The middle frontal gyrus as a neural mediator between family relationships and internet addiction among adolescents with internet gaming disorder: a cross-sectional study.
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| Název: | The middle frontal gyrus as a neural mediator between family relationships and internet addiction among adolescents with internet gaming disorder: a cross-sectional study. |
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| Autoři: | Zhang Y; The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou, Henan, China., Li Y; The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou, Henan, China., Zhang H; The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou, Henan, China., Zhao T; Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Li Y; Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Wu J; Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Wang R; Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Lv Q; Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Lang Y; Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. ly150107@163.com. |
| Zdroj: | BMC psychology [BMC Psychol] 2025 Nov 14; Vol. 13 (1), pp. 1263. Date of Electronic Publication: 2025 Nov 14. |
| Způsob vydávání: | Journal Article |
| Jazyk: | English |
| Informace o časopise: | Publisher: BioMed Central Country of Publication: England NLM ID: 101627676 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7283 (Electronic) Linking ISSN: 20507283 NLM ISO Abbreviation: BMC Psychol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2013]- |
| Výrazy ze slovníku MeSH: | Internet Addiction Disorder*/physiopathology , Internet Addiction Disorder*/diagnostic imaging , Internet Addiction Disorder*/psychology , Family Relations* , Prefrontal Cortex*/physiopathology , Prefrontal Cortex*/diagnostic imaging , Behavior, Addictive*/physiopathology, Humans ; Adolescent ; Male ; Cross-Sectional Studies ; Female ; Child ; Magnetic Resonance Imaging ; Internet |
| Abstrakt: | Competing Interests: Declarations. Ethics approval and consent to participate: The study protocol and study documents were approved by the local ethics committee of the First Affiliated Hospital of Zhengzhou University (reference no. 2022-KY-0438-002). Written informed consent was obtained by all participants. The study was carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Background: Previous studies have shown that family relationships are closely related to internet gaming disorder (IGD) in adolescents. There are also neurological mechanisms that correlate spontaneous brain activity with adolescent family relationships and IGD. Therefore, this study explores the mediating role of spontaneous brain activity between family relationships and IGD in adolescents. Methods: This study used a cross-sectional design. It recruited 52 IGD adolescents as the IGD group and 51 normal adolescents as the healthy control (HC) group. The study included adolescents aged 12-18 years, with a male-to-female ratio of 45:7 in the IGD group and 41:10 in the HC group. The diagnosis of IGD was established based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria. The Young Internet Addiction Scale (YIAS) was used to assess the severity of internet addiction among adolescents, and the Chinese version of the Family Environment Scale (FES-CV) was used to evaluate family relationships. Resting-state functional MRI was utilized to assess adolescents' spontaneous brain activity, specifically measuring the mean amplitude of low-frequency fluctuation (mALFF) and functional connectivity (FC). MRI data were collected using a Siemens Magnetom Prisma 3.0T MRI scanner. The specific scan sequence and parameters are as follows: BOLD sequence, repetition time (TR) = 1000 ms, echo time (TE) = 30 ms, flip angle = 70°, slice thickness = 2.2 mm, number of slices = 52, matrix size = 64 × 64, voxel size = 3 mm × 3 mm × 3 mm, scan duration = 360 s. The steps of data preprocessing included data format conversion, exclusion of time points, slice timing correction, head motion correction, spatial normalization, removal of linear drift, regression of covariates, band-pass filtering, and data cleaning. Statistical analysis was conducted using SPSS 22.0. Gaussian random field (GRF) correction was applied in the DPABI toolbox, with voxel-level p < 0.005 and cluster-level p < 0.05 indicating statistical significance. Pearson correlation was employed to analyze the relationships between various scales and between these scales and brain spontaneous activity. Mediation analysis was performed using the SPSS Process