Zobrazit v EDS

Viral codon usage and the virus-host interactions.

Uloženo v:
Podrobná bibliografie
Název: Viral codon usage and the virus-host interactions.
Autoři: Sirihongthong, Thanyaporn, Auewarakul, Prasert
Zdroj: Frontiers in Microbiology; 2025, p1-9, 9p
Témata: HOST-virus relationships, VIRAL genetics, GENETIC code, GENETICS, VIRAL ecology, PROTEIN synthesis
Abstrakt: Codon usage pattern is a specific characteristic of each species as a result of evolution and interaction between genome composition and translational machinery. Species-specific optimal codon usage is a requirement for efficient expression in cells of that species. Viruses pose a curious situation where their genomes must interact with their hosts. Codon usage and genome composition of most viruses infecting eukaryotic hosts are markedly different from those of their hosts. How these viruses efficiently express their genes with non-optimal codon usage is not well understood. Some evidence suggests that they may manipulate host translational machinery to achieve this. On the other hand, host cells may launch innate antiviral defense to suppress expression of viral genes with non-optimal codon usage. Codon usages of viruses are more similar among viruses within the same genome type. This suggests that there may be common mechanisms driving codon usage of viruses within the same genome type. These interactions may contribute to host adaptation in inter-species transmission and viral emergence. However, direct adaptation to be more similar with host codon usage pattern is not always the case. Complex viral-host interaction may direct evolution of viral codon usage. More understanding in these interactions may provide new insight into the viral evolution and host adaptation and offer new possibilities in fighting against new and old viruses. Here we review various aspects of these interactions. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Microbiology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Databáze: Biomedical Index
Popis
Abstrakt:Codon usage pattern is a specific characteristic of each species as a result of evolution and interaction between genome composition and translational machinery. Species-specific optimal codon usage is a requirement for efficient expression in cells of that species. Viruses pose a curious situation where their genomes must interact with their hosts. Codon usage and genome composition of most viruses infecting eukaryotic hosts are markedly different from those of their hosts. How these viruses efficiently express their genes with non-optimal codon usage is not well understood. Some evidence suggests that they may manipulate host translational machinery to achieve this. On the other hand, host cells may launch innate antiviral defense to suppress expression of viral genes with non-optimal codon usage. Codon usages of viruses are more similar among viruses within the same genome type. This suggests that there may be common mechanisms driving codon usage of viruses within the same genome type. These interactions may contribute to host adaptation in inter-species transmission and viral emergence. However, direct adaptation to be more similar with host codon usage pattern is not always the case. Complex viral-host interaction may direct evolution of viral codon usage. More understanding in these interactions may provide new insight into the viral evolution and host adaptation and offer new possibilities in fighting against new and old viruses. Here we review various aspects of these interactions. [ABSTRACT FROM AUTHOR]
ISSN:1664302X
DOI:10.3389/fmicb.2025.1711603