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Monocyte/HDL Cholesterol Ratio and Matrix Metalloproteinase-2 in Obstructive Sleep Apnea Syndrome Without Heart Disease.

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Názov: Monocyte/HDL Cholesterol Ratio and Matrix Metalloproteinase-2 in Obstructive Sleep Apnea Syndrome Without Heart Disease.
Autori: Külah, Gökçe, Şaylan, Bengü, Başlılar, Şeyma, Çalışkan, Tayfun
Zdroj: Journal of Turkish Sleep Medicine; Jun2025, Vol. 12 Issue 2, p1-7, 7p
Predmety: HDL cholesterol, CROSS-sectional method, MONOCYTES, SEVERITY of illness index, DESCRIPTIVE statistics, MULTIVARIATE analysis, SLEEP apnea syndromes, MATRIX metalloproteinases, EARLY diagnosis, SENSITIVITY & specificity (Statistics), DISEASE risk factors
Abstrakt: Objective Long waiting periods for polysomnography (PSG) may delay the diagnosis of obstructive sleep apnea syndrome. We aimed to assess the value of the serum monocyte/high-density lipoprotein (HDL) cholesterol ratio and matrix metalloproteinase-2 (MMP-2) levels in the early diagnosis and determination of disease severity. Materials and Methods This cross-sectional analytical study enrolled 162 adult participants-31 with mild, 38 with moderate, and 47 with severe disease and 46 non-affected controls. The clinical and demographic data and the ratio and MMP-2 levels were recorded and compared. Results A ratio >8.78 discriminated between cases with and without the condition, with a 73.3% sensitivity and 60.9% specificity (p=0.004). A serum MMP-2 level ≤4.01 ng/mL was also effective, with a 75% sensitivity and 50% specificity (p=0.012). There was a significant positive correlation between the serum monocyte/HDL cholesterol ratio and disease severity, with a 38% sensitivity and 92% specificity (p=0.025), but an insignificant negative correlation with (MMP-2) level. The ratio, but not MMP-2 level, was significantly higher in affected subgroups than in the controls. Reanalysis of risk factors using a multivariate model revealed that higher HDL and metalloproteinase-2 levels were associated with a decreased likelihood of developing the condition. Conclusion Assessment of the serum monocyte/HDL cholesterol ratio and MMP-2 levels may be useful as rapid and low-cost methods for identifying the condition, and the former may help predict disease severity. Evaluation of these parameters may help plan PSG when obstructive sleep apnea is suspected. Keywords:Cholesterol, matrix metalloproteinase-2, monocytes, obstructive sleep apnea syndrome: [ABSTRACT FROM AUTHOR]
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Databáza: Complementary Index
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Abstrakt:Objective Long waiting periods for polysomnography (PSG) may delay the diagnosis of obstructive sleep apnea syndrome. We aimed to assess the value of the serum monocyte/high-density lipoprotein (HDL) cholesterol ratio and matrix metalloproteinase-2 (MMP-2) levels in the early diagnosis and determination of disease severity. Materials and Methods This cross-sectional analytical study enrolled 162 adult participants-31 with mild, 38 with moderate, and 47 with severe disease and 46 non-affected controls. The clinical and demographic data and the ratio and MMP-2 levels were recorded and compared. Results A ratio >8.78 discriminated between cases with and without the condition, with a 73.3% sensitivity and 60.9% specificity (p=0.004). A serum MMP-2 level ≤4.01 ng/mL was also effective, with a 75% sensitivity and 50% specificity (p=0.012). There was a significant positive correlation between the serum monocyte/HDL cholesterol ratio and disease severity, with a 38% sensitivity and 92% specificity (p=0.025), but an insignificant negative correlation with (MMP-2) level. The ratio, but not MMP-2 level, was significantly higher in affected subgroups than in the controls. Reanalysis of risk factors using a multivariate model revealed that higher HDL and metalloproteinase-2 levels were associated with a decreased likelihood of developing the condition. Conclusion Assessment of the serum monocyte/HDL cholesterol ratio and MMP-2 levels may be useful as rapid and low-cost methods for identifying the condition, and the former may help predict disease severity. Evaluation of these parameters may help plan PSG when obstructive sleep apnea is suspected. Keywords:Cholesterol, matrix metalloproteinase-2, monocytes, obstructive sleep apnea syndrome: [ABSTRACT FROM AUTHOR]
ISSN:21481504
DOI:10.4274/jtsm.galenos.2025.81542