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Design and Performance Evaluation of SiPM-based High-resolution Dedicated Brain Positron Emission Tomography Scanner: A Simulation Study.

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Název: Design and Performance Evaluation of SiPM-based High-resolution Dedicated Brain Positron Emission Tomography Scanner: A Simulation Study.
Autoři: Zare, Tahereh, Sheikhzadeh, Peyman, Teimourian Fard, Behnoosh, Ghafarian, Pardis, Ay, Mohammad Reza
Zdroj: Journal of Medical Physics; Oct-Dec2024, Vol. 49 Issue 4, p631-641, 11p
Témata: POSITRON emission tomography, MONTE Carlo method, BRAIN diseases, SCANNING systems, BASIC needs
Abstrakt: Purpose/Aim: The increasing population age highlights the critical need for early brain disease diagnosis, especially in disorders such as dementia. Consequently, a notable focus has been on developing dedicated brain positron emission tomography (PET) scanners, which offer higher resolution and sensitivity than whole-body PET scanners. This study aims to design and performance evaluation of an LYSO-based dedicated brain PET scanner. Materials and Methods: We developed a dedicated brain PET using Monte Carlo simulation based on cylindrical geometry. Each detector block consisted of a 23 × 23 array of 2 mm × 2 mm × 15 mm LYSO crystals coupled with SiPM. The performance of this scanner was evaluated based on the NEMA NU-2-2018 standard, focusing on analyzing various energy windows and coincidence time windows (CTWs). Results: The results demonstrated that the noise equivalent count rate (NECR) peaked at each CTW in the 408–680 keV energy window. In addition, increasing the CTWs from 3 ns to 10 ns resulted in a decrease of 9% in sensitivity and an increase of 63% in NECR. Furthermore, the study findings highlight that using a time-of-flight (TOF) resolution of 250 ps can substantially improve image contrast relative to non-TOF reconstruction. Conclusions: We conclude that employing a broader energy window and a narrower CTW can significantly enhance the scanner's performance regarding sensitivity and NECR. Furthermore, incorporating LYSO pixelated crystals with TOF information will facilitate the generation of high-resolution and high-contrast images. [ABSTRACT FROM AUTHOR]
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Abstrakt:Purpose/Aim: The increasing population age highlights the critical need for early brain disease diagnosis, especially in disorders such as dementia. Consequently, a notable focus has been on developing dedicated brain positron emission tomography (PET) scanners, which offer higher resolution and sensitivity than whole-body PET scanners. This study aims to design and performance evaluation of an LYSO-based dedicated brain PET scanner. Materials and Methods: We developed a dedicated brain PET using Monte Carlo simulation based on cylindrical geometry. Each detector block consisted of a 23 × 23 array of 2 mm × 2 mm × 15 mm LYSO crystals coupled with SiPM. The performance of this scanner was evaluated based on the NEMA NU-2-2018 standard, focusing on analyzing various energy windows and coincidence time windows (CTWs). Results: The results demonstrated that the noise equivalent count rate (NECR) peaked at each CTW in the 408–680 keV energy window. In addition, increasing the CTWs from 3 ns to 10 ns resulted in a decrease of 9% in sensitivity and an increase of 63% in NECR. Furthermore, the study findings highlight that using a time-of-flight (TOF) resolution of 250 ps can substantially improve image contrast relative to non-TOF reconstruction. Conclusions: We conclude that employing a broader energy window and a narrower CTW can significantly enhance the scanner's performance regarding sensitivity and NECR. Furthermore, incorporating LYSO pixelated crystals with TOF information will facilitate the generation of high-resolution and high-contrast images. [ABSTRACT FROM AUTHOR]
ISSN:09716203
DOI:10.4103/jmp.jmp_134_24