Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA.
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| Title: | Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA. |
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| Authors: | Sigdel TK; Department of Surgery, University of California San Francisco, San Francisco, CA, USA. tara.sigdel@ucsf.edu.; University of California, San Francisco, CA, USA. tara.sigdel@ucsf.edu., Sarwal MM; Department of Surgery, University of California San Francisco, San Francisco, CA, USA. |
| Source: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1788, pp. 11-21. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| MeSH Terms: | Antibodies/*blood , Protein Array Analysis/*methods , Proteomics/*methods, Biomarkers/blood ; Enzyme-Linked Immunosorbent Assay/instrumentation ; Enzyme-Linked Immunosorbent Assay/methods ; Equipment Design ; Humans ; Protein Array Analysis/instrumentation ; Proteomics/instrumentation |
| Abstract: | Because of our access to human genome data and ever-improving genome sequencing and proteome analysis methods, we are much better in terms of our understanding of biological processes. In addition to genomics, proteomics, and other "omics" methods, availability of more sophisticated molecular assaying methods has augmented our knowledge about immune processes toward auto- and allogeneic targets. High-density protein arrays are developed to analyze protein-small molecule interactions, enzyme-substrate profiling, protein-protein interaction, and immune monitoring by assessing antibodies in the serum. |
| Contributed Indexing: | Keywords: Antibodies; Biomarker; ELISA; Immune monitoring; Protein arrays |
| Substance Nomenclature: | 0 (Antibodies) 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20171109 Date Completed: 20190228 Latest Revision: 20190228 |
| Update Code: | 20250114 |
| DOI: | 10.1007/7651_2017_92 |
| PMID: | 29116566 |
| Database: | MEDLINE |
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