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Values of H-Type Hypertension in Patients with Large Vessel Occlusion.

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Title: Values of H-Type Hypertension in Patients with Large Vessel Occlusion.
Authors: Xie, Dongjing, Wan, Junfang, Guo, Changwei, Yang, Jie, Huang, Jiacheng, Peng, Zhouzhou, Huang, Jiandi, Li, Linyu, Fan, Shitao, Yang, Dahong, Sun, Wenzhe, Zi, Wenjie, Li, Fengli, Peng, Feng, Hu, Jinrong, Yang, Qingwu
Source: Clinical Interventions in Aging; Nov2024, Vol. 19, p1907-1917, 11p
Subject Terms: HYPERTENSION, ENDOVASCULAR surgery, CEREBRAL hemorrhage, STROKE patients, ODDS ratio
Abstract: Background and Purpose: Many patients who gained successful recanalization by endovascular treatment (EVT) with acute large vessel occlusion (LVO) did not have the favorable outcome. The study aimed to assess the association between H-type hypertension and clinical prognosis in patients with LVO after receiving EVT. Methods: Our study enrolled patients from the Endovascular Treatment With versus Without Tirofiban for Stroke Patients with Large Vessel Occlusion (RESCUE BT) Trial. H-type hypertension is defined as patients with hypertension and homocysteine (Hcy) ≥ 10μmol/L. The primary outcome was a favorable functional outcome, defined as a score of 0– 2 on the modified Rankin Scale (mRS) at 90 days. The secondary outcomes were mortality, successful recanalization, futile recanalization, and symptomatic intracerebral hemorrhage (sICH). Results: The plasma homocysteine level was recorded for 215 patients with hypertension in our study. Among those patients, 172 patients (80%) were founded with Hcy ≥ 10μmol/L (H-type hypertension), and 43 patients (20%) with Hcy < 10μmol/L (non-H-type hypertension). The probability of favorable outcome decreased with homocysteine increasing in patients with hypertension. H-type hypertension was associated with a low probability of favorable outcome (adjusted odds ratio (aOR), 0.38 [95% confidence interval (CI), 0.18– 0.80]; p = 0.01) at 90 days. The effects of H-type hypertension on mortality (aOR, 1.90 [95% CI, 0.67– 5.39]; p = 0.23) and sICH (aOR, 0.55 [95% CI, 0.13– 2.29]; p = 0.41) were not significant. Conclusion: Our findings suggest that patients with H-type hypertension have a lower likelihood of achieving favorable outcomes but do not have an increased mortality rate within 90 days. [ABSTRACT FROM AUTHOR]
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Abstract:Background and Purpose: Many patients who gained successful recanalization by endovascular treatment (EVT) with acute large vessel occlusion (LVO) did not have the favorable outcome. The study aimed to assess the association between H-type hypertension and clinical prognosis in patients with LVO after receiving EVT. Methods: Our study enrolled patients from the Endovascular Treatment With versus Without Tirofiban for Stroke Patients with Large Vessel Occlusion (RESCUE BT) Trial. H-type hypertension is defined as patients with hypertension and homocysteine (Hcy) ≥ 10μmol/L. The primary outcome was a favorable functional outcome, defined as a score of 0– 2 on the modified Rankin Scale (mRS) at 90 days. The secondary outcomes were mortality, successful recanalization, futile recanalization, and symptomatic intracerebral hemorrhage (sICH). Results: The plasma homocysteine level was recorded for 215 patients with hypertension in our study. Among those patients, 172 patients (80%) were founded with Hcy ≥ 10μmol/L (H-type hypertension), and 43 patients (20%) with Hcy < 10μmol/L (non-H-type hypertension). The probability of favorable outcome decreased with homocysteine increasing in patients with hypertension. H-type hypertension was associated with a low probability of favorable outcome (adjusted odds ratio (aOR), 0.38 [95% confidence interval (CI), 0.18– 0.80]; p = 0.01) at 90 days. The effects of H-type hypertension on mortality (aOR, 1.90 [95% CI, 0.67– 5.39]; p = 0.23) and sICH (aOR, 0.55 [95% CI, 0.13– 2.29]; p = 0.41) were not significant. Conclusion: Our findings suggest that patients with H-type hypertension have a lower likelihood of achieving favorable outcomes but do not have an increased mortality rate within 90 days. [ABSTRACT FROM AUTHOR]
ISSN:11769092
DOI:10.2147/CIA.S488000