Lung clearance index in patients with cystic fibrosis: Can we avoid repeating the test three times?
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| Názov: | Lung clearance index in patients with cystic fibrosis: Can we avoid repeating the test three times? |
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| Autori: | Elbehairy AF; Division of Infection, Immunity, and Respiratory Medicine, The University of Manchester, and Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, United Kingdom; Department of Chest Diseases, Faculty of Medicine, Alexandria University, Alexandria, Egypt. Electronic address: https://twitter.com/AmanyElbehairy., Boorman DY; Medical School, University of Manchester, Manchester, UK., MacNaughton C; Manchester Adult Cystic Fibrosis Centre, Manchester University NHS Foundation Trust, Manchester, UK., Jones AM; Division of Infection, Immunity, and Respiratory Medicine, The University of Manchester, and Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, United Kingdom; Manchester Adult Cystic Fibrosis Centre, Manchester University NHS Foundation Trust, Manchester, UK., Maitra A; Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester, UK., Gilchrist F; Academic Department of Child Health, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK., Horsley A; Division of Infection, Immunity, and Respiratory Medicine, The University of Manchester, and Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, United Kingdom; Manchester Adult Cystic Fibrosis Centre, Manchester University NHS Foundation Trust, Manchester, UK. Electronic address: alexander.horsley@manchester.ac.uk. |
| Zdroj: | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2025 Sep; Vol. 24 (5), pp. 979-981. Date of Electronic Publication: 2025 Aug 05. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam ; New York : Elsevier, c2002- |
| Výrazy zo slovníka MeSH: | Cystic Fibrosis*/physiopathology , Cystic Fibrosis*/diagnosis , Respiratory Function Tests*/methods , Lung*/physiopathology, Humans ; Breath Tests/methods ; Disease Progression |
| Abstrakt: | Competing Interests: Declaration of competing interest AF Elbehairy, DY Boorman, C MacNaughton, A Maitra, and F Gilchrist have nothing to disclose. A Jones reports lecture fees from Vertex Pharmaceuticals. A Horsley reports personal fees from Vertex Pharmaceuticals and grants from CF Trust, Cystic Fibrosis Foundation, NIHR, and JP Moulton Charity outside the submitted work. A Horsley is supported by the NIHR Manchester Biomedical Research Centre. Multiple breath washout (MBW) testing and its derived measurements (e.g., lung clearance index (LCI)) are useful for measuring ventilation heterogeneity in patients with cystic fibrosis, monitoring disease progression, and assessing the response to treatments. However, the use of MBW in routine clinical practice is limited by the long washout time and total test duration, especially in patients with more advanced disease. Recommendations are to complete three MBW repeats. In this analysis, we examine whether two acceptable repeats would provide an accurate assessment of the LCI and could therefore avoid the need for a third measurement, thus reducing total test time. (Copyright © 2025. Published by Elsevier B.V.) |
| Contributed Indexing: | Keywords: Cystic fibrosis; LCI; MBW |
| Entry Date(s): | Date Created: 20250802 Date Completed: 20250927 Latest Revision: 20250927 |
| Update Code: | 20250928 |
| DOI: | 10.1016/j.jcf.2025.07.016 |
| PMID: | 40753053 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declaration of competing interest AF Elbehairy, DY Boorman, C MacNaughton, A Maitra, and F Gilchrist have nothing to disclose. A Jones reports lecture fees from Vertex Pharmaceuticals. A Horsley reports personal fees from Vertex Pharmaceuticals and grants from CF Trust, Cystic Fibrosis Foundation, NIHR, and JP Moulton Charity outside the submitted work. A Horsley is supported by the NIHR Manchester Biomedical Research Centre.<br />Multiple breath washout (MBW) testing and its derived measurements (e.g., lung clearance index (LCI)) are useful for measuring ventilation heterogeneity in patients with cystic fibrosis, monitoring disease progression, and assessing the response to treatments. However, the use of MBW in routine clinical practice is limited by the long washout time and total test duration, especially in patients with more advanced disease. Recommendations are to complete three MBW repeats. In this analysis, we examine whether two acceptable repeats would provide an accurate assessment of the LCI and could therefore avoid the need for a third measurement, thus reducing total test time.<br /> (Copyright © 2025. Published by Elsevier B.V.) |
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| ISSN: | 1873-5010 |
| DOI: | 10.1016/j.jcf.2025.07.016 |