Zobrazit v EDS

Identification of new coumarin-cinnamic acid hybrid FtsZ inhibitors as potential bactericides for enhancing the yield and quality of rice.

Uloženo v:
Podrobná bibliografie
Název: Identification of new coumarin-cinnamic acid hybrid FtsZ inhibitors as potential bactericides for enhancing the yield and quality of rice.
Autoři: Zhang L; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China., Ma SY; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China., Chen W; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China., Yang LL; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China., Ding Y; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China., Zhou X; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China. Electronic address: xiangzhou@gzu.edu.cn., Liu LW; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China., Wu ZB; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China., Yang S; State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China. Electronic address: syang@gzu.edu.cn.
Zdroj: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 3), pp. 146505. Date of Electronic Publication: 2025 Sep 23.
Způsob vydávání: Journal Article
Jazyk: English
Informace o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
Imprint Name(s): Publication: Barking : Elsevier Applied Science Publishers
Original Publication: Barking, Eng., Applied Science Publishers.
Výrazy ze slovníku MeSH: Oryza*/microbiology , Oryza*/growth & development , Oryza*/chemistry , Oryza*/drug effects , Bacterial Proteins*/antagonists & inhibitors , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Coumarins*/chemistry , Coumarins*/pharmacology , Cinnamates*/chemistry , Cinnamates*/pharmacology, Xanthomonas/drug effects ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Seeds/growth & development ; Seeds/microbiology ; Seeds/drug effects ; Seeds/chemistry ; Molecular Structure ; Cytoskeletal Proteins
Abstrakt: Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Owing to the prevalence of cereal crop bacterial diseases worldwide, ensuring the yield and quality of rice and its seeds remains a significant challenge. To develop effective control strategies, we designed 32 new coumarin-cinnamic acid hybrids using the natural product hybridization strategy. Notably, compound 11e demonstrated significant antibacterial efficacy against rice bacteria Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola, with EC 50 of 0.053-0.069 μmol·L -1 , and exhibited excellent in vivo control efficiency. The mechanistic investigation suggested that compound 11e might bind to the BP2 pocket of XooFtsZ, inducing conformational changes that inhibit its GTPase activity (IC 50 : 173.0 μmol·L -1 ) and disrupted protofilament assembly, ultimately leading to bacterial death. Compound 11e exhibited low toxicity and satisfactory drug-likeness properties. Overall, this study indicates that compound 11e as a potent FtsZ inhibitor, highlighting its potential application as a novel bactericide candidate for enhancing the yield and quality of rice and its seeds.
(Copyright © 2025 Elsevier Ltd. All rights reserved.)
Contributed Indexing: Keywords: Antibacterial activity; Cinnamic acid; Coumarin; FtsZ; Molecular hybridization
Substance Nomenclature: 0 (Bacterial Proteins)
0 (Anti-Bacterial Agents)
0 (Coumarins)
0 (Cinnamates)
140-10-3 (cinnamic acid)
A4VZ22K1WT (coumarin)
0 (FtsZ protein, Bacteria)
0 (Cytoskeletal Proteins)
SCR Organism: Xanthomonas oryzae
Entry Date(s): Date Created: 20250928 Date Completed: 20251118 Latest Revision: 20251118
Update Code: 20251118
DOI: 10.1016/j.foodchem.2025.146505
PMID: 41016161
Databáze: MEDLINE
Popis
Abstrakt:Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />Owing to the prevalence of cereal crop bacterial diseases worldwide, ensuring the yield and quality of rice and its seeds remains a significant challenge. To develop effective control strategies, we designed 32 new coumarin-cinnamic acid hybrids using the natural product hybridization strategy. Notably, compound 11e demonstrated significant antibacterial efficacy against rice bacteria Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola, with EC <subscript>50</subscript> of 0.053-0.069 μmol·L <sup>-1</sup> , and exhibited excellent in vivo control efficiency. The mechanistic investigation suggested that compound 11e might bind to the BP2 pocket of XooFtsZ, inducing conformational changes that inhibit its GTPase activity (IC <subscript>50</subscript> : 173.0 μmol·L <sup>-1</sup> ) and disrupted protofilament assembly, ultimately leading to bacterial death. Compound 11e exhibited low toxicity and satisfactory drug-likeness properties. Overall, this study indicates that compound 11e as a potent FtsZ inhibitor, highlighting its potential application as a novel bactericide candidate for enhancing the yield and quality of rice and its seeds.<br /> (Copyright © 2025 Elsevier Ltd. All rights reserved.)
ISSN:1873-7072
DOI:10.1016/j.foodchem.2025.146505