence were driven mostly by increases among leukaemias and CNS tumours. For CNS tumours, observed trends may be explained at least partially by diagnostic changes and improved registration. For leukaemias, rising incidence may be real and at least partly due to changes in risk factors.HighlightsIn Switzerland, incidence of childhood cancer increased by 18% from 1985-2014.Increase in incidence was mainly caused by brain tumours and leukaemias.Improved registration and diagnostics may have increased brain tumour incidence.Increasing trend for leukaemias may be real, but reasons remain elusive.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf
ISSN: 1877-7821
DOI: 10.1101/670224
DOI: 10.1016/j.canep.2019.06.002
DOI: 10.7892/boris.132012
Zugangs-URL: https://boris.unibe.ch/132012/7/Sommer%20CancerEpidemiol%202019_preprint.pdf
https://pubmed.ncbi.nlm.nih.gov/31279990
https://www.sciencedirect.com/science/article/pii/S1877782118307124
https://pubmed.ncbi.nlm.nih.gov/31279990/
https://boris.unibe.ch/132012/
https://www.ncbi.nlm.nih.gov/pubmed/31279990
https://archive-ouverte.unige.ch/unige:145655
https://www.biorxiv.org/content/biorxiv/early/2019/06/14/670224.full.pdf
https://www.biorxiv.org/content/10.1101/670224v1
https://archive-ouverte.unige.ch/unige:145655
Rights: CC BY NC ND
Elsevier TDM
Dokumentencode: edsair.doi.dedup.....2ad86fed394d0c5631489891c9ba7cfa
Datenbank: OpenAIRE
Beschreibung
Abstract:STRUCTURED ABSTRACTBackgroundIncidence of childhood cancer increased in most countries worldwide, but the reasons are unclear. This study investigates trends in childhood cancer incidence in Switzerland from 1985 to 2014.MethodsWe extracted data on all childhood cancer cases diagnosed at ages 0-14 years in Switzerland from the Swiss Childhood Cancer Registry. We included ICCC-3 main groups I-XII and calculated age-standardised, cumulative, and age-specific incidence for different diagnostic groups. We analysed trends in annual age-standardised incidence using JoinPoint regression models.ResultsOver the study period from 1985-2014, 5104 of 5486 cancer diagnoses (93%) were microscopically verified. The proportion of children treated in paediatric cancer centres increased from 84% during 1985-1994 to 93% in 1995-2004 and 98% in 2005-2014 (pConclusionTrends in incidence were driven mostly by increases among leukaemias and CNS tumours. For CNS tumours, observed trends may be explained at least partially by diagnostic changes and improved registration. For leukaemias, rising incidence may be real and at least partly due to changes in risk factors.HighlightsIn Switzerland, incidence of childhood cancer increased by 18% from 1985-2014.Increase in incidence was mainly caused by brain tumours and leukaemias.Improved registration and diagnostics may have increased brain tumour incidence.Increasing trend for leukaemias may be real, but reasons remain elusive.
ISSN:18777821
DOI:10.1101/670224