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Mechanisms of copper metabolism and cuproptosis: implications for liver diseases

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Název: Mechanisms of copper metabolism and cuproptosis: implications for liver diseases
Autoři: Haoran Chen, Dongxuan Li, Huimin Zhang, Meiqi Zhang, Yumeng Lin, Haibei He, Aijun Liu, Shiming Shen, Yi Wang, Zhongyu Han
Zdroj: Frontiers in Immunology, Vol 16 (2025)
Informace o vydavateli: Frontiers Media SA, 2025.
Rok vydání: 2025
Témata: cuproptosis, non-alcoholic fatty liver disease, copper metabolism, acute liver injury, Immunologic diseases. Allergy, RC581-607, Wilson disease, alcoholic liver disease
Popis: Copper is an essential trace element in the human body, involved in various biological processes, including cell metabolism, nerve development, and immune function. Its homeostasis is vital for maintaining normal cellular functions, and disruptions in copper homeostasis can lead to a wide range of diseases. Cuproptosis is a copper ion–dependent form of programmed cell death that leads to abnormal oligomerization of lipoylated proteins and dysfunction of iron-sulfur cluster proteins in the mitochondrial tricarboxylic acid (TCA) cycle, thereby triggering intracellular oxidative stress and proteotoxic stress. In this review, we have delved into the mechanisms of copper metabolism and cuproptosis, as well as their roles in several liver diseases, including Wilson disease (WD), alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), acute liver injury (ALI), and hepatocellular carcinoma (HCC), as well as their therapeutic potential.
Druh dokumentu: Article
ISSN: 1664-3224
DOI: 10.3389/fimmu.2025.1633711
Přístupová URL adresa: https://doaj.org/article/ee92120314a5460d85ad0de9a4f5eaac
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....182e308cae38e2d1b39f2c49285e18f7
Databáze: OpenAIRE
Popis
Abstrakt:Copper is an essential trace element in the human body, involved in various biological processes, including cell metabolism, nerve development, and immune function. Its homeostasis is vital for maintaining normal cellular functions, and disruptions in copper homeostasis can lead to a wide range of diseases. Cuproptosis is a copper ion–dependent form of programmed cell death that leads to abnormal oligomerization of lipoylated proteins and dysfunction of iron-sulfur cluster proteins in the mitochondrial tricarboxylic acid (TCA) cycle, thereby triggering intracellular oxidative stress and proteotoxic stress. In this review, we have delved into the mechanisms of copper metabolism and cuproptosis, as well as their roles in several liver diseases, including Wilson disease (WD), alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), acute liver injury (ALI), and hepatocellular carcinoma (HCC), as well as their therapeutic potential.
ISSN:16643224
DOI:10.3389/fimmu.2025.1633711