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A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials

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Titel:	A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials
Autoren:	Jean-Didier Lemaréchal, Maciej Jedynak, Lena Trebaul, Anthony Boyer, François Tadel, Manik Bhattacharjee, Pierre Deman, Viateur Tuyisenge, Leila Ayoubian, Etienne Hugues, Blandine Chanteloup-Forêt, Carole Saubat, Raouf Zouglech, Gina Catalina Reyes Mejia, Sébastien Tourbier, Patric Hagmann, Claude Adam, Carmen Barba, Fabrice Bartolomei, Thomas Blauwblomme, Jonathan Curot, François Dubeau, Stefano Francione, Mercedes Garcés, Edouard Hirsch, Elizabeth Landré, Sinclair Liu, Louis Maillard, Eeva-Liisa Metsähonkala, Ioana Mindruta, Anca Nica, Martin Pail, Ana Maria Petrescu, Sylvain Rheims, Rodrigo Rocamora, Andreas Schulze-Bonhage, William Szurhaj, Delphine Taussig, Antonio Valentin, Haixiang Wang, Philippe Kahane, Nathalie George, Olivier David, Vincent Navarro, Arnaud Biraben, Dominique Menard, Milan Brazdil, Robert Kuba, Jitka Kočvarová, Irena Doležalová, Jean Gotman, Philippe Ryvlin, Jean Isnard, Hélène Catenoix, Alexandra Montavont, Agnès Trébuchon, Aileen McGonigal, Wenjing Zhou, Zhang Wei, Zhu Dan, Guo Qiang, Hu Xiangshu, Li Hua, Hua Gang, Wang Wensheng, Mei Xi, Feng Yigang, Rima Nabbout, Marie Bourgeois, Anna Kaminska, Rinki Singh, Liisa Metsähonkala, Eija Gaily, Leena Lauronen, Maria Peltola, Francine Chassoux, Philippe Derambure, Maxime Chochois, Maria Paola Valenti, Julia Scholly, Luc Valton, Marie Denuelle, Alessandro Principe, Miguel Ley, Andrei Barborica, Roberto Mai, Lino Nobili, Ivana Sartori, Laura Tassi, Jean-Pierre Vignal, Jacques Jonas, Louise Tyvaert, Mathilde Chipaux, Lorella Minotti, Anne-Sophie Job, Véronique Michel, Marie de Montaudoin, Jérôme Aupy, Viviane Bouilleret, Pascal Masnou, Claire Dussaule, Marion Quirins, Renzo Guerrini, Matteo Lenge, Elisa Nacci
Weitere Verfasser:	Sorbonne Université, Gestionnaire HAL 4, F-TRACT consortium, Adam, C., Navarro, V., Biraben, A., Nica, A., Menard, D., Brazdil, M., Kuba, R., Kočvarová, J., Pail, M., Doležalová, I., Dubeau, F., Gotman, J., Ryvlin, P., Isnard, J., Catenoix, H., Montavont, A., Rheims, S., Bartolomei, F., Trébuchon, A., McGonigal, A., Zhou, W., Wang, H., Liu, S., Wei, Z., Dan, Z., Qiang, G., Xiangshu, H., Hua, L., Gang, H., Wensheng, W., Xi, M., Yigang, F., Nabbout, R., Bourgeois, M., Kaminska, A., Blauwblomme, T., Garcés, M., Valentin, A., Singh, R., Metsähonkala, L., Gaily, E., Lauronen, L., Peltola, M., Chassoux, F., Landré, E., Derambure, P., Szurhaj, W., Chochois, M., Hirsch, E., Paola Valenti, M., Scholly, J., Valton, L., Denuelle, M., Curot, J., Rocamora, R., Principe, A., Ley, M., Mindruta, I., Barborica, A., Francione, S., Mai, R., Nobili, L., Sartori, I., Tassi, L., Maillard, L., Vignal, J.P., Jonas, J., Tyvaert, L., Chipaux, M., Taussig, D., Kahane, P., Minotti, L., Job, A.S., Michel, V., de Montaudoin, M., Aupy, J., Bouilleret, V., Maria Petrescu, A., Masnou, P., Dussaule, C., Quirins, M., Barba, C., Guerrini, R., Lenge, M., Nacci, E., Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), GIN Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital Lausanne (CHUV), Università degli Studi di Firenze = University of Florence = Université de Florence (UniFI), Service de neurochirurgie pédiatrique CHU Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche cerveau et cognition (CERCO UMR5549), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Montreal Neurological Institute and Hospital, McGill University = Université McGill Montréal, Canada, Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Centre Hospitalier Sainte Anne Paris, Jinan University Guangzhou, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Spitalul Universitar de Urgență București = University Emergency Hospital Bucharest, Romania (SUUB), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique Rennes (CIC), Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou, University Hospital Brno, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IMIM-Hospital del Mar, Generalitat de Catalunya = Generalidad de Cataluña = Government of Catalonia = Généralité de Catalogne, Universitäts Klinikum Freiburg = University Medical Center Freiburg (Uniklinik), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Tsinghua University Beijing (THU), The research leading to these results has received funding from the European Research Councilunder the European Union's Seventh Framework Programme (FP/2007-2013)/ERC GrantAgreement no. 616268 F-TRACT, the European Union’s Horizon 2020 FrameworkProgramme for Research and Innovation under Specific Grant Agreement No. 785907 and945539 (Human Brain Project SGA2 and SGA3), and from the French 'Investissementsd’avenir' programme under grant numbers ANR-11-INBS-0006 and ANR-10-IAHU-06. PHwas supported by Swiss National Science Foundation grant #CRSII5_170873, ANR-11-INBS-0006,FLI,France Life Imaging(2011), ANR-10-IAHU-0006,IHU-A-ICM,Institut de Neurosciences Translationnelles de Paris(2010), European Project: 616268,EC:FP7:ERC,ERC-2013-CoG,F-TRACT(2014), European Project: 785907,H2020,HBP SGA2(2018), European Project: 945539,H2020,H2020-SGA-FETFLAG-HBP-2019,HBP SGA3(2020), Pôle Neurosciences CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE), Université de Picardie Jules Verne (UPJV)
Quelle:	Brain Brain : a journal of neurology r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe Instituto de Investigación Sanitaria La Fe (IIS La Fe) BRAIN instname Brain, vol. 145, no. 5, pp. 1653-1667
Verlagsinformationen:	Oxford University Press (OUP), 2021.
