View in EDS

Periodontal disease and chronic kidney disease: mechanistic insights and novel therapeutic perspectives.

Saved in:
Bibliographic Details
Title: Periodontal disease and chronic kidney disease: mechanistic insights and novel therapeutic perspectives.
Authors: Li, Shuxin, Cao, Hongliang, Zhang, Yueqiu, Wang, Fulin, Huang, Gengchen, Wang, Binbin, Wei, Wei, Wang, Gang
Source: Frontiers in Cellular & Infection Microbiology; 2025, p1-14, 14p
Subject Terms: PERIODONTAL disease, CHRONIC kidney failure, SYSTEMS theory, PATHOGENESIS, TREATMENT effectiveness, ORAL health, THERAPEUTICS, INFLAMMATION
Abstract: Periodontal disease (PD) is one of the most common chronic diseases of the oral cavity, and it usually refers to chronic inflammatory diseases caused by the infection of pathogenic microorganisms in the oral cavity. PD mainly affects the tissues around the teeth, causing inflammation of the gums and periodontium, destroying the alveolar bone, and even leading to tooth loosening. Many studies have shown that PD is not only limited to oral health but is also associated with diseases of multiple systems throughout the body. In recent years, more and more studies have focused on the interaction between PD and urologic diseases, especially chronic kidney disease (CKD). PD is also a typical oral disease frequently observed in patients with kidney disease. This paper reviews the potential link between PD and CKD and discusses the interaction's pathologic mechanisms and clinical implications. In addition, this review aims to identify possible pathogenic mechanisms and suggest potential ways to target PD to prevent and treat CKD. This would lead to better treatment options to delay the progression of CKD. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Cellular & Infection Microbiology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
Description
Abstract:Periodontal disease (PD) is one of the most common chronic diseases of the oral cavity, and it usually refers to chronic inflammatory diseases caused by the infection of pathogenic microorganisms in the oral cavity. PD mainly affects the tissues around the teeth, causing inflammation of the gums and periodontium, destroying the alveolar bone, and even leading to tooth loosening. Many studies have shown that PD is not only limited to oral health but is also associated with diseases of multiple systems throughout the body. In recent years, more and more studies have focused on the interaction between PD and urologic diseases, especially chronic kidney disease (CKD). PD is also a typical oral disease frequently observed in patients with kidney disease. This paper reviews the potential link between PD and CKD and discusses the interaction's pathologic mechanisms and clinical implications. In addition, this review aims to identify possible pathogenic mechanisms and suggest potential ways to target PD to prevent and treat CKD. This would lead to better treatment options to delay the progression of CKD. [ABSTRACT FROM AUTHOR]
ISSN:22352988
DOI:10.3389/fcimb.2025.1611097