Feasibility of the PHITS code for calculating specific absorbed fraction values in internal dosimetry.
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| Názov: | Feasibility of the PHITS code for calculating specific absorbed fraction values in internal dosimetry. |
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| Autori: | Lee, Min-Gwan1 (AUTHOR), Park, Chanrok1 (AUTHOR) tigeaglepcr@eulji.ac.kr |
| Zdroj: | Radiation Physics & Chemistry. Jan2026, Vol. 238, pN.PAG-N.PAG. 1p. |
| Predmety: | *MEDICAL dosimetry, *MONTE Carlo method, *RADIOPHARMACEUTICALS, *PHOTON transport theory, *ABSORBED dose, *PATIENT safety |
| Abstrakt: | Nuclear medicine imaging is performed by administering radiopharmaceuticals to visualize radiation distribution as the radiopharmaceuticals move toward the target organ. Radiopharmaceuticals can be administered as single or multiple injections depending on the purpose, potentially leading to cumulative radiation exposure. Therefore, accurate internal dosimetry is essential for optimizing therapeutic effects, minimizing side effects, and ensuring patient safety. Monte Carlo simulations, such as Geant4 and Particle and Heavy Ion Transport code System (PHITS), are widely utilized to calculate radiation transport and absorbed doses. Although Geant4 has been highly validated for internal dosimetry, its C++-based structure presents challenges for researchers. In contrast, the PHITS offers a more user-friendly interface for dose calculations, making it an accessible alternative. In this study, we evaluated the feasibility of the PHITS by comparing it with Geant4. Simulations were conducted using the latest mesh-type reference computational phantoms (MRCPs) provided by the International Commission on Radiological Protection (ICRP) and mesh-type reference Korean phantoms (MRKPs) to consider population-specific anatomical variations. Various photon energies (0.1, 1, and 10 MeV) were simulated for multiple source organs (liver, thyroid, heart wall, and gall bladder), assuming a uniform photon distribution within each source organ. Specific absorbed fractions (SAFs) were calculated for multiple radiosensitive organs. The results obtained from the PHITS were quantitatively compared with those from Geant4 using relative difference (RD%) analysis. The results demonstrated a high consistency between the PHITS and Geant4, with the overall RD% variation remaining within 4 %. We confirmed the reliability of the PHITS for internal dose calculations. This study suggests that the PHITS is an alternative internal dosimetry calculation toolkit for Geant4. • PHITS was compared with Geant4 to evaluate its feasibility for internal dosimetry. • Photon transport at 0.1, 1, and 10 MeV was simulated using mesh-type phantoms. • Specific absorbed fractions (SAFs) were calculated using four source organs. • SAFs from PHITS agreed with Geant4 within 4 % across all target organs and energies. • PHITS was validated as a reliable toolkit for patient-specific dosimetry. [ABSTRACT FROM AUTHOR] |
| Databáza: | Academic Search Index |
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