Podrobná bibliografie
| Název: |
Profile of Inflammatory Cytokines in Gingival Crevicular Fluid and Plasma in Patients With Grade C Periodontitis During Orthodontic Treatment: A Longitudinal Case Series Report. |
| Autoři: |
Xin, Tian‐yi, Zhu, Zi‐lu, Chen, Liu‐jing, Han, Bin, Yang, Rui‐li, Shi, Jie |
| Zdroj: |
Orthodontics & Craniofacial Research; Apr2025, Vol. 28 Issue 2, p324-335, 12p |
| Témata: |
INTERLEUKIN-17, TUMOR necrosis factor receptors, AGGRESSIVE periodontitis, IMMUNE response, BLOOD plasma, GINGIVAL fluid, CORRECTIVE orthodontics, CYTOKINES |
| Abstrakt: |
Aim: To examine the immune responses in patients diagnosed as grade C periodontitis during orthodontic treatment. Materials and Methods: Our study included seven orthodontic patients with grade C periodontitis and measured their levels of inflammatory cytokines in gingival crevicular fluid and plasma before orthodontic treatment, during the alignment and levelling phase, and during the detailing and finishing phase. The key signal pathways in the orthodontic process of patients with periodontitis were detected by KEGG analysis. Results: Studies have shown that orthodontic treatment brings great improvement to patients with grade C periodontitis, and most of the local/systemic inflammatory cytokines can be reduced after orthodontic treatment. Simultaneously, orthodontic treatment can reduce the percentage of IFN‐γ+ Th1 cells in patients with grade C periodontitis. Through KEGG analysis, the IL‐17 signalling pathway and TNF signalling pathway are closely interrelated in the orthodontic treatment of patients diagnosed with grade C periodontitis (p‐value < 0.001). Conclusion: Orthodontic treatment can effectively control the local and system levels of inflammation in patients with grade C periodontitis, with IL‐17A and TNF‐α as potential distinctive inflammatory markers for orthodontic‐periodontal combined treatment in individuals with periodontitis. [ABSTRACT FROM AUTHOR] |
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