Diagnostic devices as biomaterials: a review of nucleic acid and protein microarray surface performance issues.
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| Title: | Diagnostic devices as biomaterials: a review of nucleic acid and protein microarray surface performance issues. |
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| Authors: | Wu P; Department of Chemistry, University of Alberta, Edmonton, AB, Canada T6G 2G2., Castner DG, Grainger DW |
| Source: | Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 2008; Vol. 19 (6), pp. 725-53. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Review |
| Language: | English |
| Journal Info: | Publisher: Taylor and Francis Country of Publication: England NLM ID: 9007393 Publication Model: Print Cited Medium: Print ISSN: 0920-5063 (Print) Linking ISSN: 09205063 NLM ISO Abbreviation: J Biomater Sci Polym Ed Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2012- : Abingdon, Oxon : Taylor and Francis Original Publication: Utrecht, The Netherlands : VSP, c1989- |
| MeSH Terms: | Molecular Diagnostic Techniques/*methods , Oligonucleotide Array Sequence Analysis/*methods , Protein Array Analysis/*methods, Molecular Diagnostic Techniques/instrumentation ; Oligonucleotide Array Sequence Analysis/instrumentation ; Protein Array Analysis/instrumentation |
| Abstract: | This review of current DNA and protein microarray diagnostic and bio-analytical technologies focuses on the different surface chemistries used in these miniaturized surface-capture formats. Description of current strategies in bio-immobilization and coupling to create multiplexed affinity bioassays in micrometer-sized printed spots, problems with current formats and review of some detection methods are included. Recommendations for improving long-standing challenges in DNA- and protein-based arrays are forwarded. The biomaterials community can contribute relevant expertise to these formidable bio-interfacial problems that represent significant barriers to clinical implementation of microarray assays. |
| Number of References: | 166 |
| Grant Information: | R01 EB001473 United States EB NIBIB NIH HHS; EB00726 United States EB NIBIB NIH HHS; EB001473 United States EB NIBIB NIH HHS; EB002027 United States EB NIBIB NIH HHS |
| Entry Date(s): | Date Created: 20080607 Date Completed: 20080826 Latest Revision: 20211020 |
| Update Code: | 20250114 |
| DOI: | 10.1163/156856208784522092 |
| PMID: | 18534094 |
| Database: | MEDLINE |
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