Podrobná bibliografie
| Název: |
A Case Series of Extensively Drug-Resistant Tuberculosis: Treatment Response and Risk Factor Profile from a Tertiary Care Center in Karachi. |
| Autoři: |
Batool, Farzana, Ahmed, Iftekhar, Siddiqui, Sana, Qureshi, Muzaiyyena |
| Zdroj: |
Pakistan Journal of Chest Medicine; Jul-Sep2025, Vol. 31 Issue 3, p265-270, 6p |
| Témata: |
ANTIBIOTICS, SPUTUM microbiology, RISK assessment, PUBLIC hospitals, QUINOLINE, HETEROCYCLIC compounds, PYRAZINAMIDE, FLUOROQUINOLONES, ISONIAZID, ACADEMIC medical centers, TERTIARY care, RETROSPECTIVE studies, TREATMENT effectiveness, DESCRIPTIVE statistics, TREATMENT duration, ANTITUBERCULAR agents, DRUG efficacy, MEDICAL records, ACQUISITION of data, DISEASE complications, PYRIDINE, AMIKACIN, CASE studies, INDIVIDUALIZED medicine, LINEZOLID, DATA analysis software, KANAMYCIN, PATIENT aftercare, EVALUATION |
| Geografický termín: |
PAKISTAN |
| Abstrakt: |
Background: Tuberculosis is a growing public health concern in Pakistan. The increasing burden of drug-resistant TB poses a major threat nationwide. Lack of awareness, demographic factors, illiteracy, and inadequate healthcare facilities contribute significantly to its spread. Objective: To evaluate the outcome of treated extensively drug-resistant tuberculosis (XDR-TB) patients registered at the Odisha Institute of Chest Diseases (OICD), a tertiary care hospital. Methodology: This is a retrospective case-series study conducted on patients registered for extensively drug-resistant tuberculosis (XDR-TB) treatment from January 2017 to January 2021. All data was extracted on Excel sheets. Appropriate statistical methods were employed using Statistical Package for Social Sciences (SPSS) to analyze the frequencies and percentages. Results: In the present case series, 5 patients were included according to the criteria for XDR-TB patients, of whom 3 were male and 2 were female. Treatment lasted for 24 months; 4 were declared completed upon showing sputum conversion, while 1 was declared dead. No adverse effects were observed. Conclusion: In conclusion, the management of drug-resistant tuberculosis poses significant challenges, highlighting the vital importance of tailored treatment strategies and vigilant surveillance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains necessitates innovative approaches, such as the utilization of second-line medications like bedaquiline and delamanid, in order to achieve successful outcomes. [ABSTRACT FROM AUTHOR] |
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| Databáze: |
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