Decoding of frequency-modulated sweeps by core and belt neurons in the alert macaque auditory cortex.
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| Název: | Decoding of frequency-modulated sweeps by core and belt neurons in the alert macaque auditory cortex. |
|---|---|
| Autoři: | Malone BJ; Center for Neuroscience, University of California, Davis, California, United States., Recanzone GH; Center for Neuroscience, University of California, Davis, California, United States.; Department of Neurobiology, Physiology and Behavior, University of California, Davis, California, United States. |
| Zdroj: | Journal of neurophysiology [J Neurophysiol] 2025 Nov 01; Vol. 134 (5), pp. 1410-1428. Date of Electronic Publication: 2025 Sep 27. |
| Způsob vydávání: | Journal Article |
| Jazyk: | English |
| Informace o časopise: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Bethesda Md : American Physiological Society Original Publication: Washington [etc.] |
| Výrazy ze slovníku MeSH: | Auditory Cortex*/physiology , Auditory Cortex*/cytology , Neurons*/physiology , Auditory Perception*/physiology, Animals ; Macaca mulatta ; Acoustic Stimulation ; Male ; Action Potentials |
| Abstrakt: | Acoustic stimuli where the spectrum is time-varying are ubiquitous in natural sounds, including animal vocalizations, human speech, and music. Early studies of such stimuli involving frequency-modulated sweeps reveal that neurons in the primary auditory cortex of a variety of mammals show differences in firing rates depending on either the direction of the sweep and/or the sweep velocity. Psychophysical studies have also shown that the perception of such time-varying stimulus parameters is quite acute, underscoring the importance of such signals in normal acoustic perception. The responses of auditory neurons in alert primates have been little studied, and there is limited information relating neural activity to the perception of these signals. In this study, we investigated the neural discriminability of sweep direction and velocity for frequency-modulated sweeps presented to alert rhesus macaque monkeys in both core and belt auditory cortical areas. We quantified how well these information-bearing parameters were encoded using spike train pattern discriminators, and compared decoder performance when neural responses were restricted to temporal patterns or firing rates. Decoding accuracy for firing rate alone exceeded chance, and rate-normalized, spike-timing information was essentially equivalent to the complete firing pattern. Although most belt areas showed small decreases in decoding accuracy relative to the primary field, all fields encoded and represented sweeps similarly. Thus, there was little evidence of hierarchical processing between core and belt fields for these stimuli, indicating that frequency modulation sweep direction and velocity are not specifically extracted in the early auditory cortical hierarchy. NEW & NOTEWORTHY We recorded responses of single neurons in core and belt auditory cortical fields in alert macaque monkeys to frequency-modulated sounds, key feature of many natural sounds, including speech and vocalizations. We found that the timing of neural activity, rather than its magnitude, explained decoding accuracy in all cortical areas, and we did not observe compelling evidence of improved discriminability in core or belt fields beyond that seen in the primary auditory cortex. |
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| Grant Information: | R01 AG034137 United States AG NIA NIH HHS; R01 DC015232 United States DC NIDCD NIH HHS; DC-02371 HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD); DC-021600 HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD); AG-067791 HHS | NIH | National Institute on Aging (NIA); DC-00442 HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD); R56 AG067791 United States AG NIA NIH HHS; R01 DC021600 United States DC NIDCD NIH HHS; R01 AG067791 United States AG NIA NIH HHS; F32 DC000442 United States DC NIDCD NIH HHS |
| Contributed Indexing: | Keywords: auditory cortex; decoding analysis; frequency-modulation; macaque |
| Entry Date(s): | Date Created: 20250927 Date Completed: 20251022 Latest Revision: 20251201 |
| Update Code: | 20251201 |
| PubMed Central ID: | PMC12662255 |
| DOI: | 10.1152/jn.00229.2025 |
| PMID: | 41015502 |
| Databáze: | MEDLINE |
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