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The clinicopathological significance and prognostic impact of 14-3-3σ/stratifin expression on patients with surgically resectable intrahepatic cholangiocarcinoma

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Title: The clinicopathological significance and prognostic impact of 14-3-3σ/stratifin expression on patients with surgically resectable intrahepatic cholangiocarcinoma
Authors: Su-Hung Wang, Yao-Yu Hsieh, Khaa Hoo Ong, Hong-Yue Lai, Hsin-Hwa Tsai, Ding-Ping Sun, Steven Kuan-Hua Huang, Yu-Feng Tian, Hung-Chang Wu, Ti-Chun Chan, Keva Joseph, I-Wei Chang
Source: Asian Journal of Surgery, Vol 48, Iss 1, Pp 250-260 (2025)
Publisher Information: Elsevier BV, 2025.
Publication Year: 2025
Subject Terms: Stratifin, RD1-811, SFN, Surgery, 14-3-3σ, Prognosis, Cell proliferation, Intrahepatic cholangiocarcinoma
Description: Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer after hepatocellular carcinoma. Through data mining of publicly available iCCA transcriptomic datasets from the Gene Expression Omnibus, we identified SFN as the most significantly up-regulated gene in iCCA compared to normal tissue, focusing on the Gene Ontology term "cell proliferation" (GO:0008283). SFN encodes the 14-3-3σ protein, also known as stratifin, which plays crucial roles in various cellular processes.Immunohistochemistry was used to assess stratifin expression in 182 patients with localized iCCAs undergoing surgical resection. Patients were divided into low and high expression groups, and the association between stratifin expression and clinicopathological features was analyzed. Univariate and multivariate survival analyses were performed to assess overall survival (OS), disease-specific survival (DSS), local recurrence-free survival (LRFS), and metastasis-free survival (MeFS).Elevated stratifin expression in iCCAs was significantly associated with the absence of hepatitis, positive surgical margins, advanced primary tumor stages, and higher histological grades (all p ≤ 0.011). Survival analyses demonstrated a significant negative association between stratifin expression and all prognostic indicators, including OS, DSS, LRFS, and MeFS (all p ≤ 0.0004). Multivariate analysis revealed that stratifin overexpression was significantly correlated with poorer outcomes in terms of DSS, LRFS, and MeFS (all p
Document Type: Article
Language: English
ISSN: 1015-9584
DOI: 10.1016/j.asjsur.2024.08.133
Access URL: https://pubmed.ncbi.nlm.nih.gov/39232956
https://doaj.org/article/bbec951f1a0947aa80af30a94f3fa3d1
Rights: CC BY NC ND
Accession Number: edsair.doi.dedup.....15b9b99e48f50eb2d8a01f4d3aa7ca5c
Database: OpenAIRE
Description
Abstract:Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer after hepatocellular carcinoma. Through data mining of publicly available iCCA transcriptomic datasets from the Gene Expression Omnibus, we identified SFN as the most significantly up-regulated gene in iCCA compared to normal tissue, focusing on the Gene Ontology term "cell proliferation" (GO:0008283). SFN encodes the 14-3-3σ protein, also known as stratifin, which plays crucial roles in various cellular processes.Immunohistochemistry was used to assess stratifin expression in 182 patients with localized iCCAs undergoing surgical resection. Patients were divided into low and high expression groups, and the association between stratifin expression and clinicopathological features was analyzed. Univariate and multivariate survival analyses were performed to assess overall survival (OS), disease-specific survival (DSS), local recurrence-free survival (LRFS), and metastasis-free survival (MeFS).Elevated stratifin expression in iCCAs was significantly associated with the absence of hepatitis, positive surgical margins, advanced primary tumor stages, and higher histological grades (all p ≤ 0.011). Survival analyses demonstrated a significant negative association between stratifin expression and all prognostic indicators, including OS, DSS, LRFS, and MeFS (all p ≤ 0.0004). Multivariate analysis revealed that stratifin overexpression was significantly correlated with poorer outcomes in terms of DSS, LRFS, and MeFS (all p
ISSN:10159584
DOI:10.1016/j.asjsur.2024.08.133