Short telomere length is associated with accelerated lung disease progression in rheumatoid arthritis-associated interstitial lung disease.
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| Název: | Short telomere length is associated with accelerated lung disease progression in rheumatoid arthritis-associated interstitial lung disease. |
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| Autoři: | El Husseini K; Université Paris Cité, INSERM, UMR 1149, Centre de Recherche de l'Inflammation, Paris, France kinan.elhusseini@aphp.fr.; Service de Pneumologie, Allergologie et Transplantation Pulmonaire, AP-HP, Hôpital Bichat, Paris, France., Lee JS; Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA., Juge PA; Université Paris Cité, INSERM, UMR 1153, Centre de Recherche en Épidémiologie et Statistiques, Paris, France.; Service de Rhumatologie, AP-HP, Hôpital Bichat, Paris, France., Ebstein E; Service de Rhumatologie, AP-HP, Hôpital Bichat, Paris, France., Ottaviani S; Service de Rhumatologie, AP-HP, Hôpital Bichat, Paris, France., Borie R; Université Paris Cité, INSERM, UMR 1149, Centre de Recherche de l'Inflammation, Paris, France.; Service de Pneumologie, Allergologie et Transplantation Pulmonaire, AP-HP, Hôpital Bichat, Paris, France., Bancal C; Service de Physiologie, AP-HP, Hôpital Bichat, Paris, France., Debray MP; Service de Radiologie, AP-HP, Hôpital Bichat, Paris, France., Kannengiesser C; Université Paris Cité, INSERM, UMR 1149, Centre de Recherche de l'Inflammation, Paris, France.; Service de Génétique, AP-HP, Hôpital Bichat, Paris, France., Ba I; Université Paris Cité, INSERM, UMR 1149, Centre de Recherche de l'Inflammation, Paris, France.; Service de Génétique, AP-HP, Hôpital Bichat, Paris, France., Marchand-Adam S; Service de Pneumologie, CHRU Tours, Tours, France., Richez C; CNRS-UMR 5164, ImmunoConcept, Université de Bordeaux, Bordeaux, France.; Service de Rhumatologie, Centre de Référence des Maladie Autoimmunes et Systémiques Rares, Hôpital Pellegrin, CHU Bordeaux, Bordeaux, France., Nunes H; Université Sorbonne Paris Nord, INSERM, UMR 1272, Bobigny, France.; Service de Pneumologie, Centre de Référence des Maladies Pulmonaires Rares, AP-HP, Hôpital Avicenne, Bobigny, France., Avouac J; Service de Rhumatologie, AP-HP, Hôpital Cochin, Paris, France., Flipo RM; Service de Rhumatologie, CHU Lille, Lille, France., Wemeau L; Service de Pneumologie, CHU Lille, Lille, France., Boissier MC; Service de Rhumatologie, AP-HP, Hôpital Avicenne, Bobigny, France., Schaeverbeke T; Service de Rhumatologie, CHU Bordeaux, Bordeaux, France., Saidenberg Kermanac'h N; Service de Rhumatologie, AP-HP, Hôpital Avicenne, Bobigny, France., Kawano-Dourado L; Hcor Research Institute, Hcor Hospital, Sao Paulo, Brazil.; Pulmonary Division, Heart Institute (InCor), Medical School of the University of Sao Paulo, Sao Paulo, Brazil., Cottin V; Service de Pneumologie, CHU Lyon and Université de Lyon, Lyon, France., Wolters PJ; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA., Granger B; Sorbonne Université, Institut Pierre Louis d'Épidémiologie et de Santé Publique Département de Biostatistiques, INSERM UMR 1136, Paris, France.; Service de Santé Publique et Information Médicale, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France., Dieudé P; Université Paris Cité, INSERM, UMR 1149, Centre de Recherche de l'Inflammation, Paris, France.; Service de Rhumatologie, AP-HP, Hôpital Bichat, Paris, France., Crestani B; Université Paris Cité, INSERM, UMR 1149, Centre de Recherche de l'Inflammation, Paris, France.; Service de Pneumologie, Allergologie et Transplantation Pulmonaire, AP-HP, Hôpital Bichat, Paris, France. |
| Zdroj: | The European respiratory journal [Eur Respir J] 2025 Dec 04; Vol. 66 (6). Date of Electronic Publication: 2025 Dec 04 (Print Publication: 2025). |
| Způsob vydávání: | Journal Article; Observational Study |
| Jazyk: | English |
| Informace o časopise: | Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE |
| Imprint Name(s): | Publication: Sheffield, United Kingdom : European Respiratory Society Original Publication: Copenhagen : Published jointly by the Society and Munksgaard, 1988- |
| Výrazy ze slovníku MeSH: | Arthritis, Rheumatoid*/complications , Lung Diseases, Interstitial*/physiopathology , Lung Diseases, Interstitial*/genetics , Lung Diseases, Interstitial*/etiology , Lung Diseases, Interstitial*/mortality , Lung Diseases, Interstitial*/complications , Telomere* , Telomere Shortening*, Humans ; Male ; Female ; Disease Progression ; Aged ; Middle Aged ; Prospective Studies ; Vital Capacity ; France ; Leukocytes ; Severity of Illness Index ; Lung Transplantation ; Logistic Models ; Lung/physiopathology ; Multivariate Analysis |
| Abstrakt: | Background: Shorter leukocyte telomere length (LTL) has been reported in patients with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) and linked to increased disease severity and mortality in idiopathic pulmonary fibrosis, which shares similarities with RA-ILD. We aimed to evaluate the impact of short LTL on baseline respiratory disease severity, disease progression and survival in patients with RA-ILD. Methods: Patients diagnosed with RA-ILD following multidisciplinary assessment were enrolled in a prospective French observational study. LTL was measured at enrolment using qPCR. Short LTL was defined as age-adjusted LTL <10th percentile. Lung disease progression was defined as death, lung transplantation or functional respiratory decline (absolute decrease in forced vital capacity (FVC) ≥5% predicted or diffusing capacity of the lung for carbon monoxide ( D Results: Among 101 patients with RA-ILD, 46% were male, mean±sd age at enrolment was 66±10 years and 43 (43%) had short LTL. Patients with short LTL had lower FVC % predicted (82% versus 93%) and D Conclusion: Short LTL is associated with baseline severity and 12-month progression in RA-ILD. (Copyright ©The authors 2025. For reproduction rights and permissions contact permissions@ersnet.org.) |
| Entry Date(s): | Date Created: 20250918 Date Completed: 20251204 Latest Revision: 20251204 |
| Update Code: | 20251205 |
| DOI: | 10.1183/13993003.00587-2025 |
| PMID: | 40967766 |
| Databáze: | MEDLINE |
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