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Validation of the investigator argus y-28 qs kit on the seqstudio™ genetic analyzer for hid: a new panel file for genemapper id-x software v1.6.

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Název: Validation of the investigator argus y-28 qs kit on the seqstudio™ genetic analyzer for hid: a new panel file for genemapper id-x software v1.6.
Autoři: Soldati, Giulia, Turrina, Stefania, Ausania, Francesco
Zdroj: International Journal of Legal Medicine; Nov2025, Vol. 139 Issue 6, p2635-2645, 11p
Témata: MICROSATELLITE repeats, DNA fingerprinting, FORENSIC genetics, GENETIC software, STATISTICAL accuracy, RESEARCH evaluation, SENSITIVITY & specificity (Statistics)
Abstrakt: Background: The Investigator Argus Y-28 QS Kit is a 27-locus, six-dye multiplex, which includes six rapidly mutating Short Tandem Repeats (RM Y-STRs). Methods: A new text file containing the optimized panel and bin sets for GeneMapper ID-X Software v1.6 has been prepared. In addition, an internal validation study was conducted on the Investigator Argus Y-28 QS kit using the SeqStudio™ Genetic Analyzer for HID. Results: The full results of that study are presented here, including data on precision, sensitivity, reproducibility, stutter determination, and reduction volume analysis. A concordance study and three case reports are documented. Finally, the kit was successfully used to conduct a proficiency test. Conclusions: The obtained findings achieved a satisfactory performance of the Investigator Argus Y-28 QS Kit on the SeqStudio™ Genetic Analyzer for HID. [ABSTRACT FROM AUTHOR]
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Databáze: Complementary Index
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Abstrakt:Background: The Investigator Argus Y-28 QS Kit is a 27-locus, six-dye multiplex, which includes six rapidly mutating Short Tandem Repeats (RM Y-STRs). Methods: A new text file containing the optimized panel and bin sets for GeneMapper ID-X Software v1.6 has been prepared. In addition, an internal validation study was conducted on the Investigator Argus Y-28 QS kit using the SeqStudio™ Genetic Analyzer for HID. Results: The full results of that study are presented here, including data on precision, sensitivity, reproducibility, stutter determination, and reduction volume analysis. A concordance study and three case reports are documented. Finally, the kit was successfully used to conduct a proficiency test. Conclusions: The obtained findings achieved a satisfactory performance of the Investigator Argus Y-28 QS Kit on the SeqStudio™ Genetic Analyzer for HID. [ABSTRACT FROM AUTHOR]
ISSN:09379827
DOI:10.1007/s00414-025-03539-6