Global evolution of ferroptosis research: a comprehensive bibliometric analysis of publication trends, geographic patterns, pharmacological innovation, and translational progress from inception through 2025.
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| Titel: | Global evolution of ferroptosis research: a comprehensive bibliometric analysis of publication trends, geographic patterns, pharmacological innovation, and translational progress from inception through 2025. |
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| Autoren: | Taha MME; Health Research Centre, Jazan University, Jazan, Saudi Arabia., Abdelwahab SI; Health Research Centre, Jazan University, Jazan, Saudi Arabia. siddigroa@yahoo.com. |
| Quelle: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jan 22. Date of Electronic Publication: 2026 Jan 22. |
| Publication Model: | Ahead of Print |
| Publikationsart: | Journal Article |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin, New York, Springer Verlag. |
| Abstract: | Ferroptosis is an iron-dependent form of regulated cell death with increasing relevance to pharmacology, particularly in cancer therapy, neuroprotection, and metabolic disease modulation. Despite the rapid growth of the field, existing bibliometric studies remain fragmented, disease-specific, and largely confined to Web of Science databases, with limited coverage beyond 2023. This study presents a comprehensive dual-dataset Scopus-based bibliometric analysis of ferroptosis research (2012-2025), comprising 12,846 original articles representing the global landscape and 1797 pharmacologically enriched articles focused on therapeutic development. Using Bibliometrix, VOSviewer, and CiteSpace, the analysis evaluates publication trends, geographic distribution, collaboration networks, keyword co-occurrence, thematic evolution, and strategic mapping based on Bradford's Law and Callon's density-centrality metrics, characterizing publication dynamics, intellectual structure, translational trajectories, and pharmacological innovation patterns relevant to drug discovery. Results revealed exponential growth in output, particularly after 2020, with China contributing the largest share of publications, while Western countries demonstrated higher citation impact. Core mechanistic themes centered on GPX4, oxidative stress, and lipid peroxidation, whereas recent thematic evolution highlights increasing emphasis on immunotherapy, prognostic biomarkers, and non-oncological degenerative diseases. Pharmacological thematic mapping identified doxorubicin cardiotoxicity as a dominant motor theme, with sorafenib, network pharmacology, and ubiquitination emerging as foundational therapeutic constructs. This analysis positions ferroptosis as a mature and rapidly expanding pharmacological research domain, identifies key translational frontiers, and provides a strategic framework to guide future drug discovery and therapeutic development. (© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: There is no form of human subject involved in this manuscript; therefore, ethics approval is not required. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
| References: | Aabis M, Tiwari P, Kumar V, Singh G, Panghal A, Jena G (2025) Pentadecanoic acid attenuates thioacetamide-induced liver fibrosis by modulating oxidative stress, inflammation, and ferroptosis pathways in rat. Naunyn Schmiedebergs Arch Pharmacol 398:15287–15306. (PMID: 4031052610.1007/s00210-025-04143-6) Aalders J, Léger L, Hassannia B, Goossens V, Vanden Berghe T, van Hengel J (2024) Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis. Regen Ther 27:21–31. (PMID: 384960111094089310.1016/j.reth.2024.02.007) Abadin X, de Dios C, Zubillaga M, Ivars E, Puigròs M, Marí M, Morales A, Vizuete M, Vitorica J, Trullas R, Colell A, Roca-Agujetas V (2024) Neuroinflammation in age-related neurodegenerative diseases: role of mitochondrial oxidative stress. Antioxidants (Basel) 13(12):1440. (PMID: 