Evaluation of transrectal ultrasound-guided tru-cut biopsy as a complementary method for predicting pathological complete response in rectal cancer after neoadjuvant treatment: a phase II prospective and diagnostic trial.
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| Titel: | Evaluation of transrectal ultrasound-guided tru-cut biopsy as a complementary method for predicting pathological complete response in rectal cancer after neoadjuvant treatment: a phase II prospective and diagnostic trial. |
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| Autoren: | Yaoyi Huang1,2,3, Yumo Xie1,2,3, Puning Wang1,2,3, Yao Chen4, Si Qin4, Fangqian Li5, Yuanhui Wu1,2,3, Mingzhe Huang1,2,3, Zehui Hou1,2,3, Yonghua Cai1,2,3, Xiaosheng He1,2,3, Hongcheng Lin1,2,3, Bang Hu1,2,3, Qiyuan Qin1,2,3, Tenghui Ma1,2,3, Shuyun Tan1,2,3, Yi Liao1,2,3, Jia Ke1,2,3, Di Zhang1,2,3, Sicong Lai1,2,3 |
| Quelle: | International Journal of Surgery. Jun2024, Vol. 110 Issue 6, p3230-3236. 7p. |
| Abstract: | Importance: Patients with pathological complete response (pCR) of rectal cancer following neoadjuvant treatment had better oncological outcomes. However, reliable methods for accurately predicting pCR remain limited. Objective: To evaluate whether transrectal ultrasound-guided tru-cut biopsy (TRUS-TCB) adds diagnostic value to conventional modalities for predicting pathological complete response in patients with rectal cancer after neoadjuvant treatment. Design, setting, and participants: This study evaluated data of patients with rectal cancer who were treated with neoadjuvant treatment and reassessed using TRUS-TCB and conventional modalities before surgery. This study is registered with ClinicalTrials.gov. Main outcomes and measures: The primary outcome was accuracy, along with secondary outcomes including sensitivity, specificity, negative predictive value, and positive predictive value in predicting tumour residues. Final surgical pathology was used as reference standard. Results: Between June 2021 and June 2022, a total of 74 patients were enroled, with 63 patients ultimately evaluated. Among them, 17 patients (28%) exhibited a complete pathological response. TRUS-TCB demonstrated an accuracy of 0.71 (95% CI, 0.58-0.82) in predicting tumour residues. The combined use of TRUS-TCB and conventional modalities significantly improved diagnostic accuracy compared to conventional modalities alone (0.75 vs. 0.59, P = 0.02). Furthermore, TRUS-TCB correctly reclassified 52% of patients erroneously classified as having a complete clinical response by conventional methods. The occurrence of only one mild adverse event was observed. Conclusions and relevance: TRUS-TCB proves to be a safe and accessible tool for reevaluation with minimal complications. The incorporation of TRUS-TCB alongside conventional methods leads to enhanced diagnostic performance. [ABSTRACT FROM AUTHOR] |
| Datenbank: | Supplemental Index |
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| Header | DbId: edo DbLabel: Supplemental Index An: 179864577 RelevancyScore: 983 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 983.424133300781 |
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| Items | – Name: Title Label: Title Group: Ti Data: Evaluation of transrectal ultrasound-guided tru-cut biopsy as a complementary method for predicting pathological complete response in rectal cancer after neoadjuvant treatment: a phase II prospective and diagnostic trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yaoyi+Huang%22">Yaoyi Huang</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yumo+Xie%22">Yumo Xie</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Puning+Wang%22">Puning Wang</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yao+Chen%22">Yao Chen</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Si+Qin%22">Si Qin</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Fangqian+Li%22">Fangqian Li</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Yuanhui+Wu%22">Yuanhui Wu</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Mingzhe+Huang%22">Mingzhe Huang</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Zehui+Hou%22">Zehui Hou</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yonghua+Cai%22">Yonghua Cai</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Xiaosheng+He%22">Xiaosheng