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A prospective cohort study of persistent endocrine-disrupting chemicals and perceived stress.

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Title: A prospective cohort study of persistent endocrine-disrupting chemicals and perceived stress.
Authors: Schildroth, Samantha, Wesselink, Amelia K, Bethea, Traci N, Henn, Birgit Claus, Friedman, Alexa, Fruh, Victoria, Coleman, Chad M, Lovett, Sharonda M, Vines, Anissa I, Sjodin, Andreas, Botelho, Julianne Cook, Calafat, Antonia M, Wegienka, Ganesa, Weuve, Jennifer, Baird, Donna D, Wise, Lauren A
Source: American Journal of Epidemiology; Dec2024, Vol. 193 Issue 12, p1729-1740, 12p
Subject Terms: RISK assessment, POLYCHLORINATED biphenyls, AFRICAN Americans, REPRODUCTIVE health, RESEARCH funding, HYDROCARBONS, PSYCHOLOGY of women, PESTICIDES, LONGITUDINAL method, PSYCHOLOGICAL stress, ENVIRONMENTAL exposure, ENDOCRINE disruptors, ETHERS, FLUOROCARBONS, REGRESSION analysis
Geographic Terms: UNITED States
Abstract: Persistent endocrine-disrupting chemicals (EDCs) can dysregulate the stress response. We evaluated associations between persistent EDCs and perceived stress among participants in the Study of Environment, Lifestyle, and Fibroids (n  = 1394), a prospective cohort study of Black women. Participants completed the Perceived Stress Scale 4 (PSS-4) at baseline and every 20 months through 60 months (score range: 0-16); higher scores indicate higher stress. Endocrine-disrupting chemicals, including per- and polyfluoroalkyl substances, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides, were quantified in plasma samples at baseline. We fit bayesian kernel machine regression and linear mixed-effects models to estimate associations of EDCs (as a mixture and individually) with PSS-4 scores at baseline and at each follow-up visit, respectively. Increasing percentiles of the mixture were not strongly associated with PSS-4 scores at baseline, and no interactions were observed among EDCs. Several individual EDCs (eg, perfluorodecanoic acid, PCB 118, PBDE 99) were associated with higher PSS-4 scores at baseline or follow-up, and other EDCs (eg PCB 138/158) were associated with lower PSS-4 scores at baseline or follow-up. The directionality of associations for individual EDCs was inconsistent across follow-up visits. In conclusion, specific EDCs may be associated with perceived stress in Black women. This article is part of a Special Collection on Environmental Epidemiology. [ABSTRACT FROM AUTHOR]
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Database: Complementary Index
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Abstract:Persistent endocrine-disrupting chemicals (EDCs) can dysregulate the stress response. We evaluated associations between persistent EDCs and perceived stress among participants in the Study of Environment, Lifestyle, and Fibroids (n  = 1394), a prospective cohort study of Black women. Participants completed the Perceived Stress Scale 4 (PSS-4) at baseline and every 20 months through 60 months (score range: 0-16); higher scores indicate higher stress. Endocrine-disrupting chemicals, including per- and polyfluoroalkyl substances, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides, were quantified in plasma samples at baseline. We fit bayesian kernel machine regression and linear mixed-effects models to estimate associations of EDCs (as a mixture and individually) with PSS-4 scores at baseline and at each follow-up visit, respectively. Increasing percentiles of the mixture were not strongly associated with PSS-4 scores at baseline, and no interactions were observed among EDCs. Several individual EDCs (eg, perfluorodecanoic acid, PCB 118, PBDE 99) were associated with higher PSS-4 scores at baseline or follow-up, and other EDCs (eg PCB 138/158) were associated with lower PSS-4 scores at baseline or follow-up. The directionality of associations for individual EDCs was inconsistent across follow-up visits. In conclusion, specific EDCs may be associated with perceived stress in Black women. This article is part of a Special Collection on Environmental Epidemiology. [ABSTRACT FROM AUTHOR]
ISSN:00029262
DOI:10.1093/aje/kwae088