Profile of Inflammatory Cytokines in Gingival Crevicular Fluid and Plasma in Patients With Grade C Periodontitis During Orthodontic Treatment: A Longitudinal Case Series Report.
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| Titel: | Profile of Inflammatory Cytokines in Gingival Crevicular Fluid and Plasma in Patients With Grade C Periodontitis During Orthodontic Treatment: A Longitudinal Case Series Report. |
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| Autoren: | Xin, Tian‐yi, Zhu, Zi‐lu, Chen, Liu‐jing, Han, Bin, Yang, Rui‐li, Shi, Jie |
| Quelle: | Orthodontics & Craniofacial Research; Apr2025, Vol. 28 Issue 2, p324-335, 12p |
| Schlagwörter: | INTERLEUKIN-17, TUMOR necrosis factor receptors, AGGRESSIVE periodontitis, IMMUNE response, BLOOD plasma, GINGIVAL fluid, CORRECTIVE orthodontics, CYTOKINES |
| Abstract: | Aim: To examine the immune responses in patients diagnosed as grade C periodontitis during orthodontic treatment. Materials and Methods: Our study included seven orthodontic patients with grade C periodontitis and measured their levels of inflammatory cytokines in gingival crevicular fluid and plasma before orthodontic treatment, during the alignment and levelling phase, and during the detailing and finishing phase. The key signal pathways in the orthodontic process of patients with periodontitis were detected by KEGG analysis. Results: Studies have shown that orthodontic treatment brings great improvement to patients with grade C periodontitis, and most of the local/systemic inflammatory cytokines can be reduced after orthodontic treatment. Simultaneously, orthodontic treatment can reduce the percentage of IFN‐γ+ Th1 cells in patients with grade C periodontitis. Through KEGG analysis, the IL‐17 signalling pathway and TNF signalling pathway are closely interrelated in the orthodontic treatment of patients diagnosed with grade C periodontitis (p‐value < 0.001). Conclusion: Orthodontic treatment can effectively control the local and system levels of inflammation in patients with grade C periodontitis, with IL‐17A and TNF‐α as potential distinctive inflammatory markers for orthodontic‐periodontal combined treatment in individuals with periodontitis. [ABSTRACT FROM AUTHOR] |
| Copyright of Orthodontics & Craniofacial Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Datenbank: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Profile of Inflammatory Cytokines in Gingival Crevicular Fluid and Plasma in Patients With Grade C Periodontitis During Orthodontic Treatment: A Longitudinal Case Series Report. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Xin%2C+Tian‐yi%22">Xin, Tian‐yi</searchLink><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Zi‐lu%22">Zhu, Zi‐lu</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Liu‐jing%22">Chen, Liu‐jing</searchLink><br /><searchLink fieldCode="AR" term="%22Han%2C+Bin%22">Han, Bin</searchLink><br /><searchLink fieldCode="AR" term="%22Yang%2C+Rui‐li%22">Yang, Rui‐li</searchLink><br /><searchLink fieldCode="AR" term="%22Shi%2C+Jie%22">Shi, Jie</searchLink> – Name: TitleSource Label: Source Group: Src Data: Orthodontics & Craniofacial Research; Apr2025, Vol. 28 Issue 2, p324-335, 12p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22INTERLEUKIN-17%22">INTERLEUKIN-17</searchLink><br /><searchLink fieldCode="DE" term="%22TUMOR+necrosis+factor+receptors%22">TUMOR necrosis factor receptors</searchLink><br /><searchLink fieldCode="DE" term="%22AGGRESSIVE+periodontitis%22">AGGRESSIVE periodontitis</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNE+response%22">IMMUNE response</searchLink><br /><searchLink fieldCode="DE" term="%22BLOOD+plasma%22">BLOOD plasma</searchLink><br /><searchLink fieldCode="DE" term="%22GINGIVAL+fluid%22">GINGIVAL fluid</searchLink><br /><searchLink fieldCode="DE" term="%22CORRECTIVE+orthodontics%22">CORRECTIVE orthodontics</searchLink><br /><searchLink fieldCode="DE" term="%22CYTOKINES%22">CYTOKINES</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aim: To examine the immune responses in patients diagnosed as grade C periodontitis during orthodontic treatment. Materials and Methods: Our study included seven orthodontic patients with grade C periodontitis and measured their levels of inflammatory cytokines in gingival crevicular fluid and plasma before orthodontic treatment, during the alignment and levelling phase, and during the detailing and finishing phase. The key signal pathways in the orthodontic process of patients with periodontitis were detected by KEGG analysis. Results: Studies have shown that orthodontic treatment brings great improvement to patients with grade C periodontitis, and most of the local/systemic inflammatory cytokines can be reduced after orthodontic treatment. Simultaneously, orthodontic treatment can reduce the percentage of IFN‐γ+ Th1 cells in patients with grade C periodontitis. Through KEGG analysis, the IL‐17 signalling pathway and TNF signalling pathway are closely interrelated in the orthodontic treatment of patients diagnosed with grade C periodontitis (p‐value < 0.001). Conclusion: Orthodontic treatment can effectively control the local and system levels of inflammation in patients with grade C periodontitis, with IL‐17A and TNF‐α as potential distinctive inflammatory markers for orthodontic‐periodontal combined treatment in individuals with periodontitis. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Orthodontics & Craniofacial Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ocr.12880 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 324 Subjects: – SubjectFull: INTERLEUKIN-17 Type: general – SubjectFull: TUMOR necrosis factor receptors Type: general – SubjectFull: AGGRESSIVE periodontitis Type: general – SubjectFull: IMMUNE response Type: general – SubjectFull: BLOOD plasma Type: general – SubjectFull: GINGIVAL fluid Type: general – SubjectFull: CORRECTIVE orthodontics Type: general – SubjectFull: CYTOKINES Type: general Titles: – TitleFull: Profile of Inflammatory Cytokines in Gingival Crevicular Fluid and Plasma in Patients With Grade C Periodontitis During Orthodontic Treatment: A Longitudinal Case Series Report. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Xin, Tian‐yi – PersonEntity: Name: NameFull: Zhu, Zi‐lu – PersonEntity: Name: NameFull: Chen, Liu‐jing – PersonEntity: Name: NameFull: Han, Bin – PersonEntity: Name: NameFull: Yang, Rui‐li – PersonEntity: Name: NameFull: Shi, Jie IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 16016335 Numbering: – Type: volume Value: 28 – Type: issue Value: 2 Titles: – TitleFull: Orthodontics & Craniofacial Research Type: main |
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