3976576910.3390/antiox13121440) Abah MO, Ogenyi DO, Zhilenkova AV, Essogmo FE, Uchendu IK, Tchawe YSN, Pascal AM, Nikitina NM, Oloche OS, Pavliv M, Rusanov AS, Sanikovich VD, Pirogova YN, Bagmet LN, Moiseeva AV, Sekacheva MI (2025) Comparative transcriptomics study of curcumin and conventional therapies in translocation, clear cell, and papillary renal cell carcinoma subtypes. Int J Mol Sci 26(13):6161. Abass SA, Mohamed AA, El-Slam AHA, Yousef AM, Ayoub MK, Salah B, Abdo W, Hamid MMA (2025) Vitamin K1 attenuates acetaminophen-induced ferroptotic hepatic damage in mice via targeting keap1/Nrf2/HO-1 pathway. Naunyn Schmiedebergs Arch Pharmacol. https://doi.org/10.1007/s00210-025-04637-3. Abd El-Khalik SR, AbuoHashish NA, Nasif E, Arakeep HM, El-Anwar N, Yousef DM, Ayad NH (2025) Possible mitigating effect of nobiletin on rotenone-induced parkinsonism in male albino rat model: targeting Bmal1/Nrf2 mediated ferroptosis and restoring mitochondrial mitophagy. Neurochem Res 50:208. (PMID: 4056301810.1007/s11064-025-04438-3) Aria M, Cuccurullo C (2017) Bibliometrix: an R-tool for comprehensive science mapping analysis. J Informetr 11:959–975. (PMID: 10.1016/j.joi.2017.08.007) Badgley MA, Kremer DM, Carlo Maurer H, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Scott Seeley E, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP (2020) Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science 368(6486):85–89. (PMID: 32241947768191110.1126/science.aaw9872) Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575:688–692. (PMID: 31634900688316710.1038/s41586-019-1705-2) Cevallos C, Jarmoluk P, Sviercz F, Freiberger RN, López CAM, Delpino MV, Quarleri J (2025) Ferroptosis and mitochondrial ROS are central to SARS-CoV-2-induced hepatocyte death. Front Cell Infection Microbiology 15:1625928. (PMID: 10.3389/fcimb.2025.1625928) Chang Y, Sun Z, Xu M (2025) miR-4793–3p predicts poor prognosis and regulates ferroptosis and invasiveness of breast cancer via targeting RNF169. World J Surg Oncol 23(1):381. Chen C (2014) The citespace manual. College of Computing and Informatics 1:1–84. Choi JY, Chung J (2024) Hepatoprotective effects of an iron chelator, deferoxamine, in a mouse model of metabolic dysfunction-associated fatty liver disease. J Nutr Health 57:580–589. (PMID: 10.4163/jnh.2024.57.6.580) Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O, Gu W (2019) ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nat Cell Biol 21:579–591. (PMID: 30962574662484010.1038/s41556-019-0305-6) Deng H, Wei J, Min K, Yang H, Wang S, Xiao Z, Liu M, Zheng L, Zhou H, Chen Y, Zhu W, Li Q, Lv X (2023) Research trends in ferroptosis since the origin of the concept: a bibliometric analysis. Clin Exp Pharmacol Physiol 50:149–157. (PMID: 3630124110.1111/1440-1681.13732) Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060–1072. (PMID: 22632970336738610.1016/j.cell.2012.03.042) Dixon SJ, Patel D, Welsch M, Skouta R, Lee E, Hayano M, Thomas AG, Gleason C, Tatonetti N, Slusher BS, Stockwell BR (2014) Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. eLife 2014. 20(3):e02523. https://doi.org/10.7554/eLife.02523. Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayír H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Friedmann-Angeli JPF, Conrad M (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol 13:91–98. (PMID: 2784207010.1038/nchembio.2239) Doll S, Freitas FP, Shah R, Aldrovandi M, da Costa Silva MC, Ingold I, Grocin AG, da Xavier Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O’Donnell V, Proneth B, Popowicz GM, Pratt DA, Friedmann-Angeli JPF, Conrad M (2019) FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575:693–698. (PMID: 3163489910.1038/s41586-019-1707-0) Du L, Lv S, He D, Chen X, Liu L, Song X, Zhang J, Qiao Z, Luo Y (2025) The ferroptosis-related gene MAFG screened by machine learning is associated with the diagnosis and prognosis of sepsis. Clinical and Experimental Medicine 25(1):347. (PMID: 