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Node role of wild boars in virus circulation among wildlife and domestic animals.

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Titel: Node role of wild boars in virus circulation among wildlife and domestic animals.
Autoren: Tu Z; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin Province, China., Sun H; Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang, Liaoning Province, China., Wang T; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin Province, China., Liu Y; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin Province, China., Xu Y; Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang, Liaoning Province, China., Peng P; Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang, Liaoning Province, China., Qin S; Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang, Liaoning Province, China., Tu C; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin Province, China. changchun_tu@hotmail.com.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou, Jiangsu Province, China. changchun_tu@hotmail.com., He B; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin Province, China. heb-001001@163.com.
Quelle: Nature communications [Nat Commun] 2025 Oct 08; Vol. 16 (1), pp. 8938. Date of Electronic Publication: 2025 Oct 08.
Publikationsart: Journal Article
Sprache: English
Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Imprint Name(s): Original Publication: [London] : Nature Pub. Group
MeSH-Schlagworte: Sus scrofa*/virology , Animals, Wild*/virology , Animals, Domestic*/virology , Viruses*/genetics , Viruses*/classification , Viruses*/isolation & purification , Swine Diseases*/virology, Animals ; Swine/virology ; China/epidemiology ; Disease Reservoirs/virology ; Virome/genetics ; Humans ; Zoonoses/virology ; Phylogeny
Abstract: Competing Interests: Competing interests: The authors declare no competing interests.
Wild boars are considered pest animals in most of their distribution ranges, but their role as virus reservoirs has long been overlooked, with the circulation dynamics of their viruses rarely investigated. Here we prepared a data set, that is, BrCN-Virome, of 9281 viral metagenomes by pan-viromic analyses of 2535 organ and 274 blood samples from 466 healthy and 50 dead wild boars across 127 locations in 26 provincial regions of China. Compared to domestic pigs, BrCN-Virome shows different viromic composition, with a great expansion in the DNA virus diversity. Some wild boar viruses are traced to humans, domestic animals, wildlife, and arthropods, with several evidently or potentially related to epizootics or zoonoses. Pig pathogens spread widely in wild boars and are responsible for a substantial portion of wild boar mortality, with occurrences of co-infection with multiple African swine fever viruses. These results indicate that wild boars are a node animal connecting different animal taxa in the virus circulation network, and that their viruses not only pose a major threat to the pig industry but also challenge wildlife conservation and public health, highlighting the need for routine surveillance of wild boar viruses and active control of the wild boar population.
(© 2025. The Author(s).)
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Entry Date(s): Date Created: 20251008 Date Completed: 20251008 Latest Revision: 20251011
Update Code: 20251011
PubMed Central ID: PMC12508043
DOI: 10.1038/s41467-025-64019-4
PMID: 41062486
Datenbank: MEDLINE
Beschreibung
Abstract:Competing Interests: Competing interests: The authors declare no competing interests.<br />Wild boars are considered pest animals in most of their distribution ranges, but their role as virus reservoirs has long been overlooked, with the circulation dynamics of their viruses rarely investigated. Here we prepared a data set, that is, BrCN-Virome, of 9281 viral metagenomes by pan-viromic analyses of 2535 organ and 274 blood samples from 466 healthy and 50 dead wild boars across 127 locations in 26 provincial regions of China. Compared to domestic pigs, BrCN-Virome shows different viromic composition, with a great expansion in the DNA virus diversity. Some wild boar viruses are traced to humans, domestic animals, wildlife, and arthropods, with several evidently or potentially related to epizootics or zoonoses. Pig pathogens spread widely in wild boars and are responsible for a substantial portion of wild boar mortality, with occurrences of co-infection with multiple African swine fever viruses. These results indicate that wild boars are a node animal connecting different animal taxa in the virus circulation network, and that their viruses not only pose a major threat to the pig industry but also challenge wildlife conservation and public health, highlighting the need for routine surveillance of wild boar viruses and active control of the wild boar population.<br /> (© 2025. The Author(s).)
ISSN:2041-1723
DOI:10.1038/s41467-025-64019-4