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Comparative Evaluation of Post-Operative Cognitive Function in Patients Undergoing Septoplasty Using Controlled Hypotensive and Normotensive Anaesthesia

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Název: Comparative Evaluation of Post-Operative Cognitive Function in Patients Undergoing Septoplasty Using Controlled Hypotensive and Normotensive Anaesthesia
Autoři: Manyata Nema, Neha Mehra, Gurpreet Kaur Atwal, Tenzin Kyizom, Robina Makkar
Informace o vydavateli: International Journal of Pharmaceutical and Clinical Research, 2023.
Rok vydání: 2023
Témata: Hypotensive Anaesthesia, Septoplasty, Mini Mental State, Cognitive Function, 3. Good health
Popis: Background: The phenomenon of postoperative cognitive dysfunction (POCD) after anesthesia and surgery is a recognized clinical concern that is characterized by a decline in cognitive performance. Controlled hypotension during anesthesia is a technique used to reduce blood loss in certain surgeries, such as septoplasty, and has been found to be effective in drying the surgical field, shortening the duration of surgery, and improving surgical access. However, the effect of controlled hypotension on postoperative cognitive function remains unknown. This prospective randomized study aims to compare the postoperative cognitive function of patients undergoing septoplasty using controlled hypotensive and normotensive anesthesiausing the Mini-Mental State Examination (MMSE) score. Methods: The present prospective, randomised, comparative study was conducted among 60 patients undergoing elective septoplasty under Department of Anaesthesiology and Critical Care. The study was approved by Institution Ethics Committee. All patients underwent prea anesthetic evaluation on the day prior to surgery. A total of 60 patients scheduled for septoplasty under general anaesthesia at SMIH, Patel Nagar, Dehradun, over a period of 18 months were recruited for the study. They were divided into two groups by using computer generated randomization code. Group A : (n =30) – Controlled hypotensive anesthesia using isoflurane, Group B : (n =30) – Normotensive anaesthesia using local anaesthetic agent and vasoconstrictor. Data were coded and recorded in MS Excel spreadsheet program. All statistical calculations were done using (Statistical Package for the Social Science)SPSS 21version (SPSS Inc., Chicago, IL, USA )statistical program for Microsoft Windows. Results: In our study, MMSE score at 30 minutes post-operative period, was lower in Group A [24.6 ± 0.6] than Group B [27.7 ± 0.7 ] and it was statistically significant [ p < 0.05]. Conclusion: Our results showed that patients in the controlled hypotension group experienced a statistically significant drop in MMSE score at 30 minutes postoperatively, while patients in the normotensive group did not experience a significant decline in cognitive function. These findings are consistent with previous studies that have reported a higher incidence of POCD in patients undergoing controlled hypotension.
Druh dokumentu: Article
Jazyk: English
DOI: 10.5281/zenodo.12511125
DOI: 10.5281/zenodo.12511124
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....0ce95e314bb541b34562d17f577f0b9c
Databáze: OpenAIRE
Popis
Abstrakt:Background: The phenomenon of postoperative cognitive dysfunction (POCD) after anesthesia and surgery is a recognized clinical concern that is characterized by a decline in cognitive performance. Controlled hypotension during anesthesia is a technique used to reduce blood loss in certain surgeries, such as septoplasty, and has been found to be effective in drying the surgical field, shortening the duration of surgery, and improving surgical access. However, the effect of controlled hypotension on postoperative cognitive function remains unknown. This prospective randomized study aims to compare the postoperative cognitive function of patients undergoing septoplasty using controlled hypotensive and normotensive anesthesiausing the Mini-Mental State Examination (MMSE) score. Methods: The present prospective, randomised, comparative study was conducted among 60 patients undergoing elective septoplasty under Department of Anaesthesiology and Critical Care. The study was approved by Institution Ethics Committee. All patients underwent prea anesthetic evaluation on the day prior to surgery. A total of 60 patients scheduled for septoplasty under general anaesthesia at SMIH, Patel Nagar, Dehradun, over a period of 18 months were recruited for the study. They were divided into two groups by using computer generated randomization code. Group A : (n =30) – Controlled hypotensive anesthesia using isoflurane, Group B : (n =30) – Normotensive anaesthesia using local anaesthetic agent and vasoconstrictor. Data were coded and recorded in MS Excel spreadsheet program. All statistical calculations were done using (Statistical Package for the Social Science)SPSS 21version (SPSS Inc., Chicago, IL, USA )statistical program for Microsoft Windows. Results: In our study, MMSE score at 30 minutes post-operative period, was lower in Group A [24.6 ± 0.6] than Group B [27.7 ± 0.7 ] and it was statistically significant [ p < 0.05]. Conclusion: Our results showed that patients in the controlled hypotension group experienced a statistically significant drop in MMSE score at 30 minutes postoperatively, while patients in the normotensive group did not experience a significant decline in cognitive function. These findings are consistent with previous studies that have reported a higher incidence of POCD in patients undergoing controlled hypotension.
DOI:10.5281/zenodo.12511125