program. Results: (1) Compared to the HC group, the IGD group had significantly higher YIAS scores (t = 21.571, P < 0.05). For the FES-CV scores, the IGD group scored higher in conflict (t = 4.228, P < 0.05) and lower in cohesion (t=-3.768, P < 0.05), with statistically significant differences. (2) Pearson correlation analysis revealed a negative correlation between cohesion in family relationships and middle frontal gyrus (MFG) (r = - 0.443, p < 0.01), a negative correlation between cohesion and internet addiction (r = - 0.474, p < 0.01), and a positive correlation between internet addiction and MFG (r = 0.557, p < 0.01) in the IGD group. The MFG mediated the relationship between family relationships and internet addiction, with a mediation effect value of -0.183 (95% CI=-0.403 ~ -0.037), accounting for 38.77% of the total effect (-0.183/-0.472). (3) In the IGD group, the FC value from the MFG to the right insula was positively correlated with conflict in family relationships (r = 0.349, P < 0.05). Conclusion: Family relationships are related to internet addiction in adolescents, and the MFG mediates this relationship. Additionally, the FC value from the MFG to the right insula in the IGD group is positively correlated with conflict. This suggests that the MFG may serve as a neurobiological marker through which family relationships influence IGD development in adolescents. (© 2025. The Author(s).) |
| References: | Annu Rev Psychol. 2015 Jan 3;66:711-31. (PMID: 25148852) Philos Trans R Soc Lond B Biol Sci. 2024 Dec 2;379(1915):20230090. (PMID: 39428882) J Neurosci. 2013 Nov 13;33(46):18109-24. (PMID: 24227721) Neurosci Biobehav Rev. 2019 Sep;104:1-10. (PMID: 31247240) J Behav Addict. 2020 Jan 20;9(1):93-104. (PMID: 31957460) Ind Psychiatry J. 2024 Jan-Jun;33(1):81-87. (PMID: 38853819) Psychiatry Res. 2012 May 31;202(2):126-31. (PMID: 22698763) Scand J Psychol. 2018 Oct;59(5):524-531. (PMID: 30004118) Neuroimage. 2016 Jan 1;124(Pt A):989-996. (PMID: 26434803) Soc Cogn Affect Neurosci. 2021 Mar 5;16(3):268-279. (PMID: 33227135) Dev Cogn Neurosci. 2014 Apr;8:7-17. (PMID: 24269113) Psychiatry Clin Psychopharmacol. 2022 Dec 01;32(4):344-350. (PMID: 38764878) BMC Psychiatry. 2024 May 30;24(1):410. (PMID: 38816793) J Epidemiol. 2023 Jul 5;33(7):335-341. (PMID: 34744101) Fam Process. 1990 Jun;29(2):199-208; discussion 209-11. (PMID: 2373215) Int J Environ Res Public Health. 2019 Nov 21;16(23):. (PMID: 31766527) Child Dev. 2019 Mar;90(2):593-609. (PMID: 28800148) J Behav Addict. 2023 Aug 30;12(3):758-774. (PMID: 37651282) Psychol Health Med. 2024 Oct;29(9):1602-1618. (PMID: 38770920) J Behav Addict. 2019 Dec 1;8(4):649-663. (PMID: 31786936) Int J Environ Res Public Health. 2022 Mar 03;19(5):. (PMID: 35270644) J Youth Adolesc. 2023 Jun;52(6):1272-1286. (PMID: 36773189) J Pediatr Psychol. 2013 Aug;38(7):794-807. (PMID: 23671059) Child Dev. 2011 Nov-Dec;82(6):1970-84. (PMID: 22026915) Child Psychiatry Hum Dev. 2024 Aug;55(4):1063-1072. (PMID: 36441375) Curr Psychol. 2022 Jun 6;:1-9. (PMID: 35693840) Addict Behav. 2020 Jul;106:106385. (PMID: 32187574) Dev Psychol. 2017 Jan;53(1):149-159. (PMID: 28026194) Psychol Med. 2024 Feb;54(3):473-487. (PMID: 38047402) Neurosci Biobehav Rev. 2016 Dec;71:252-266. (PMID: 27590829) Psychiatry Res. 2017 Sep;255:104-110. (PMID: 28535475) Neuroimage. 2018 Jun;173:298-310. (PMID: 29486324) J Psychiatr Res. 2022 Oct;154:35-43. (PMID: 35926424) Psychol Sci. 2015 May;26(5):583-92. (PMID: 25810453) Sci Rep. 2020 Jun 19;10(1):9951. (PMID: 32561779) Dev Med Child Neurol. 2018 Jul;60(7):645-659. (PMID: 29633243) Clin Psychol Psychother. 2020 Mar;27(2):203-213. (PMID: 31881100) Gen Hosp Psychiatry. 2014 Mar-Apr;36(2):203-7. (PMID: 24262601) Front Psychiatry. 2021 Jan 15;11:618319. (PMID: 33519558) Neuroimage. 2014 Oct 1;99:180-90. (PMID: 24862074) J Youth Adolesc. 2019 Jan;48(1):43-55. (PMID: 30178385) J Behav Addict. 2021 Mar 10;10(1):123-134. (PMID: 33704084) Arch Psychiatr Nurs. 2024 Dec;53:165-170. (PMID: 39615930) J Child Psychol Psychiatry. 2011 Apr;52(4):409-28. (PMID: 20626527) Front Neuroanat. 2022 Nov 24;16:1028546. (PMID: 36506872) J Clin Med. 2022 Feb 16;11(4):. (PMID: 35207293) |
| Contributed Indexing: | Keywords: Adolescents; Family relationships; Internet gaming disorder; Mediating effect; Middle frontal gyrus |
| Entry Date(s): | Date Created: 20251114 Date Completed: 20251115 Latest Revision: 20251117 |
| Update Code: | 20251117 |
| PubMed Central ID: | PMC12619348 |
| DOI: | 10.1186/s40359-025-03611-1 |
| PMID: | 41239403 |
| Databáze: | MEDLINE |
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