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ИЗУЧЕНИЕ ЭКДИСТЕРОИДОВ ТРАВЫ СЕРПУХИ ВЕНЦЕНОСНОЙ (SERRATULA CORONATA L.): THE INVESTIGATION OF ECDISTEROIDS FROM SERRATULA CORONATA L.

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Název: ИЗУЧЕНИЕ ЭКДИСТЕРОИДОВ ТРАВЫ СЕРПУХИ ВЕНЦЕНОСНОЙ (SERRATULA CORONATA L.): THE INVESTIGATION OF ECDISTEROIDS FROM SERRATULA CORONATA L.
Zdroj: Вопросы обеспечения качества лекарственных средств. :34-42
Informace o vydavateli: Regional Public Organization of the Disabled "Human Health", 2020.
Rok vydání: 2020
Témata: α-экдизон, 20-гидроксиэкдизон, ayugasterone C, таксистерон, α-ecdysone, 22-пропиледен 20-гидроксиэкдизона, Serratula coronate L, taxisterone, аюгастерона С, фитоэкдистероиды, phytoecdysteroids, серпуха венценосная, 20-hydroxyecdysone, ЯМР-спектроскопия
Popis: Серпуха венценосная – растение-продуцент экдистероидов, представляющее интерес для внедрения в фармацевтическую практику и разработки лекарственных средств адаптогенного действия. В результате хроматографического разделения из надземной части серпухи венценосной (Serratula coronata L.), интродуцированной в Ботаническом саду ВИЛАР, было выделено пять основных экдистероидов, идентифицированных на основании данных ЯМР-спектроскопии. Подтверждено присутствие в серпухе венценосной четырех ранее идентифицированных соединений: 20-гидроксиэкдизона (1), аюгастерона С (2), α-экдизона (3) и таксистерона (4). Впервые выделено новое соединение - 20,22-пропиледен 20-гидроксиэкдизона (5). Ecdysteroids are triterpene compounds with four condensed rings having 27 or 28-29 carbon atoms. Ecdysteroids are widespread in the flora and fauna and have a wide spectrum of pharmacological activity. Low toxicity and high biological activity are the main indicators of the prospects for the use of drugs based on phytoecdysteroids. Serratula coronata L. - Asteraceae, containing a significant amount of ecditseroids, is an object of particular interest. The purpose of this investigation was to isolate and identify the main (dominant) phytoecdysteroids of the herb of Serratula coronata, and to reveal differences in the chemical composition of this plant population in comparison with information previously described in the literature. As a result of the study, five phytoecdysteroids were isolated from the herb of Serratula coronata - four from the polar (n-butanol) fraction and one from the non-polar (chloroform) fraction. Using NMR spectroscopy, it was found that the main isolated ecdysteroids are: 20-hydroxyecdysone (1) - 78±0.9% of the total amount of isolated compounds, augasterone C (2) - 11%, α-ecdysone (3) - 6% and taxisterone (4) - 1.2%. A new, previously unidentified ecdysteroid (5), 20,22-(but-2-ylidene) 20-hydroxyecdysone, was isolated from the low-polarity (chloroform) fraction. The studies were carried out as part of the implementation of the research plan of the VILAR Federal State Budgetary Scientific Institution on the topic №0576-2019-0010 "Search for active fractions of natural compounds, development of methods for their production from plant materials, standardization methods and the creation of modern dosage forms based on them".
Druh dokumentu: Article
Jazyk: Russian
ISSN: 2309-6039
DOI: 10.34907/jpqai.2020.60.39.005
Přístupové číslo: edsair.doi...........1700facd2855694851a505bcedca8258
Databáze: OpenAIRE
Popis
Abstrakt:Серпуха венценосная – растение-продуцент экдистероидов, представляющее интерес для внедрения в фармацевтическую практику и разработки лекарственных средств адаптогенного действия. В результате хроматографического разделения из надземной части серпухи венценосной (Serratula coronata L.), интродуцированной в Ботаническом саду ВИЛАР, было выделено пять основных экдистероидов, идентифицированных на основании данных ЯМР-спектроскопии. Подтверждено присутствие в серпухе венценосной четырех ранее идентифицированных соединений: 20-гидроксиэкдизона (1), аюгастерона С (2), α-экдизона (3) и таксистерона (4). Впервые выделено новое соединение - 20,22-пропиледен 20-гидроксиэкдизона (5). Ecdysteroids are triterpene compounds with four condensed rings having 27 or 28-29 carbon atoms. Ecdysteroids are widespread in the flora and fauna and have a wide spectrum of pharmacological activity. Low toxicity and high biological activity are the main indicators of the prospects for the use of drugs based on phytoecdysteroids. Serratula coronata L. - Asteraceae, containing a significant amount of ecditseroids, is an object of particular interest. The purpose of this investigation was to isolate and identify the main (dominant) phytoecdysteroids of the herb of Serratula coronata, and to reveal differences in the chemical composition of this plant population in comparison with information previously described in the literature. As a result of the study, five phytoecdysteroids were isolated from the herb of Serratula coronata - four from the polar (n-butanol) fraction and one from the non-polar (chloroform) fraction. Using NMR spectroscopy, it was found that the main isolated ecdysteroids are: 20-hydroxyecdysone (1) - 78±0.9% of the total amount of isolated compounds, augasterone C (2) - 11%, α-ecdysone (3) - 6% and taxisterone (4) - 1.2%. A new, previously unidentified ecdysteroid (5), 20,22-(but-2-ylidene) 20-hydroxyecdysone, was isolated from the low-polarity (chloroform) fraction. The studies were carried out as part of the implementation of the research plan of the VILAR Federal State Budgetary Scientific Institution on the topic №0576-2019-0010 "Search for active fractions of natural compounds, development of methods for their production from plant materials, standardization methods and the creation of modern dosage forms based on them".
ISSN:23096039
DOI:10.34907/jpqai.2020.60.39.005