A randomized clinical trial of multi-level intervention to improve colorectal cancer screening rates at multiple federally qualified health care centers in New York City.
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| Názov: | A randomized clinical trial of multi-level intervention to improve colorectal cancer screening rates at multiple federally qualified health care centers in New York City. |
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| Autori: | Shaukat A; Division of Gastroenterology (AS. GF, AA, SM), Department of Medicine, NYU Grossman School of Medicine, New York, USA; Department of Population Health (AS, JH, YZ, ES, JR, DM), NYU Grossman School of Medicine, New York, USA. Electronic address: Aasma.shaukat@nyulangone.org., Hu J; Department of Population Health (AS, JH, YZ, ES, JR, DM), NYU Grossman School of Medicine, New York, USA., Zhao Y; Department of Population Health (AS, JH, YZ, ES, JR, DM), NYU Grossman School of Medicine, New York, USA., Faulx G; Division of Gastroenterology (AS. GF, AA, SM), Department of Medicine, NYU Grossman School of Medicine, New York, USA., Augustin A; Division of Gastroenterology (AS. GF, AA, SM), Department of Medicine, NYU Grossman School of Medicine, New York, USA., Murphy S; Division of Gastroenterology (AS. GF, AA, SM), Department of Medicine, NYU Grossman School of Medicine, New York, USA., Stevens E; Department of Population Health (AS, JH, YZ, ES, JR, DM), NYU Grossman School of Medicine, New York, USA., Ravenell J; Department of Population Health (AS, JH, YZ, ES, JR, DM), NYU Grossman School of Medicine, New York, USA., Makarov D; Department of Population Health (AS, JH, YZ, ES, JR, DM), NYU Grossman School of Medicine, New York, USA., Napolitano D; Department of Population Health (AS, JH, YZ, ES, JR, DM), NYU Grossman School of Medicine, New York, USA; Community Health Centers of New York (DN), New York, USA. |
| Zdroj: | Contemporary clinical trials [Contemp Clin Trials] 2025 Dec; Vol. 159, pp. 108115. Date of Electronic Publication: 2025 Oct 25. |
| Spôsob vydávania: | Journal Article; Clinical Trial Protocol |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Elsevier Country of Publication: United States NLM ID: 101242342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2030 (Electronic) Linking ISSN: 15517144 NLM ISO Abbreviation: Contemp Clin Trials Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, N.Y. : Elsevier, c2005- |
| Výrazy zo slovníka MeSH: | Colorectal Neoplasms*/diagnosis , Early Detection of Cancer*/methods , Early Detection of Cancer*/statistics & numerical data, Humans ; New York City ; Middle Aged ; Aged ; Patient Navigation/organization & administration ; Cost-Benefit Analysis ; Occult Blood ; Female ; Male ; Colonoscopy/statistics & numerical data ; Randomized Controlled Trials as Topic ; Reminder Systems ; Poverty ; Patient Education as Topic |
| Abstrakt: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Introduction: Colorectal cancer (CRC) screening rates among patients receiving care at multiple federally qualified health care centers (FQHCs) in New York city are low. Proactive outreach through mailed fecal immunochemical tests (FIT), reminders and navigation are evidence based interventions to improve CRC screening rates but remain untested in this study population. Objective: To evaluate the effectiveness, implementation, and cost-effectiveness of a multilevel proactive outreach strategy to improve CRC screening rates among underserved adults in Brooklyn, New York. Methods: This is a randomized controlled trial across five FQHCs serving predominantly Black and low-income populations. Adults aged 45-75 who are overdue for CRC screening are randomized to usual care or a multi-level proactive intervention. The intervention includes mailed education and FIT kits, patient navigation, and support for colonoscopy scheduling and follow-up. The primary outcome is CRC screening completion (FIT or colonoscopy) within six months. Secondary outcomes include colonoscopy follow-up after a positive FIT, implementation barriers and facilitators, and cost-effectiveness. Results: A total of 1379 participants have been enrolled through May 2025. Discussion: This trial addresses a critical gap in CRC prevention by testing a scalable, multilevel outreach model tailored to underserved populations. Findings will inform future strategies to enhance screening rates while reducing screening disparities through sustainable FQHC-based programs. (Copyright © 2025. Published by Elsevier Inc.) |
| Contributed Indexing: | Keywords: Colorectal cancer screening; Evidence-based interventions; Fecal immunochemical testing; Health Disparities; Proactive intervention |
| Entry Date(s): | Date Created: 20251201 Date Completed: 20251201 Latest Revision: 20251201 |
| Update Code: | 20251202 |
| DOI: | 10.1016/j.cct.2025.108115 |
| PMID: | 41326264 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />Introduction: Colorectal cancer (CRC) screening rates among patients receiving care at multiple federally qualified health care centers (FQHCs) in New York city are low. Proactive outreach through mailed fecal immunochemical tests (FIT), reminders and navigation are evidence based interventions to improve CRC screening rates but remain untested in this study population.<br />Objective: To evaluate the effectiveness, implementation, and cost-effectiveness of a multilevel proactive outreach strategy to improve CRC screening rates among underserved adults in Brooklyn, New York.<br />Methods: This is a randomized controlled trial across five FQHCs serving predominantly Black and low-income populations. Adults aged 45-75 who are overdue for CRC screening are randomized to usual care or a multi-level proactive intervention. The intervention includes mailed education and FIT kits, patient navigation, and support for colonoscopy scheduling and follow-up. The primary outcome is CRC screening completion (FIT or colonoscopy) within six months. Secondary outcomes include colonoscopy follow-up after a positive FIT, implementation barriers and facilitators, and cost-effectiveness.<br />Results: A total of 1379 participants have been enrolled through May 2025.<br />Discussion: This trial addresses a critical gap in CRC prevention by testing a scalable, multilevel outreach model tailored to underserved populations. Findings will inform future strategies to enhance screening rates while reducing screening disparities through sustainable FQHC-based programs.<br /> (Copyright © 2025. Published by Elsevier Inc.) |
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| ISSN: | 1559-2030 |
| DOI: | 10.1016/j.cct.2025.108115 |