The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission.
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| Názov: | The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission. |
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| Autori: | Xiong S; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China., Liang J; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China., Gao S; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China., Liu Z; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China., Zheng H; Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China., Yang X; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China., Wang Y; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. wangyingtmmu2016@126.com., Yu S; Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. shasha102@126.com. |
| Zdroj: | Parasites & vectors [Parasit Vectors] 2025 Aug 02; Vol. 18 (1), pp. 324. Date of Electronic Publication: 2025 Aug 02. |
| Spôsob vydávania: | Journal Article; Review |
| Jazyk: | English |
| Informácie o časopise: | Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central |
| Výrazy zo slovníka MeSH: | Mosquito Vectors*/physiology , Receptors, Odorant*/metabolism , Receptors, Odorant*/physiology , Vector Borne Diseases*/transmission , Vector Borne Diseases*/prevention & control , Culicidae*/physiology , Culicidae*/drug effects, Animals ; Humans ; Mosquito Control/methods ; Insect Repellents/pharmacology ; Female ; Mosquito-Borne Diseases |
| Abstrakt: | Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Mosquitoes are vectors for a variety of infectious diseases, which pose a significant threat to human health, public well-being, and national security. The increasing prevalence of insecticide resistance has further complicated efforts to control these diseases, highlighting the urgent need for innovative strategies to block their transmission. The mosquito olfactory system, which mediates a wide range of behaviors throughout the mosquito's life cycle, including host-seeking, foraging, oviposition, mating, avoidance behavior, and social communication, offers a promising avenue for intervention. Specifically, olfactory receptors play a crucial role in enabling female mosquitoes to locate human hosts through odor recognition, a process that facilitates the transmission of pathogens responsible for diseases such as malaria and dengue fever. Understanding the roles of these receptors in different mosquito behaviors, their mechanisms of odor recognition, and their involvement in disease transmission could provide valuable insights for developing new mosquito control strategies that target olfactory receptors to effectively block disease spread. This review aims to provide a comprehensive summary of the mosquito olfactory system, including its composition, the mechanisms of action of olfactory receptors, their interactions with repellents, and their potential role in the prevention and control of mosquito-borne diseases. (© 2025. The Author(s).) |
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| Grant Information: | 82472319 National Natural Science Foundation of China |
| Contributed Indexing: | Keywords: Mosquito-borne diseases; Olfactory receptors; Repellents; Vector control |
| Substance Nomenclature: | 0 (Receptors, Odorant) 0 (Insect Repellents) |
| Entry Date(s): | Date Created: 20250802 Date Completed: 20250802 Latest Revision: 20250805 |
| Update Code: | 20250805 |
| PubMed Central ID: | PMC12318404 |
| DOI: | 10.1186/s13071-025-06954-1 |
| PMID: | 40753215 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.<br />Mosquitoes are vectors for a variety of infectious diseases, which pose a significant threat to human health, public well-being, and national security. The increasing prevalence of insecticide resistance has further complicated efforts to control these diseases, highlighting the urgent need for innovative strategies to block their transmission. The mosquito olfactory system, which mediates a wide range of behaviors throughout the mosquito's life cycle, including host-seeking, foraging, oviposition, mating, avoidance behavior, and social communication, offers a promising avenue for intervention. Specifically, olfactory receptors play a crucial role in enabling female mosquitoes to locate human hosts through odor recognition, a process that facilitates the transmission of pathogens responsible for diseases such as malaria and dengue fever. Understanding the roles of these receptors in different mosquito behaviors, their mechanisms of odor recognition, and their involvement in disease transmission could provide valuable insights for developing new mosquito control strategies that target olfactory receptors to effectively block disease spread. This review aims to provide a comprehensive summary of the mosquito olfactory system, including its composition, the mechanisms of action of olfactory receptors, their interactions with repellents, and their potential role in the prevention and control of mosquito-borne diseases.<br /> (© 2025. The Author(s).) |
|---|---|
| ISSN: | 1756-3305 |
| DOI: | 10.1186/s13071-025-06954-1 |