Publikationsjahr:	2021
Schlagwörter:	neural mass models, Synaptic time constant, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, 03 medical and health sciences, axonal conduction delay, 0302 clinical medicine, Bayes Theorem, Brain, Brain Mapping/methods, Electric Stimulation/methods, Epilepsy, Evoked Potentials/physiology, Humans, cortico-cortical evoked potential, dynamic causal modelling, synaptic time constant, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neural mass models, Evoked Potentials, Cortico-cortical evoked potential, brain atlas , SEEG, Axonal conduction delay, Brain Mapping, Electric Stimulation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Original Article, Dynamic causal modelling
Beschreibung:	Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter connectivity. Cortico-cortical evoked potentials provide a unique window on functional brain networks because they contain sufficient information to infer dynamical properties of large-scale brain connectivity, such as preferred directionality and propagation latencies. Here, we developed a biologically informed modelling approach to estimate the neural physiological parameters of brain functional networks from the cortico-cortical evoked potentials recorded in a large multicentric database. Specifically, we considered each cortico-cortical evoked potential as the output of a transient stimulus entering the stimulated region, which directly propagated to the recording region. Both regions were modelled as coupled neural mass models, the parameters of which were estimated from the first cortico-cortical evoked potential component, occurring before 80 ms, using dynamic causal modelling and Bayesian model inversion. This methodology was applied to the data of 780 patients with epilepsy from the F-TRACT database, providing a total of 34 354 bipolar stimulations and 774 445 cortico-cortical evoked potentials. The cortical mapping of the local excitatory and inhibitory synaptic time constants and of the axonal conduction delays between cortical regions was obtained at the population level using anatomy-based averaging procedures, based on the Lausanne2008 and the HCP-MMP1 parcellation schemes, containing 130 and 360 parcels, respectively. To rule out brain maturation effects, a separate analysis was performed for older (>15 years) and younger patients ( To our knowledge, this study is the first to provide a local estimation of axonal conduction delays and synaptic time constants across the whole human cortex in vivo, based on intracerebral electrophysiological recordings.
Publikationsart:	Article Other literature type
Dateibeschreibung:	application/pdf; pdf
Sprache:	English
ISSN:	1460-2156 0006-8950
DOI:	10.1093/brain/awab362
Zugangs-URL:	https://hal.sorbonne-universite.fr/hal-03457509/file/awab362.pdf https://pubmed.ncbi.nlm.nih.gov/35416942 https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=16567 https://hal.sorbonne-universite.fr/hal-03457509v1 https://doi.org/10.1093/brain/awab362 https://hal.sorbonne-universite.fr/hal-03457509v1/document https://serval.unil.ch/notice/serval:BIB_D8584AD5A427 https://serval.unil.ch/resource/serval:BIB_D8584AD5A427.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D8584AD5A4270
Rights:	CC BY NC URL: http://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Dokumentencode:	edsair.doi.dedup.....0b6ecf5a5f76c482faf35ba94e79416d
Datenbank:	OpenAIRE

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Beschreibung
Abstract:	Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter connectivity. Cortico-cortical evoked potentials provide a unique window on functional brain networks because they contain sufficient information to infer dynamical properties of large-scale brain connectivity, such as preferred directionality and propagation latencies. Here, we developed a biologically informed modelling approach to estimate the neural physiological parameters of brain functional networks from the cortico-cortical evoked potentials recorded in a large multicentric database. Specifically, we considered each cortico-cortical evoked potential as the output of a transient stimulus entering the stimulated region, which directly propagated to the recording region. Both regions were modelled as coupled neural mass models, the parameters of which were estimated from the first cortico-cortical evoked potential component, occurring before 80 ms, using dynamic causal modelling and Bayesian model inversion. This methodology was applied to the data of 780 patients with epilepsy from the F-TRACT database, providing a total of 34 354 bipolar stimulations and 774 445 cortico-cortical evoked potentials. The cortical mapping of the local excitatory and inhibitory synaptic time constants and of the axonal conduction delays between cortical regions was obtained at the population level using anatomy-based averaging procedures, based on the Lausanne2008 and the HCP-MMP1 parcellation schemes, containing 130 and 360 parcels, respectively. To rule out brain maturation effects, a separate analysis was performed for older (>15 years) and younger patients ( To our knowledge, this study is the first to provide a local estimation of axonal conduction delays and synaptic time constants across the whole human cortex in vivo, based on intracerebral electrophysiological recordings.
ISSN:	14602156 00068950
DOI:	10.1093/brain/awab362