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Evolution and genetic adaptation of fishes to the deep sea.

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Názov: Evolution and genetic adaptation of fishes to the deep sea.
Autori: Xu, Han1,2 (AUTHOR), Fang, Chengchi1,3 (AUTHOR), Xu, Wenjie1,4 (AUTHOR), Wang, Cheng1,2,3 (AUTHOR), Song, Yue1,5 (AUTHOR), Zhu, Chenglong4 (AUTHOR), Fang, Wenyu1,2 (AUTHOR), Fan, Guangyi5 (AUTHOR), Lv, Wenqi2,3 (AUTHOR), Bo, Jing1,2 (AUTHOR), Zeng, Honghui3 (AUTHOR), Sha, Zhongli6 (AUTHOR), Liu, Helu1 (AUTHOR), Jing, Hongmei1 (AUTHOR), Liu, Hao1 (AUTHOR), Wei, Taoshu1 (AUTHOR), Li, Jiwei1 (AUTHOR), He, Lisheng1 (AUTHOR), Cai, Shanya1 (AUTHOR), Gan, Xiaoni3 (AUTHOR)
Zdroj: Cell (0092-8674). Mar2025, Vol. 188 Issue 5, p1393-14140. 12748p.
Predmety: *DEEP-sea fishes, *PERSISTENT pollutants, *EFFECT of environment on fishes, *HADAL zone, *FISH adaptation, *TRIMETHYLAMINE oxide
Abstrakt: The deep sea, especially hadal zones, characterized by high-hydrostatic pressure, low temperatures, and near-total darkness, present some of the most challenging environments for life on Earth. However, teleost fish have successfully colonized these extreme habitats through complex adaptations. We generated genome assemblies of 12 species, including 11 deep-sea fishes. Our findings reconstructed the teleost deep-sea colonization history and revealed the overall impact of the deep-sea environment on fishes. Interestingly, our results question the previously assumed linear correlation between trimethylamine oxide (TMAO) content and depth. By contrast, we observed a convergent aa replacement in the rtf1 gene in most deep-sea fishes under 3,000 m, and in vitro experiments suggest that this mutation can influence transcriptional efficiency, which is likely to be advantageous in the deep-sea environment. Moreover, our study underlines the pervasive impact of human activities, as we detected the presence of persistent organic pollutants in species from the Mariana Trench. [Display omitted] • Genome assembly of 11 deep-sea fishes representing all hadal zone teleost lineages • Convergent Rtf1 mutation across deep-sea fishes influences transcription efficiency • Linear increase of trimethylamine oxide (TMAO) content with depth is not observed • Detection of organic pollutants in deep-sea fish shows pervasive human activity impact Genome assemblies from 11 deep-sea fishes, representing key lineages, reveal a convergent rtf1 gene mutation that affects transcriptional efficiency. Additionally, biochemical measurements challenge the assumption that TMAO content consistently increases with depth, suggesting a more complex mechanism of adaptation. [ABSTRACT FROM AUTHOR]
Databáza: Academic Search Index
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Abstrakt:The deep sea, especially hadal zones, characterized by high-hydrostatic pressure, low temperatures, and near-total darkness, present some of the most challenging environments for life on Earth. However, teleost fish have successfully colonized these extreme habitats through complex adaptations. We generated genome assemblies of 12 species, including 11 deep-sea fishes. Our findings reconstructed the teleost deep-sea colonization history and revealed the overall impact of the deep-sea environment on fishes. Interestingly, our results question the previously assumed linear correlation between trimethylamine oxide (TMAO) content and depth. By contrast, we observed a convergent aa replacement in the rtf1 gene in most deep-sea fishes under 3,000 m, and in vitro experiments suggest that this mutation can influence transcriptional efficiency, which is likely to be advantageous in the deep-sea environment. Moreover, our study underlines the pervasive impact of human activities, as we detected the presence of persistent organic pollutants in species from the Mariana Trench. [Display omitted] • Genome assembly of 11 deep-sea fishes representing all hadal zone teleost lineages • Convergent Rtf1 mutation across deep-sea fishes influences transcription efficiency • Linear increase of trimethylamine oxide (TMAO) content with depth is not observed • Detection of organic pollutants in deep-sea fish shows pervasive human activity impact Genome assemblies from 11 deep-sea fishes, representing key lineages, reveal a convergent rtf1 gene mutation that affects transcriptional efficiency. Additionally, biochemical measurements challenge the assumption that TMAO content consistently increases with depth, suggesting a more complex mechanism of adaptation. [ABSTRACT FROM AUTHOR]
ISSN:00928674
DOI:10.1016/j.cell.2025.01.002