High-performance hexagonal cavity-based plasmonic MIM waveguide biosensor for sensitive and label-free detection of carcinoembryonic antigen (CEA).
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| Titel: | High-performance hexagonal cavity-based plasmonic MIM waveguide biosensor for sensitive and label-free detection of carcinoembryonic antigen (CEA). |
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| Autoren: | Bahador H; Department of Electrical and Computer Engineering, University of Mohaghegh Ardabil, Ardabil, Iran. hamid.bahador@uma.ac.ir., Izadiyar H; Department of Electrical and Computer Engineering, University of Mohaghegh Ardabil, Ardabil, Iran., Abdoli Z; Department of Electrical and Computer Engineering, University of Mohaghegh Ardabil, Ardabil, Iran., Nilghaz A; Drug Delivery, Disposition, and Dynamics, Monash University, Parkville, VIC, 3052, Australia. |
| Quelle: | Scientific reports [Sci Rep] 2025 Dec 04. Date of Electronic Publication: 2025 Dec 04. |
| Publication Model: | Ahead of Print |
| Publikationsart: | Journal Article |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Abstract: | In this research, a plasmonic metal-insulator-metal (MIM) biosensor is proposed and numerically analyzed for label-free and highly sensitive refractive index detection. The design incorporates a hybrid configuration consisting of a hexagonal resonant cavity coupled with a narrow rectangular slit along its lower boundary. This particular arrangement, which has not been previously reported, enables the excitation of two distinct resonance modes that contribute to improved spectral resolution and sensing precision relative to conventional MIM structures. Finite-difference time-domain (FDTD) simulations were employed to investigate the optical response and optimize the geometrical parameters of the device. The optimized sensor demonstrates strong electromagnetic field confinement, achieving a sensitivity of 770.27 nm/RIU and a figure of merit (FoM) of 160.47, both of which surpass values reported in related studies. Owing to its compact geometry and compatibility with nanoimprint lithography, the proposed design can be fabricated with high practicality. These findings suggest that the device offers an efficient and scalable platform for real-time, label-free detection of carcinoembryonic antigen (CEA) and other biomarkers relevant to early-stage disease diagnostics. (© 2025. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: MIM biosensor; Plasmonic waveguide biosensor; Sensitivity; Surface plasmon polariton |
| Entry Date(s): | Date Created: 20251204 Latest Revision: 20251204 |
| Update Code: | 20251205 |
| DOI: | 10.1038/s41598-025-30910-9 |
| PMID: | 41345439 |
| Datenbank: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | In this research, a plasmonic metal-insulator-metal (MIM) biosensor is proposed and numerically analyzed for label-free and highly sensitive refractive index detection. The design incorporates a hybrid configuration consisting of a hexagonal resonant cavity coupled with a narrow rectangular slit along its lower boundary. This particular arrangement, which has not been previously reported, enables the excitation of two distinct resonance modes that contribute to improved spectral resolution and sensing precision relative to conventional MIM structures. Finite-difference time-domain (FDTD) simulations were employed to investigate the optical response and optimize the geometrical parameters of the device. The optimized sensor demonstrates strong electromagnetic field confinement, achieving a sensitivity of 770.27 nm/RIU and a figure of merit (FoM) of 160.47, both of which surpass values reported in related studies. Owing to its compact geometry and compatibility with nanoimprint lithography, the proposed design can be fabricated with high practicality. These findings suggest that the device offers an efficient and scalable platform for real-time, label-free detection of carcinoembryonic antigen (CEA) and other biomarkers relevant to early-stage disease diagnostics.<br /> (© 2025. The Author(s).) |
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| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-025-30910-9 |