Suchergebnisse - MicroRNA Regulation in Cancer and Development

The Role of miRNAs in Mechanotransduction Regulation and Cancer Development.

Autoren: Vela-AlcáNtara, Ana M. HernáNdez-SáNchez, Diego J. Tamariz, Elisa

Quelle: Biocell. 2025, Vol. 49 Issue 9, p1663-1695. 33p.

Schlagwörter: *MICRORNA, *MECHANOTRANSDUCTION (Cytology), *PROTEIN expression, *COMPRESSIVE force, *CANCER invasiveness, *CARCINOGENESIS, *CYTOLOGY, *GENE expression

Role of the transcribed pseudogene RPSAP52 in gene expression regulation in cancer

Autoren: Kumar, Deepthi Ramesh

Weitere Verfasser: University/Department: Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut

Thesis Advisors: Guil Domènech, Sònia, Esteller Badosa, Manel

Quelle: TDX (Tesis Doctorals en Xarxa)

Schlagwörter: Genètica humana, Genética humana, Human genetics, Oncologia, Oncología, Oncology, Cultiu cel·lular, Cultivo celular, Cell culture, Ciències de la salut, Ciencias biomédicas, Medical sciences, Ciències de la Salut

Dateibeschreibung: application/pdf

Zugangs-URL: http://hdl.handle.net/10803/694144

Regulation of autophagy by microRNAs in human breast cancer

Autoren: Zhi Xiong Chong Swee Keong Yeap Wan Yong Ho

Quelle: J Biomed Sci
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-18 (2021)

Schlagwörter: FOS: Computer and information sciences, 0301 basic medicine, Cancer Research, MicroRNA Regulation in Cancer and Development, Epidemiology, Bioinformatics, Breast Neoplasms, Role of Long Noncoding RNAs in Cancer and Development, Apoptosis, Review, Cancer research, Gene, 03 medical and health sciences, Breast cancer, Role of Autophagy in Disease and Health, Biochemistry, Genetics and Molecular Biology, Health Sciences, Biomarkers, Tumor, Autophagy, Genetics, Humans, Biology, Cancer, 0303 health sciences, Therapeutic agents, microRNA, RNA Regulation, Mitophagy, Life Sciences, 3. Good health, Gene Expression Regulation, Neoplastic, MicroRNAs, FOS: Biological sciences, miRNAs, Medicine, Female, Biomarkers, Signal Transduction

Zugangs-URL: https://jbiomedsci.biomedcentral.com/track/pdf/10.1186/s12929-021-00715-9
https://pubmed.ncbi.nlm.nih.gov/33761957
https://doaj.org/article/5bf5f00fbe494373bb38108d48609ee0
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00715-9
https://www.ncbi.nlm.nih.gov/pubmed/33761957
https://link.springer.com/content/pdf/10.1186/s12929-021-00715-9.pdf
https://pubmed.ncbi.nlm.nih.gov/33761957/
https://europepmc.org/article/MED/33761957
https://link.springer.com/article/10.1186/s12929-021-00715-9

Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review

Autoren: Maryam Sadeghi Mohadeseh lotfi Narges Soltani et al.

Quelle: Cancer Cell Int
Cancer Cell International, Vol 23, Iss 1, Pp 1-30 (2023)

Schlagwörter: FOS: Computer and information sciences, Cancer Research, MicroRNA Regulation in Cancer and Development, Bioinformatics, Role of Long Noncoding RNAs in Cancer and Development, Review, Cancer research, NSCLC, Gene, Metastasis, Biochemistry, Genetics and Molecular Biology, Pathology, Genetics, Biogenesis and Functions of Circular RNAs, Molecular Biology, Biology, Internal medicine, RC254-282, Cancer, QH573-671, microRNA, RNA Regulation, SCLC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Life Sciences, Malignancy, MicroRNA, Cancer Biomarkers, Small Cell Lung Carcinoma, 3. Good health, Treatment, MicroRNAs, Oncology, FOS: Biological sciences, Medicine, Small-cell carcinoma, Epigenetics, Angiogenesis, Lung cancer, Cytology

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37986065
https://doaj.org/article/53080681947c46faad0ebd523dd72e70

The Implication of microRNAs as non-invasive biomarkers in 179 Egyptian breast cancer female patients

Autoren: NADIA Z. SHAABAN Nashwa K. Ibrahim Helen N. Saada et al.

Quelle: Oncol Res

Schlagwörter: Cancer Research, MicroRNA Regulation in Cancer and Development, Carcinogenesis, Breast Neoplasms, Role of Long Noncoding RNAs in Cancer and Development, Cancer research, Cell cycle, Gene, Article, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, Biochemistry, Genetics and Molecular Biology, Genetics, Humans, Chemotherapy, Biogenesis and Functions of Circular RNAs, Tumor suppressor gene, Suppressor, Molecular Biology, Internal medicine, Biology, Oncogene, Cancer, microRNA, RNA Regulation, Life Sciences, Oncogenes, Cancer Biomarkers, 3. Good health, MicroRNAs, Oncology, FOS: Biological sciences, Medicine, Female, Egypt, Gene expression, Biomarkers

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37303494

Functionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies

Autoren: Shaymaa A. Abdulmalek Abdulrahman M. Saleh Yasmin R. Shahin et al.