He</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Hongcheng+Lin%22">Hongcheng Lin</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bang+Hu%22">Bang Hu</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Qiyuan+Qin%22">Qiyuan Qin</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Tenghui+Ma%22">Tenghui Ma</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Shuyun+Tan%22">Shuyun Tan</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yi+Liao%22">Yi Liao</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Jia+Ke%22">Jia Ke</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Di+Zhang%22">Di Zhang</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Sicong+Lai%22">Sicong Lai</searchLink><relatesTo>1,2,3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Surgery%22">International Journal of Surgery</searchLink>. Jun2024, Vol. 110 Issue 6, p3230-3236. 7p. – Name: Abstract Label: Abstract Group: Ab Data: Importance: Patients with pathological complete response (pCR) of rectal cancer following neoadjuvant treatment had better oncological outcomes. However, reliable methods for accurately predicting pCR remain limited. Objective: To evaluate whether transrectal ultrasound-guided tru-cut biopsy (TRUS-TCB) adds diagnostic value to conventional modalities for predicting pathological complete response in patients with rectal cancer after neoadjuvant treatment. Design, setting, and participants: This study evaluated data of patients with rectal cancer who were treated with neoadjuvant treatment and reassessed using TRUS-TCB and conventional modalities before surgery. This study is registered with ClinicalTrials.gov. Main outcomes and measures: The primary outcome was accuracy, along with secondary outcomes including sensitivity, specificity, negative predictive value, and positive predictive value in predicting tumour residues. Final surgical pathology was used as reference standard. Results: Between June 2021 and June 2022, a total of 74 patients were enroled, with 63 patients ultimately evaluated. Among them, 17 patients (28%) exhibited a complete pathological response. TRUS-TCB demonstrated an accuracy of 0.71 (95% CI, 0.58-0.82) in predicting tumour residues. The combined use of TRUS-TCB and conventional modalities significantly improved diagnostic accuracy compared to conventional modalities alone (0.75 vs. 0.59, P = 0.02). Furthermore, TRUS-TCB correctly reclassified 52% of patients erroneously classified as having a complete clinical response by conventional methods. The occurrence of only one mild adverse event was observed. Conclusions and relevance: TRUS-TCB proves to be a safe and accessible tool for reevaluation with minimal complications. The incorporation of TRUS-TCB alongside conventional methods leads to enhanced diagnostic performance. [ABSTRACT FROM AUTHOR] |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1097/JS9.0000000000001152 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 3230 Titles: – TitleFull: Evaluation of transrectal ultrasound-guided tru-cut biopsy as a complementary method for predicting pathological complete response in rectal cancer after neoadjuvant treatment: a phase II prospective and diagnostic trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yaoyi Huang – PersonEntity: Name: NameFull: Yumo Xie – PersonEntity: Name: NameFull: Puning Wang – PersonEntity: Name: NameFull: Yao Chen – PersonEntity: Name: NameFull: Si Qin – PersonEntity: Name: NameFull: Fangqian Li – PersonEntity: Name: NameFull: Yuanhui Wu – PersonEntity: Name: NameFull: Mingzhe Huang – PersonEntity: Name: NameFull: Zehui Hou – PersonEntity: Name: NameFull: Yonghua Cai – PersonEntity: Name: NameFull: Xiaosheng He – PersonEntity: Name: NameFull: Hongcheng Lin – PersonEntity: Name: NameFull: Bang Hu – PersonEntity: Name: NameFull: Qiyuan Qin – PersonEntity: Name: NameFull: Tenghui Ma – PersonEntity: Name: NameFull: Shuyun Tan – PersonEntity: Name: NameFull: Yi Liao – PersonEntity: Name: NameFull: Jia Ke – PersonEntity: Name: NameFull: Di Zhang – PersonEntity: Name: NameFull: Sicong Lai IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 17439191 Numbering: – Type: volume Value: 110 – Type: issue Value: 6 Titles: – TitleFull: International Journal of Surgery Type: main |
| ResultId | 1 |