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Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study

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Title: Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study
Authors: Rigoni, Isotta, Rué Queralt, J., Glomb, K., Preti, Maria Giulia, Roehri, Nicolas, Tourbier, S., Spinelli, Laurent, Seeck, Margitta, Van De Ville, Dimitri, Hagmann, P., Vulliemoz, Serge
Source: Clinical neurophysiology, vol. 153, pp. 1-10
Publisher Information: Elsevier BV, 2023.
Publication Year: 2023
Subject Terms: Humans, Epilepsy, Temporal Lobe, Electroencephalography, Temporal Lobe, Epilepsy, Brain, Magnetic Resonance Imaging, EEG, Graph signal processing, Structure–function coupling, Temporal lobe epilepsy, 616.8, 616.0757
Description: Structure-function coupling remains largely unknown in brain disorders. We studied this coupling during interictal epileptic discharges (IEDs), using graph signal processing in temporal lobe epilepsy (TLE).We decomposed IEDs of 17 patients on spatial maps, i.e. network harmonics, extracted from a structural connectome. Harmonics were split in smooth maps (long-range interactions reflecting integration) and coarse maps (short-range interactions reflecting segregation) and were used to reconstruct the part of the signal coupled (Xc) and decoupled (Xd) from the structure, respectively. We analysed how Xc and Xd embed the IED energy over time, at global and regional level.For Xc, the energy was smaller than for Xd before the IED onset (p < .001), but became larger around the first IED peak (p < .05, cluster 2, C2). Locally, the ipsilateral mesial regions were significantly coupled to the structure over the whole epoch. The ipsilateral hippocampus increased its coupling during C2 (p < .01).At whole-brain level, segregation gives way to integrative processes during the IED. Locally, brain regions commonly involved in the TLE epileptogenic network increase their reliance on long-range couplings during IED (C2).In TLE, integration mechanisms prevail during the IED and are localized in the ipsilateral mesial temporal regions.
Document Type: Article
File Description: application/pdf
Language: English
ISSN: 1388-2457
DOI: 10.1016/j.clinph.2023.05.012
Access URL: https://pubmed.ncbi.nlm.nih.gov/37364402
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D6CDF9A689358
https://serval.unil.ch/notice/serval:BIB_D6CDF9A68935
https://serval.unil.ch/resource/serval:BIB_D6CDF9A68935.P001/REF.pdf
Rights: CC BY
Accession Number: edsair.doi.dedup.....1f86ed93b441b6bfc4a19c7f4717e97c
Database: OpenAIRE
Description
Abstract:Structure-function coupling remains largely unknown in brain disorders. We studied this coupling during interictal epileptic discharges (IEDs), using graph signal processing in temporal lobe epilepsy (TLE).We decomposed IEDs of 17 patients on spatial maps, i.e. network harmonics, extracted from a structural connectome. Harmonics were split in smooth maps (long-range interactions reflecting integration) and coarse maps (short-range interactions reflecting segregation) and were used to reconstruct the part of the signal coupled (Xc) and decoupled (Xd) from the structure, respectively. We analysed how Xc and Xd embed the IED energy over time, at global and regional level.For Xc, the energy was smaller than for Xd before the IED onset (p < .001), but became larger around the first IED peak (p < .05, cluster 2, C2). Locally, the ipsilateral mesial regions were significantly coupled to the structure over the whole epoch. The ipsilateral hippocampus increased its coupling during C2 (p < .01).At whole-brain level, segregation gives way to integrative processes during the IED. Locally, brain regions commonly involved in the TLE epileptogenic network increase their reliance on long-range couplings during IED (C2).In TLE, integration mechanisms prevail during the IED and are localized in the ipsilateral mesial temporal regions.
ISSN:13882457
DOI:10.1016/j.clinph.2023.05.012