Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes
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| Název: | Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes |
|---|---|
| Autoři: | Prídavková Zuzana, Alena Furdová, Plank Lukáš, Žiak Peter, Halička Juraj, Benca-Kapitánová Karolína, Vida Rastislav, Bartoš Vladimír |
| Zdroj: | Medical Research Archives. |
| Informace o vydavateli: | Knowledge Enterprise Journals, 2024. |
| Rok vydání: | 2024 |
| Témata: | 3. Good health |
| Popis: | Background The purpose of this paper was to evaluate the association of the Bcl-2 protein, Ki-67 antigen expression and the apoptotic index with biological behaviour of basal cell carcinoma. Methods Combined analysis of retrospective and prospective study of data from two centres over a period of years 2008–2023 on histologically confirmed basal cell carcinoma without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated. Results The study cohort included 66 patients with 68 basal cell carcinomas of the eyelids (n = 68). The median age was 68 years. Resection margins < 2 mm were in 33.9 %, without any connection to recurrence rate (p = 0.076). Average value of Bcl-2 expression in non-aggressive types was 82.65 % (p = 0.000). The value of Ki-67 expression in patients with non-aggressive tumours amounted to 35.49 % (p = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535). No Grade III case was observed in the aggressive types. In two cases, the orbital exenteration was carried out (0.03 %). In one case was administered biological therapy. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 cases (0.06 %). Conclusion New information on cancer biomarkers in basal cell carcinoma contribute to choosing a correct therapy with achieving good aesthetic results and a good survival rate. Key words: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology Keywords: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology |
| Druh dokumentu: | Article |
| ISSN: | 2375-1924 2375-1916 |
| DOI: | 10.18103/mra.v12i7.5598 |
| Přístupové číslo: | edsair.doi...........f64f23f5a3dae4fe58876be1fa3e40ee |
| Databáze: | OpenAIRE |
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| Header | DbId: edsair DbLabel: OpenAIRE An: edsair.doi...........f64f23f5a3dae4fe58876be1fa3e40ee RelevancyScore: 914 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 914.415405273438 |
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| Items | – Name: Title Label: Title Group: Ti Data: Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Prídavková+Zuzana%22">Prídavková Zuzana</searchLink><br /><searchLink fieldCode="AR" term="%22Alena+Furdová%22">Alena Furdová</searchLink><br /><searchLink fieldCode="AR" term="%22Plank+Lukáš%22">Plank Lukáš</searchLink><br /><searchLink fieldCode="AR" term="%22Žiak+Peter%22">Žiak Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Halička+Juraj%22">Halička Juraj</searchLink><br /><searchLink fieldCode="AR" term="%22Benca-Kapitánová+Karolína%22">Benca-Kapitánová Karolína</searchLink><br /><searchLink fieldCode="AR" term="%22Vida+Rastislav%22">Vida Rastislav</searchLink><br /><searchLink fieldCode="AR" term="%22Bartoš+Vladimír%22">Bartoš Vladimír</searchLink> – Name: TitleSource Label: Source Group: Src Data: <i>Medical Research Archives</i>. – Name: Publisher Label: Publisher Information Group: PubInfo Data: Knowledge Enterprise Journals, 2024. – Name: DatePubCY Label: Publication Year Group: Date Data: 2024 – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%223%2E+Good+health%22">3. Good health</searchLink> – Name: Abstract Label: Description Group: Ab Data: Background The purpose of this paper was to evaluate the association of the Bcl-2 protein, Ki-67 antigen expression and the apoptotic index with biological behaviour of basal cell carcinoma. Methods Combined analysis of retrospective and prospective study of data from two centres over a period of years 2008–2023 on histologically confirmed basal cell carcinoma without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated. Results The study cohort included 66 patients with 68 basal cell carcinomas of the eyelids (n = 68). The median age was 68 years. Resection margins < 2 mm were in 33.9 %, without any connection to recurrence rate (p = 0.076). Average value of Bcl-2 expression in non-aggressive types was 82.65 % (p = 0.000). The value of Ki-67 expression in patients with non-aggressive tumours amounted to 35.49 % (p = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535). No Grade III case was observed in the aggressive types. In two cases, the orbital exenteration was carried out (0.03 %). In one case was administered biological therapy. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 cases (0.06 %). Conclusion New information on cancer biomarkers in basal cell carcinoma contribute to choosing a correct therapy with achieving good aesthetic results and a good survival rate. Key words: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology Keywords: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology – Name: TypeDocument Label: Document Type Group: TypDoc Data: Article – Name: ISSN Label: ISSN Group: ISSN Data: 2375-1924<br />2375-1916 – Name: DOI Label: DOI Group: ID Data: 10.18103/mra.v12i7.5598 – Name: AN Label: Accession Number Group: ID Data: edsair.doi...........f64f23f5a3dae4fe58876be1fa3e40ee |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.18103/mra.v12i7.5598 Languages: – Text: Undetermined Subjects: – SubjectFull: 3. Good health Type: general Titles: – TitleFull: Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Prídavková Zuzana – PersonEntity: Name: NameFull: Alena Furdová – PersonEntity: Name: NameFull: Plank Lukáš – PersonEntity: Name: NameFull: Žiak Peter – PersonEntity: Name: NameFull: Halička Juraj – PersonEntity: Name: NameFull: Benca-Kapitánová Karolína – PersonEntity: Name: NameFull: Vida Rastislav – PersonEntity: Name: NameFull: Bartoš Vladimír IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 23751924 – Type: issn-print Value: 23751916 – Type: issn-locals Value: edsair Titles: – TitleFull: Medical Research Archives Type: main |
| ResultId | 1 |