Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes
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| Title: | Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes |
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| Authors: | Prídavková Zuzana, Alena Furdová, Plank Lukáš, Žiak Peter, Halička Juraj, Benca-Kapitánová Karolína, Vida Rastislav, Bartoš Vladimír |
| Source: | Medical Research Archives. |
| Publisher Information: | Knowledge Enterprise Journals, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | 3. Good health |
| Description: | Background The purpose of this paper was to evaluate the association of the Bcl-2 protein, Ki-67 antigen expression and the apoptotic index with biological behaviour of basal cell carcinoma. Methods Combined analysis of retrospective and prospective study of data from two centres over a period of years 2008–2023 on histologically confirmed basal cell carcinoma without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated. Results The study cohort included 66 patients with 68 basal cell carcinomas of the eyelids (n = 68). The median age was 68 years. Resection margins < 2 mm were in 33.9 %, without any connection to recurrence rate (p = 0.076). Average value of Bcl-2 expression in non-aggressive types was 82.65 % (p = 0.000). The value of Ki-67 expression in patients with non-aggressive tumours amounted to 35.49 % (p = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535). No Grade III case was observed in the aggressive types. In two cases, the orbital exenteration was carried out (0.03 %). In one case was administered biological therapy. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 cases (0.06 %). Conclusion New information on cancer biomarkers in basal cell carcinoma contribute to choosing a correct therapy with achieving good aesthetic results and a good survival rate. Key words: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology Keywords: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology |
| Document Type: | Article |
| ISSN: | 2375-1924 2375-1916 |
| DOI: | 10.18103/mra.v12i7.5598 |
| Accession Number: | edsair.doi...........f64f23f5a3dae4fe58876be1fa3e40ee |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Background The purpose of this paper was to evaluate the association of the Bcl-2 protein, Ki-67 antigen expression and the apoptotic index with biological behaviour of basal cell carcinoma. Methods Combined analysis of retrospective and prospective study of data from two centres over a period of years 2008–2023 on histologically confirmed basal cell carcinoma without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated. Results The study cohort included 66 patients with 68 basal cell carcinomas of the eyelids (n = 68). The median age was 68 years. Resection margins < 2 mm were in 33.9 %, without any connection to recurrence rate (p = 0.076). Average value of Bcl-2 expression in non-aggressive types was 82.65 % (p = 0.000). The value of Ki-67 expression in patients with non-aggressive tumours amounted to 35.49 % (p = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535). No Grade III case was observed in the aggressive types. In two cases, the orbital exenteration was carried out (0.03 %). In one case was administered biological therapy. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 cases (0.06 %). Conclusion New information on cancer biomarkers in basal cell carcinoma contribute to choosing a correct therapy with achieving good aesthetic results and a good survival rate. Key words: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology Keywords: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology |
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| ISSN: | 23751924 23751916 |
| DOI: | 10.18103/mra.v12i7.5598 |