A correction for modeling of radial, spiral, and PROPELLOR DCE data: time-averaged extended Tofts
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| Title: | A correction for modeling of radial, spiral, and PROPELLOR DCE data: time-averaged extended Tofts |
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| Authors: | Natalia Korobova, Marian Troelstra, Oliver Gurney-Champion |
| Source: | ISMRM Annual Meeting. |
| Publisher Information: | ISMRM, 2024. |
| Publication Year: | 2024 |
| Description: | Motivation: Accurate quantification of pharmacokinetic parameters in dynamic contrast-enhanced (DCE) MRI requires high temporal resolution, often reached through non-cartesian sampling patterns that oversample the center of k-space (e.g. radial, spiral, PROPELLOR). In pharmacokinetic models, image contrast is assumed to be formed instantly at discrete time-points. However, in acquisitions oversampling the k-space center, the signal per time-frame becomes an average over acquisition time. Goal(s): To correct for the time-averaged signals. Approach: We proposed a modification to DCE modeling and tested it in simulations and in-vivo. Results: Modern sampling patterns predominantly affect the pharmacokinetic parameter estimates for longer sampling times (>8s) per DCE frame. Impact: We verified that for short acquisitions per frame (8s) per DCE frame, our time-averaged extended Toft's model is needed for accurate estimations of pharmacokinetic parameters. |
| Document Type: | Article |
| ISSN: | 1545-4428 |
| DOI: | 10.58530/2024/1045 |
| Accession Number: | edsair.doi...........9a9bb86aade3eb281109b7075ecf26ca |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Motivation: Accurate quantification of pharmacokinetic parameters in dynamic contrast-enhanced (DCE) MRI requires high temporal resolution, often reached through non-cartesian sampling patterns that oversample the center of k-space (e.g. radial, spiral, PROPELLOR). In pharmacokinetic models, image contrast is assumed to be formed instantly at discrete time-points. However, in acquisitions oversampling the k-space center, the signal per time-frame becomes an average over acquisition time. Goal(s): To correct for the time-averaged signals. Approach: We proposed a modification to DCE modeling and tested it in simulations and in-vivo. Results: Modern sampling patterns predominantly affect the pharmacokinetic parameter estimates for longer sampling times (>8s) per DCE frame. Impact: We verified that for short acquisitions per frame (8s) per DCE frame, our time-averaged extended Toft's model is needed for accurate estimations of pharmacokinetic parameters. |
|---|---|
| ISSN: | 15454428 |
| DOI: | 10.58530/2024/1045 |