SYNTHESIS AND CHARACTERIZATION OF MIXED HYBRID LANTHANIDE COMPLEX.
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| Název: | SYNTHESIS AND CHARACTERIZATION OF MIXED HYBRID LANTHANIDE COMPLEX. |
|---|---|
| Autoři: | Kadam, S. S., Bhattar, S. L., Dhale, B. B., Varale, A. S., Yamgar, B. A., Pawar, D. K. |
| Zdroj: | Biochemical & Cellular Archives; Oct2025, Vol. 25 Issue 2, p1961-1969, 9p |
| Témata: | ANTIBACTERIAL agents, ANTIFUNGAL agents, DRUG development, MALARIA, MATERIALS testing, RARE earth metals, CHEMICAL synthesis, ANTI-infective agents |
| Abstrakt: | Lanthanide metal complexes were synthesized using a classical condensation method by reacting lanthanide nitrate salts with a bidentate ligand in a 1:2:1 molar ratio (M:L:L). The formation and structure of the resulting complexes were confirmed through a combination of analytical techniques, including infrared (IR) spectroscopy, thermal gravimetric analysis (TGA), X-ray diffraction (XRD), elemental microanalysis and scanning electron microscopy (SEM). The free ligand was also characterized using IR, SEM, XRD, TGA, fluorescence spectroscopy, and subjected to microbial screening. The synthesized lanthanide complexes were evaluated for their in-vitro antibacterial activity against gram-positive strains (Streptococcus pyogenes, Staphylococcus aureus) and gram-negative strains (Escherichia coli, Pseudomonas aeruginosa). Antifungal activity was assessed against Candida albicans, Aspergillus niger and Aspergillus clavatus, while antimalarial efficacy was tested against Plasmodium falciparum. The antimicrobial screening results revealed that the lanthanide complexes exhibited significant antibacterial and antifungal activity, surpassing the effectiveness of several standard drugs. These findings highlight the potential of lanthanide complexes as promising candidates for antimicrobial and antimalarial drug development. [ABSTRACT FROM AUTHOR] |
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| Databáze: | Biomedical Index |
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