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Ex-Situ Dual Hypothermic Oxygenated Machine Perfusion in Full-Left-Full-Right Split Liver Transplantation for Two Adult Recipients.

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Titel: Ex-Situ Dual Hypothermic Oxygenated Machine Perfusion in Full-Left-Full-Right Split Liver Transplantation for Two Adult Recipients.
Autoren: Kobryń, Konrad, Frankowska, Aleksandra, Rykowski, Paweł, Bartkowiak, Mateusz, Zhylko, Andriej, Morawski, Marcin, Stypułkowski, Jan, Masior, Łukasz, Smoter, Piotr, Patkowski, Waldemar, Grąt, Michał
Quelle: Journal of Clinical Medicine; Sep2025, Vol. 14 Issue 18, p6596, 19p
Schlagwörter: LIVER transplantation, REPERFUSION injury, ADULTS, ARTIFICIAL blood circulation, TRANSPLANTATION of organs, tissues, etc., GRAFT survival, PERFUSION
Abstract: Background/Objectives: The shortage of liver grafts remains a major challenge in transplantation. Full-left-full-right (FLFR) split liver transplantation (SLT) expands the donor pool by providing two grafts for small adult recipients. However, prolonged cold ischemia time (CIT) and ischemia-reperfusion injury (IRI) limit its success. Methods: We report a case of FLFR SLT utilizing ex situ dual hypothermic oxygenated machine perfusion (DHOPE) to mitigate IRI and enhance graft viability. A brain-dead donor's liver was split under continuous DHOPE, followed by simultaneous transplantation into two adult recipients. Results: Both recipients exhibited stable graft function at one-year follow-up. DHOPE effectively reduced CIT and optimized postoperative recovery, with no major complications beyond Clavien–Dindo Grade IIIb. Conclusions: This is the first reported FLFR SLT using ex situ DHOPE for two adult recipients, demonstrating its feasibility in reducing CIT and improving outcomes. Machine perfusion may become a standard in FLFR SLT. [ABSTRACT FROM AUTHOR]
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  Label: Title
  Group: Ti
  Data: Ex-Situ Dual Hypothermic Oxygenated Machine Perfusion in Full-Left-Full-Right Split Liver Transplantation for Two Adult Recipients.
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  Data: <searchLink fieldCode="AR" term="%22Kobryń%2C+Konrad%22">Kobryń, Konrad</searchLink><br /><searchLink fieldCode="AR" term="%22Frankowska%2C+Aleksandra%22">Frankowska, Aleksandra</searchLink><br /><searchLink fieldCode="AR" term="%22Rykowski%2C+Paweł%22">Rykowski, Paweł</searchLink><br /><searchLink fieldCode="AR" term="%22Bartkowiak%2C+Mateusz%22">Bartkowiak, Mateusz</searchLink><br /><searchLink fieldCode="AR" term="%22Zhylko%2C+Andriej%22">Zhylko, Andriej</searchLink><br /><searchLink fieldCode="AR" term="%22Morawski%2C+Marcin%22">Morawski, Marcin</searchLink><br /><searchLink fieldCode="AR" term="%22Stypułkowski%2C+Jan%22">Stypułkowski, Jan</searchLink><br /><searchLink fieldCode="AR" term="%22Masior%2C+Łukasz%22">Masior, Łukasz</searchLink><br /><searchLink fieldCode="AR" term="%22Smoter%2C+Piotr%22">Smoter, Piotr</searchLink><br /><searchLink fieldCode="AR" term="%22Patkowski%2C+Waldemar%22">Patkowski, Waldemar</searchLink><br /><searchLink fieldCode="AR" term="%22Grąt%2C+Michał%22">Grąt, Michał</searchLink>
– Name: TitleSource
  Label: Source
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  Data: Journal of Clinical Medicine; Sep2025, Vol. 14 Issue 18, p6596, 19p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22LIVER+transplantation%22">LIVER transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22REPERFUSION+injury%22">REPERFUSION injury</searchLink><br /><searchLink fieldCode="DE" term="%22ADULTS%22">ADULTS</searchLink><br /><searchLink fieldCode="DE" term="%22ARTIFICIAL+blood+circulation%22">ARTIFICIAL blood circulation</searchLink><br /><searchLink fieldCode="DE" term="%22TRANSPLANTATION+of+organs%2C+tissues%2C+etc%2E%22">TRANSPLANTATION of organs, tissues, etc.</searchLink><br /><searchLink fieldCode="DE" term="%22GRAFT+survival%22">GRAFT survival</searchLink><br /><searchLink fieldCode="DE" term="%22PERFUSION%22">PERFUSION</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background/Objectives: The shortage of liver grafts remains a major challenge in transplantation. Full-left-full-right (FLFR) split liver transplantation (SLT) expands the donor pool by providing two grafts for small adult recipients. However, prolonged cold ischemia time (CIT) and ischemia-reperfusion injury (IRI) limit its success. Methods: We report a case of FLFR SLT utilizing ex situ dual hypothermic oxygenated machine perfusion (DHOPE) to mitigate IRI and enhance graft viability. A brain-dead donor's liver was split under continuous DHOPE, followed by simultaneous transplantation into two adult recipients. Results: Both recipients exhibited stable graft function at one-year follow-up. DHOPE effectively reduced CIT and optimized postoperative recovery, with no major complications beyond Clavien–Dindo Grade IIIb. Conclusions: This is the first reported FLFR SLT using ex situ DHOPE for two adult recipients, demonstrating its feasibility in reducing CIT and improving outcomes. Machine perfusion may become a standard in FLFR SLT. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.3390/jcm14186596
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      – Code: eng
        Text: English
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        PageCount: 19
        StartPage: 6596
    Subjects:
      – SubjectFull: LIVER transplantation
        Type: general
      – SubjectFull: REPERFUSION injury
        Type: general
      – SubjectFull: ADULTS
        Type: general
      – SubjectFull: ARTIFICIAL blood circulation
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      – SubjectFull: TRANSPLANTATION of organs, tissues, etc.
        Type: general
      – SubjectFull: GRAFT survival
        Type: general
      – SubjectFull: PERFUSION
        Type: general
    Titles:
      – TitleFull: Ex-Situ Dual Hypothermic Oxygenated Machine Perfusion in Full-Left-Full-Right Split Liver Transplantation for Two Adult Recipients.
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              M: 09
              Text: Sep2025
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              Y: 2025
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