Optogenetics at the presynapse
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| Název: | Optogenetics at the presynapse |
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| Autoři: | Benjamin R. Rost, Jonas Wietek, Ofer Yizhar, Dietmar Schmitz |
| Zdroj: | Nature neuroscience 25(8), 984-998 (2022). doi:10.1038/s41593-022-01113-6 Nature Neuroscience |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2022. |
| Rok vydání: | 2022 |
| Témata: | Optogenetics, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Neuronal Plasticity, genetics [Opsins], Opsins, physiology [Synaptic Transmission], Presynaptic Terminals, ddc:610, Synaptic Transmission, 3. Good health |
| Popis: | Optogenetic actuators enable highly precise spatiotemporal interrogation of biological processes at levels ranging from the subcellular to cells, circuits and behaving organisms. Although their application in neuroscience has traditionally focused on the control of spiking activity at the somatodendritic level, the scope of optogenetic modulators for direct manipulation of presynaptic functions is growing. Presynaptically localized opsins combined with light stimulation at the terminals allow light-mediated neurotransmitter release, presynaptic inhibition, induction of synaptic plasticity and specific manipulation of individual components of the presynaptic machinery. Here, we describe presynaptic applications of optogenetic tools in the context of the unique cell biology of axonal terminals, discuss their potential shortcomings and outline future directions for this rapidly developing research area. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-022-01113-6 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/35835882 |
| Rights: | Springer TDM |
| Přístupové číslo: | edsair.doi.dedup.....1bfd67132c3710c57a1b97e009c809cd |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Optogenetic actuators enable highly precise spatiotemporal interrogation of biological processes at levels ranging from the subcellular to cells, circuits and behaving organisms. Although their application in neuroscience has traditionally focused on the control of spiking activity at the somatodendritic level, the scope of optogenetic modulators for direct manipulation of presynaptic functions is growing. Presynaptically localized opsins combined with light stimulation at the terminals allow light-mediated neurotransmitter release, presynaptic inhibition, induction of synaptic plasticity and specific manipulation of individual components of the presynaptic machinery. Here, we describe presynaptic applications of optogenetic tools in the context of the unique cell biology of axonal terminals, discuss their potential shortcomings and outline future directions for this rapidly developing research area. |
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| ISSN: | 15461726 10976256 |
| DOI: | 10.1038/s41593-022-01113-6 |