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Clinical manifestations of COVID‐19: An overview of 102 systematic reviews with evidence mapping

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Název: Clinical manifestations of COVID‐19: An overview of 102 systematic reviews with evidence mapping
Autoři: Luo, Xufei, Lv, Meng, Zhang, Xianzhuo, Estill, Janne Anton Markus, Yang, Bo, Lei, Ruobing, Ren, Mengjuan, Liu, Yunlan, Wang, Ling, Liu, Xiao, Wang, Qi, Meng, Min, Chen, Yaolong, COVID-19 evidence and recommendations working group
Zdroj: Journal of Evidence-Based Medicine. 15:201-215
Informace o vydavateli: Wiley, 2022.
Rok vydání: 2022
Témata: Adolescent, SARS-CoV-2, Infant, Newborn, COVID-19, Myalgia, 3. Good health, Evidence map, Clinical manifestations, Cough / etiology, Fatigue / etiology, 03 medical and health sciences, 0302 clinical medicine, Cough, Pregnancy, Myalgia / etiology, Systematic review, Humans, Female, Child, Fatigue
Popis: ObjectiveCoronavirus disease 2019 (COVID‐19) has rapidly spread worldwide, but there is so far no comprehensive analysis of all known symptoms of the disease. Our study aimed to present a comprehensive picture of the clinical symptoms of COVID‐19 using an evidence map.MethodsWe systematically searched MEDLINE via PubMed, Web of Science, Embase, and Cochrane library from their inception to March 16, 2021. We included systematic reviews reporting the clinical manifestations of COVID‐19 patients. We followed the PRISMA guidelines, and the study selection, data extraction, and quality assessment were done by two individuals independently. We assessed the methodological quality of the studies using AMSTAR. We visually presented the clinical symptoms of COVID‐19 and their prevalence.ResultsA total of 102 systematic reviews were included, of which, 68 studies (66.7%) were of high quality, 19 studies (18.6%) of medium quality, and 15 studies (14.7%) of low quality. We identified a total of 74 symptoms including 17 symptoms of the respiratory system, 21 symptoms of the neurological system, 10 symptoms of the gastrointestinal system, 16 cutaneous symptoms, and 10 ocular symptoms. The most common symptoms were fever (67 studies, ranging 16.3%–91.0%, pooled prevalence: 64.6%, 95%CI, 61.3%–67.9%), cough (68 studies, ranging 30.0%–72.2%, pooled prevalence: 53.6%, 95%CI, 52.1%–55.1%), muscle soreness (56 studies, ranging 3.0%–44.0%, pooled prevalence: 18.7%, 95%CI, 16.3%–21.3%), and fatigue (52 studies, ranging 3.3%‐58.5%, pooled prevalence: 29.4%, 95%CI, 27.5%–31.3%). The prevalence estimates for COVID‐19 symptoms were generally lower in neonates, children and adolescents, and pregnant women than in the general populations.ConclusionAt least 74 different clinical manifestations are associated with COVID‐19. Fever, cough, muscle soreness, and fatigue are the most common, but attention should also be paid to the rare symptoms that can help in the early diagnosis of the disease.
Druh dokumentu: Article
Popis souboru: application/pdf
Jazyk: English
ISSN: 1756-5391
1756-5383
DOI: 10.1111/jebm.12483
DOI: 10.48350/171688
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/35909298
Rights: Wiley Online Library User Agreement
Přístupové číslo: edsair.doi.dedup.....02d110a997ba4ac8f1d97a39275890ea
Databáze: OpenAIRE
Popis
Abstrakt:ObjectiveCoronavirus disease 2019 (COVID‐19) has rapidly spread worldwide, but there is so far no comprehensive analysis of all known symptoms of the disease. Our study aimed to present a comprehensive picture of the clinical symptoms of COVID‐19 using an evidence map.MethodsWe systematically searched MEDLINE via PubMed, Web of Science, Embase, and Cochrane library from their inception to March 16, 2021. We included systematic reviews reporting the clinical manifestations of COVID‐19 patients. We followed the PRISMA guidelines, and the study selection, data extraction, and quality assessment were done by two individuals independently. We assessed the methodological quality of the studies using AMSTAR. We visually presented the clinical symptoms of COVID‐19 and their prevalence.ResultsA total of 102 systematic reviews were included, of which, 68 studies (66.7%) were of high quality, 19 studies (18.6%) of medium quality, and 15 studies (14.7%) of low quality. We identified a total of 74 symptoms including 17 symptoms of the respiratory system, 21 symptoms of the neurological system, 10 symptoms of the gastrointestinal system, 16 cutaneous symptoms, and 10 ocular symptoms. The most common symptoms were fever (67 studies, ranging 16.3%–91.0%, pooled prevalence: 64.6%, 95%CI, 61.3%–67.9%), cough (68 studies, ranging 30.0%–72.2%, pooled prevalence: 53.6%, 95%CI, 52.1%–55.1%), muscle soreness (56 studies, ranging 3.0%–44.0%, pooled prevalence: 18.7%, 95%CI, 16.3%–21.3%), and fatigue (52 studies, ranging 3.3%‐58.5%, pooled prevalence: 29.4%, 95%CI, 27.5%–31.3%). The prevalence estimates for COVID‐19 symptoms were generally lower in neonates, children and adolescents, and pregnant women than in the general populations.ConclusionAt least 74 different clinical manifestations are associated with COVID‐19. Fever, cough, muscle soreness, and fatigue are the most common, but attention should also be paid to the rare symptoms that can help in the early diagnosis of the disease.
ISSN:17565391
17565383
DOI:10.1111/jebm.12483