411714771257877610.1007/s10238-025-01880-z) Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N (2017) Nrf2-keap1 pathway promotes cell proliferation and diminishes ferroptosis. Oncogenesis 6(8):e37. (PMID: 10.1038/oncsis.2017.65) Fang X, Cai Z, Wang H, Han D, Cheng Q, Zhang P, Gao F, Yu Y, Song Z, Wu Q, An P, Huang S, Pan J, Chen HZ, Chen J, Linkermann A, Min J, Wang F (2020) Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circ Res 127:486–501. (PMID: 3234964610.1161/CIRCRESAHA.120.316509) Feng B, Guo HY, Ning Y, Zhao YY, Wang X, Cui R (2025) LPCAT3 regulates the immune infiltration and prognosis of ccRCC patients by mediating ferroptosis and endoplasmic reticulum stress. Discover Oncology 16(1):574. (PMID: 402535751200926310.1007/s12672-025-02283-y) Friedmann-Angeli JPF, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O’Donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16:1180–1191. (PMID: 2540268310.1038/ncb3064) Gao M, Monian P, Quadri N, Ramasamy R, Jiang X (2015) Glutaminolysis and transferrin regulate ferroptosis. Mol Cell 59:298–308. (PMID: 26166707450673610.1016/j.molcel.2015.06.011) Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E, Ye LF, Tyurina YY, Lin AJ, Shchepinov MS, Chan AY, Peguero-Pereira E, Fomich MA, Daniels JD, Bekish AV, Shmanai VV, Kagan VE, Mahal LK, Woerpel KA, Stockwell BR (2018) FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol 14:507–515. (PMID: 29610484589967410.1038/s41589-018-0031-6) Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z, Wu G (2018) Ferroptosis: a novel anti-tumor action for cisplatin. Cancer Res Treat 50:445–460. (PMID: 2849453410.4143/crt.2016.572) Guo SB, Liu DY, Fang XJ, Meng Y, Zhou ZZ, Li J, Li M, Luo LL, Li HL, Cai XY, Huang WJ, Tian XP (9900) Current concerns and future directions of large language model chatGPT in medicine: a machine-learning-driven global-scale bibliometric analysis. Int J Surg. https://doi.org/10.1097/JS1099.0000000000003668. Guo SB, Liu DY, Hu R, Zhou ZZ, Meng Y, Li HL, Huang WJ, Tian XP (2025) Immune-related adverse events of neoadjuvant immunotherapy in patients with perioperative cancer: a machine-learning-driven, decade-long informatics investigation. J Immunother Cancer 13(8):e011040. Huang T, Zhang J (2025) Therapeutic suppression of triple-negative breast cancer via pachymic acid-induced KIF18B inhibition and ferroptosis activation. Mol Carcinog 64:2075–2085. (PMID: 4105647810.1002/mc.70045) Jankauskas SS, Kansakar U, Sardu C, Varzideh F, Avvisato R, Wang X, Matarese A, Marfella R, Ziosi M, Gambardella J, Santulli G (2023) COVID-19 causes ferroptosis and oxidative stress in human endothelial cells. Antioxidants (Basel) 12. https://doi.org/10.3390/antiox12020326. Ji B, Yang G, Jin H, Liu X, Li H, Pan L, Lu W, Zhu H, Li Y (2023) Trends and hotspots of publications on ferroptosis: a 10 year overview. Heliyon 9:e18950. (PMID: 376003671043272310.1016/j.heliyon.2023.e18950) Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W (2015) Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520:57–62. (PMID: 25799988445592710.1038/nature14344) Kagan VE, Mao G, Qu F, Friedmann-Angeli JPF, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayír H (2017) Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol 13:81–90. (PMID: 2784206610.1038/nchembio.2238) Li G, Liang Y, Yang H, Zhang W, Xie T (2022) The research landscape of ferroptosis in cancer: a bibliometric analysis. Frontiers in Cell and Developmental Biology 10:841724. (PMID: 35693942917467510.3389/fcell.2022.841724) Li J, Wang Y, Huang J, Gong D (2024a) Knowledge mapping of ferroptosis in Parkinson’s disease: a bibliometric analysis: 2012–2023. Front Aging Neurosci 16:1433325. Li Y, Tang L, Wang F, Gao C, Yang Q, Luo L, Wei J, Tang Q, Qi M (2024) Hub genes identification and validation of ferroptosis in SARS-CoV-2 induced ARDS: perspective from transcriptome analysis. Front Immunol 15:1407924. (PMID: 391706091133550010.3389/fimmu.2024.1407924) Lin SP, Huang FY, Wu RH, Xie WJ, Chen MH, Dai SZ, Xu WT, Zheng WP, Tan GH (2025) Toxicarioside H induces ferroptosis in triple-negative breast cancer cells through Nrf2/HO-1 pathway. Discover Oncology 16(1):772. (PMID: 403725761208180710.1007/s12672-025-02333-5) Lin X, Yang H, Cai T, Yang Z, Niu S, Jia H (2025b) Polygonum multiflorum stilbene glycoside oligomers induce the ferroptosis of triple negative breast cancer cells. BMC Cancer 25(1):676. Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, de Zen F, Prókai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vandenberghe TV, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S (2014) Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A 111:16836–16841. (PMID: 25385600425013010.1073/pnas.1415518111) Liu P, Feng Y, Li H, Chen X, Wang G, Xu S, Li Y, Zhao L (2020) Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. https://doi.org/10.1186/s11658-020-00205-0. (PMID: 10.1186/s11658-020-00205-0325142697257216) Liu Y, Tang H, Xu P, Zhou X, Li S (2025) SARS-CoV-2 n protein interacts with SLC7A11 to cause ferroptosis in acute lung injury. Allergol Immunopathol (Madr) 53:23–30. (PMID: 4034211110.15586/aei.v53i3.1340) Luo J-Y, Deng Y-L, Lu S-Y, Chen S-Y, He R-Q, Qin D-Y, Chi B-T, Chen G, Yang X, Peng W (2025) Current status and future directions of ferroptosis research in breast cancer: bibliometric analysis. Interact J Med Res 14:e66286. (PMID: 400098421190437910.2196/66286) Ma X, Quan C (2025) Identification of KIF14 as a ferroptosis biomarker for predicting the prognosis and immunotherapy efficacy of bladder cancer. Discover Oncology 16(1):772. (PMID: 10.1007/s12672-025-03492-1) Miao Y-D, Quan W, Dong X, Gan J, Ji C-F, Wang J-T, Zhang F (2023) A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022. Cell Death Discov 9:129. (PMID: 370615351010575010.1038/s41420-023-01421-1) Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A, Vučković AM, Bosello-Travain V, Zaccarin M, Zennaro L, Maiorino M, Toppo S, Ursini F, Cozza G (2020) Insight into the mechanism of ferroptosis inhibition by ferrostatin-1. Redox Biol 28:101328. Mohammadbeygi A, Brujeni GN, Eftekhari Z, Kazerouni NP (2025) Prescription FINO2 and pirfenidone supported in reducing fibrosis in mouse breast tumor tissue by targeting SLC7A11 and HMOX1. Curr Top Med Chem. https://doi.org/10.2174/0115680266353809250526084207. Najmi A, Rashidi TH, Abbasi A, Travis Waller S (2017) Reviewing the transport domain: an evolutionary bibliometrics and network analysis. Scientometrics 110:843–865. (PMID: 10.1007/s11192-016-2171-3) Nhung DT, Yousif OEA, Kwon B (2025) Sorafenib induces ferroptosis in human renal cell carcinoma cells through CCAT/enhancer-binding protein homologous protein. Biochem Biophys Rep 43:102143. (PMID: 4068850112272583) Pan J, Zhang Y, Zhao B, Shao W, Chen X (2025) Current perspectives and trend of ferroptosis in head and neck cancer: a bibliometric analysis. Frontiers in Oral Health 6:1601962. (PMID: 408607931237073810.3389/froh.2025.1601962) Peleman C, Van Coillie S, Ligthart S, Choi SM, De Waele J, Depuydt P, Benoit D, Schaubroeck H, Francque SM, Dams K, Jacobs R, Robert D, Roelandt R, Seurinck R, Saeys Y, Rajapurkar M, Jorens PG, Hoste E, Vanden Berghe T (2023) Ferroptosis and pyroptosis signatures in critical COVID-19 patients. Cell Death Differ 30:2066–2077. (PMID: 375828641048295810.1038/s41418-023-01204-2) Peng C, Yan F, Xu M, Zhao Y, Sun J (2025) WGCNA and single-cell analysis reveal ferroptosis-related gene signatures for hepatocellular carcinoma prognosis and therapy. Discover Oncology 16(1):1483. (PMID: 407678981232886610.1007/s12672-025-03335-z) Song W, Sun P, Zhao T, Zang Y, Dong P, Tang Q, Chen W, Chen W, Wang Z, Zhang Q, Wang Y, Yin C, Yu M (2025) Unveiling the therapeutic potential of ferroptosis in lung cancer: a comprehensive bibliometric analysis and future therapeutic insights. Discov Oncol 16:508. (PMID: 402085191198570610.1007/s12672-025-02234-7) Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D (2018) AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system Xc – activity. Curr Biol 28:2388-2399.e2385. (PMID: 30057310608125110.1016/j.cub.2018.05.094) Sui X, Zhang R, Liu S, Duan T, Zhai L, Zhang M, Han X, Xiang Y, Huang X, Lin H, Xie T (2018) RSL3 drives ferroptosis through GPX4 inactivation and ros production in colorectal cancer. Front Pharmacol 9:1371. Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, Tang D (2016) Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology 63:173–184. (PMID: 2640364510.1002/hep.28251) Tan L, He G, Shen C, He S, Chen Y, Guo X (2025) Construction of a ferroptosis-based prediction model for the prognosis of MYCN-amplified neuroblastoma and screening and verification of target sites. Hereditas. https://doi.org/10.1186/s41065-025-00413-8. (PMID: 10.1186/s41065-025-00413-84096247612357469) Van Eck N, Waltman L (2010) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 84:523–538. (PMID: 2058538010.1007/s11192-009-0146-3) Wan Liah WN, Zulnaidi H, Kenayathulla HB (2025) Revealing breakthrough trends in teacher effectiveness research: a comprehensive bibliometric analysis with Lotka’s and Price’s law. Int J Educ Manag 39:338–360. Wang H, An P, Xie E, Wu Q, Fang X, Gao H, Zhang Z, Li Y, Wang X, Zhang J, Li G, Yang L, Liu W, Min J, Wang F (2017) Characterization of ferroptosis in murine models of hemochromatosis. Hepatology 66:449–465. (PMID: 2819534710.1002/hep.29117) Wang L, Liu Y, Du T, Yang H, Lei L, Guo M, Ding HF, Zhang J, Wang H, Chen X, Yan C (2020) ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–. Cell Death Differ 27:662–675. (PMID: 3127329910.1038/s41418-019-0380-z) Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieślik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W (2019) CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature 569:270–274. (PMID: 31043744653391710.1038/s41586-019-1170-y) Wang X, Song D, Zhou Z, Jiang Z, Zhang N, Zhang H, Xia D (2023) A comprehensive and visualized analysis of relationship between ferroptosis and tumor using bibliometrics and bioinformatics. Am J Cancer Res 13:6190–6209. (PMID: 3818704110767352) Wang X, Zhang W, Liang K, Wang Y, Zhang J, Wang J, Li A, Yun Y, Liu H, Sun Y (2025) Identification of m6 A-regulated ferroptosis biomarkers for prognosis in laryngeal cancer. BMC Cancer. https://doi.org/10.1186/s12885-025-14134-8. (PMID: 10.1186/s12885-025-14134-84146995112817499) Wang Z, Zhang H, Wang L, Ma Z, Cui Ya, Fu H, Yu C (2023b) Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to cancer immunity and immunotherapy. Front Oncol 13:1183405. Wei T, Qin Y, Lin X, Wang X, Chen S, Chen X, Yan N, Wei X, Zhang Z, Wei B (2025) Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy. Front Physiol 16:1516466. Wen Q, Liu J, Kang R, Zhou B, Tang D (2019) The release and activity of HMGB1 in ferroptosis. Biochem Biophys Res Commun 510:278–283. (PMID: 3068653410.1016/j.bbrc.2019.01.090) Wu H, Cheng K, Li C (2023) Ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer: a comparative bibliometric analysis. Cell Death Discov 9:238. (PMID: 374298611033321210.1038/s41420-023-01542-7) Wu H, Wang Y, Tong L, Yan H, Sun Z (2021) Global research trends of ferroptosis: a rapidly evolving field with enormous potential. Front Cell Dev Biol 9:646311. Xia S, Li L, Shi Z, Sun N, He Y (2025) Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies. Frontiers in Immunology 16:1604652. (PMID: 405470141217890210.3389/fimmu.2025.1604652) Xie L, Zhang Y, Niu X, Kang Y, Li W, Yao J (2025) A comprehensive bibliometric analysis of ferroptosis in tumor resistance: development and emerging trends. Front Immunol 16:1580222. Xiong L, Gao X, Wang L, Luo L, Su J, Wang Y, Shen Y (2025) The influence of ferroptosis-associated gene HSPA5 on the prognosis and immune evasion of lung adenocarcinoma. Discov Oncol. https://doi.org/10.1007/s12672-025-03629-2. (PMID: 10.1007/s12672-025-03629-24136658212799877) Yang L, An X, Yang S, Lin X, Chen Z, Xue Q, Chen X, Wang Y, Yan D, Chen S, Fan Y, Tang D, Yu W, Liu J, Chen X (2025) The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein. Cell Death Dis 16(1):564. Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci U S A 113:E4966–E4975. (PMID: 27506793500326110.1073/pnas.1603244113) Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156:317–331. (PMID: 24439385407641410.1016/j.cell.2013.12.010) Yao F, Guo F, Sun C, Wang E, Wang H, Li N (2025a) Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer. Front Genet 15:1449491. Yao X, Shen X, Fan Y, Wang H (2025) TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer. NPJ Breast Cancer. https://doi.org/10.1038/s41523-025-00779-y. (PMID: 10.1038/s41523-025-00779-y4103423212488878) Yehia A, Abulseoud OA (2024) Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration. Mol Neurodegener 19:36. (PMID: 386418471103198010.1186/s13024-024-00728-6) Yu M, Cui W, Hu Y, Song W, Wang Z, Chen W, Ji X, Tang C, Lv J, Hao T (2025) Ferroptosis research based on bibliometric and visual analysis: mechanism exploration and clinical application prospects in gastric cancer, prostate cancer, leukemia, and brain tumors. Front Med (Lausanne) 12:1640497. (PMID: 4121086510.3389/fmed.2025.1640497) Yu W, Jing Z, Tang J, Chen J (2025b) A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma. Discov Oncol 16. https://doi.org/10.1007/s12672-025-01947-z. Yuan H, Hua Z, Zhang H, Xu D (2025) Ferroptosis and ovarian cancer: a bibliometric study and visualization analysis. Discover Oncol 16:1572. (PMID: 10.1007/s12672-025-03332-2) Yuan H, Li X, Zhang X, Kang R, Tang D (2016) Identification of ACSL4 as a biomarker and contributor of ferroptosis. Biochem Biophys Res Commun 478:1338–1343. (PMID: 2756572610.1016/j.bbrc.2016.08.124) Yuan J, Liu C, Jiang C, Liu N, Yang Z, Xing H (2025) RSL3 induces ferroptosis by activating the NF-κB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel. Sci Rep. https://doi.org/10.1038/s41598-025-85774-w. (PMID: 10.1038/s41598-025-85774-w4146983912808313) Zeng LR, Zhu GH, Mei HB, Yang G (2025) Signature of immune infiltration‑related ferroptosis genes to predict the prognosis of patients with osteosarcoma. Oncol Lett. https://doi.org/10.3892/ol.2025.15308. (PMID: 10.3892/ol.2025.153084138397412690628) Zeng Y, Xu Z, Huang J, Yi Q, Chen X, Wang J, Du Z, Tian J, Yan Y (2025) THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer. Breast Cancer Res. https://doi.org/10.1186/s13058-025-02078-7. (PMID: 10.1186/s13058-025-02078-74128706512750819) Zhang J, Song L, Xu L, Fan Y, Wang T, Tian W, Ju J, Xu H (2021) Knowledge domain and emerging trends in ferroptosis research: a bibliometric and knowledge-map analysis. Frontiers in Oncology 11:686726. (PMID: 34150654820949510.3389/fonc.2021.686726) Zhang W, Gu J, Chen Y, Jiang G, Gonzalez-Rivas D, Ma M, Chen C (2025) Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis. Front Immunol 16:1563108. Zhang Y, Tan H, Daniels JD, Zandkarimi F, Liu H, Brown LM, Uchida K, O’Connor OA, Stockwell BR (2019) Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model. Cell Chem Biol 26:623–633.e629. (PMID: 30799221652507110.1016/j.chembiol.2019.01.008) Zheng X, Diao M, Tong S, Yang S, Lin J, Zhuo S, Wang T, Dai J, Chen S, Wang K (2025) Global research landscape and hotspots for ferroptosis in glioma: a comprehensive bibliometric and visual analysis. Heliyon 11:e42242. (PMID: 399314741180850910.1016/j.heliyon.2025.e42242) Zhou H, Mao Y, Zhou Z (2024) Charting the course of ferroptosis research in lung cancer: insights from a bibliometric analysis. Heliyon 10:e24810. (PMID: 383125751083536010.1016/j.heliyon.2024.e24810) |
| Contributed Indexing: | Keywords: Bibliometric analysis; Ferroptosis; GPX4; Lipid peroxidation; Programmed cell death |
| Entry Date(s): | Date Created: 20260122 Latest Revision: 20260122 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s00210-026-05021-5 |
| PMID: | 41569313 |
| Datenbank: | MEDLINE |
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