Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non- ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, Indonesia.
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| Title: | Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non- ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, Indonesia. |
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| Authors: | Bintoro SUY; Hematology - Medical Oncology Division, Department of Internal Medicine, Airlangga University, Surabaya, East Java, 60132, Indonesia.; Dr. Soetomo General Teaching Hospital, Surabaya, East Java, 60286, Indonesia., Dwijayanti NMI; Hematology - Medical Oncology Division, Department of Internal Medicine, Airlangga University, Surabaya, East Java, 60132, Indonesia.; Dr. Soetomo General Teaching Hospital, Surabaya, East Java, 60286, Indonesia., Pramudya D; Dr. Soetomo General Teaching Hospital, Surabaya, East Java, 60286, Indonesia., Amrita PN; Hematology - Medical Oncology Division, Department of Internal Medicine, Airlangga University, Surabaya, East Java, 60132, Indonesia.; Dr. Soetomo General Teaching Hospital, Surabaya, East Java, 60286, Indonesia., Romadhon PZ; Hematology - Medical Oncology Division, Department of Internal Medicine, Airlangga University, Surabaya, East Java, 60132, Indonesia.; Dr. Soetomo General Teaching Hospital, Surabaya, East Java, 60286, Indonesia., Asmarawati TP; Dr. Soetomo General Teaching Hospital, Surabaya, East Java, 60286, Indonesia.; Tropical and Infectious Diseases Division, Department of Internal Medicine, Airlangga University, Surabaya, East Java, 60132, Indonesia., Bachtiar A; Dr. Soetomo General Teaching Hospital, Surabaya, East Java, 60286, Indonesia.; Department of Pulmonology and Respiratory Medicine, Airlangga University, Surabaya, East Java, 60132, Indonesia., Hadi U; Dr. Soetomo General Teaching Hospital, Surabaya, East Java, 60286, Indonesia.; Tropical and Infectious Diseases Division, Department of Internal Medicine, Airlangga University, Surabaya, East Java, 60132, Indonesia. |
| Source: | F1000Research [F1000Res] 2021 Aug 11; Vol. 10, pp. 791. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2021). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-1402 (Electronic) Linking ISSN: 20461402 NLM ISO Abbreviation: F1000Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : F1000 Research Ltd |
| MeSH Terms: | COVID-19*, Adult ; Aged ; Hospitals ; Humans ; Indonesia/epidemiology ; Intensive Care Units ; Middle Aged ; Referral and Consultation ; Retrospective Studies ; SARS-CoV-2 |
| Abstract: | Background : This research aimed to examine and analyze risk factors for death, hematologic parameters and coagulation in COVID-19 patients at RSUD Dr. Soetomo Surabaya, one of the referral centers for probable COVID-19 patient cases in East Java. Method : This was a retrospective analytical study by taking secondary data on patients with probable COVID-19 cases who were treated in hospital isolation rooms from May to September, 2020. Result : Of 538 probable COVID-19 patients, 217 were tested positive, with an average age of 52.11±13.12 years, and there were 38 death cases. Hematologic parameters, such as white blood cell, neutrophil and lymphocyte counts, showed significantly different result in the deceased group. On the other hand, coagulation parameters, consisting of D-dimer, CRP, PT, and aPTT showed significantly similar value in the deceased group. Univariate analysis concluded that chronic kidney disease, diabetes mellitus, coronary heart disease, WBC, NLR, and PPT counts could predict the mortality, while multivariate analysis revealed that coronary heart disease was the only significant independent predictor of mortality. Conclusion : This research shows that hematologic and coagulation parameters increased in the majority of COVID-19 patients and the deceased group. While the number of neutrophils and WBC increases, the number of lymphocytes decreases significantly as the disease gets more severe.. Coronary heart disease is an independent predictor of mortality. (Copyright: © 2021 Bintoro SUY et al.) |
| Competing Interests: | No competing interests were disclosed. |
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| Contributed Indexing: | Keywords: COVID-19; and well-being; coagulopathy; comorbid; good health; hematology |
| Molecular Sequence: | figshare 10.6084/m9.figshare.14673060 |
| Entry Date(s): | Date Created: 20211215 Date Completed: 20211217 Latest Revision: 20240404 |
| Update Code: | 20250114 |
| PubMed Central ID: | PMC8596187.3 |
| DOI: | 10.12688/f1000research.53803.3 |
| PMID: | 34904053.3. Version: 3. Publisher Version ID: 3. Version Date: 2021/11/29 |
| Database: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Background : This research aimed to examine and analyze risk factors for death, hematologic parameters and coagulation in COVID-19 patients at RSUD Dr. Soetomo Surabaya, one of the referral centers for probable COVID-19 patient cases in East Java. Method : This was a retrospective analytical study by taking secondary data on patients with probable COVID-19 cases who were treated in hospital isolation rooms from May to September, 2020. Result : Of 538 probable COVID-19 patients, 217 were tested positive, with an average age of 52.11±13.12 years, and there were 38 death cases. Hematologic parameters, such as white blood cell, neutrophil and lymphocyte counts, showed significantly different result in the deceased group. On the other hand, coagulation parameters, consisting of D-dimer, CRP, PT, and aPTT showed significantly similar value in the deceased group. Univariate analysis concluded that chronic kidney disease, diabetes mellitus, coronary heart disease, WBC, NLR, and PPT counts could predict the mortality, while multivariate analysis revealed that coronary heart disease was the only significant independent predictor of mortality. Conclusion : This research shows that hematologic and coagulation parameters increased in the majority of COVID-19 patients and the deceased group. While the number of neutrophils and WBC increases, the number of lymphocytes decreases significantly as the disease gets more severe.. Coronary heart disease is an independent predictor of mortality.<br /> (Copyright: © 2021 Bintoro SUY et al.) |
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| ISSN: | 2046-1402 |
| DOI: | 10.12688/f1000research.53803.3 |