Quelle: Naunyn Schmiedebergs Arch Pharmacol

Schlagwörter: 0301 basic medicine, Cancer Research, Cell biology, MicroRNA Regulation in Cancer and Development, siRNA Delivery, Triple Negative Breast Neoplasms, Cancer cell, Apoptosis, Cancer research, Signal transduction, DNA Nanotechnology and Bioanalytical Applications, Transfection, Biochemistry, Gene, 03 medical and health sciences, Breast cancer, Triple-negative breast cancer, Protein kinase B, Cell Movement, Cell Line, Tumor, Biochemistry, Genetics and Molecular Biology, Genetics, Humans, RNA, Small Interfering, Molecular Biology, Biology, Cell Proliferation, Cancer, Chitosan, 0303 health sciences, microRNA, Research, Mechanisms and Applications of RNA Interference, Life Sciences, Small interfering RNA, 3. Good health, MicroRNAs, Chemistry, FOS: Biological sciences, PI3K/AKT/mTOR pathway, Nanoparticles, Female, siRNA Therapeutics, MAPK/ERK pathway, Cell culture, Proto-Oncogene Proteins c-akt, Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38592437

Evaluation of microRNA 92a Expression and Its Target Protein Bim in Colorectal Cancer

Autoren: Ahmed A. Zaki Amal Fawzy Samia Akel et al.

Quelle: Asian Pac J Cancer Prev

Schlagwörter: Male, Adenoma, Cancer Research, MicroRNA Regulation in Cancer and Development, TaqMan, Exosome Biology and Function in Intercellular Communication, Gene, Biochemistry, Real-time polymerase chain reaction, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Biochemistry, Genetics and Molecular Biology, Biomarkers, Tumor, Pathology, Humans, Biogenesis and Functions of Circular RNAs, Molecular Biology, Internal medicine, Biology, Cancer, Bcl-2-Like Protein 11, microRNA, Gene Expression Profiling, Gastroenterology, Life Sciences, Malignancy, Cancer Biomarkers, Middle Aged, Colorectal cancer, 3. Good health, MicroRNAs, ROC Curve, Oncology, Case-Control Studies, Medicine, Female, Colorectal Neoplasms, Research Article

Zugangs-URL: http://journal.waocp.org/article_89995_b894de5203c99b62ccb3fa070a77c7c4.pdf
https://pubmed.ncbi.nlm.nih.gov/35225486

Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development.

Autoren: Leonard R Zhao Y Eliason S et al.

Quelle: Nature communications [Nat Commun] 2025 Jul 29; Vol. 16 (1), pp. 6947. Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , MicroRNAs*/genetics , MicroRNAs*/metabolism , Heart*/embryology, Animals ; Mice ; Cell Differentiation/genetics ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Gene Expression Regulation, Developmental ; GATA4 Transcription Factor/genetics ; GATA4 Transcription Factor/metabolism ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism ; Homeodomain Proteins/metabolism ; Homeodomain Proteins/genetics ; MEF2 Transcription Factors/genetics ; MEF2 Transcription Factors/metabolism ; Homeobox Protein PITX2 ; Single-Cell Analysis ; Multiomics

MicroRNAs’ role in the environment-related non-communicable diseases and link to multidrug resistance, regulation, or alteration

Autoren: Mohamed Mahmoud Eman F. Sanad Nadia M. Hamdy

Quelle: Environmental Science and Pollution Research. 28:36984-37000

Schlagwörter: FOS: Computer and information sciences, 0301 basic medicine, Cancer Research, MicroRNA Regulation in Cancer and Development, Bioinformatics, Multiple drug resistance, 02 engineering and technology, 01 natural sciences, Gene, Computational biology, 03 medical and health sciences, Biochemistry, Genetics and Molecular Biology, 0202 electrical engineering, electronic engineering, information engineering, Biomarkers, Tumor, Genetics, Humans, Biogenesis and Functions of Circular RNAs, Noncommunicable Diseases, Molecular Biology, Biology, 0105 earth and related environmental sciences, Cancer, 0303 health sciences, mRNA modification, microRNA, Life Sciences, Drug Resistance, Multiple, 3. Good health, Gene Expression Regulation, Neoplastic, MicroRNAs, Gene Expression Regulation, RNA Methylation and Modification in Gene Expression, Drug resistance, FOS: Biological sciences, Biomarkers, tRNA fragments

Zugangs-URL: https://www.preprints.org/manuscript/202102.0278/v1/download
https://pubmed.ncbi.nlm.nih.gov/34046834
https://www.ncbi.nlm.nih.gov/pubmed/34046834
https://europepmc.org/article/MED/34046834
https://pubmed.ncbi.nlm.nih.gov/34046834/
https://link.springer.com/article/10.1007/s11356-021-14550-w

Functional Role of MicroRNAs in Embryogenesis

Autoren: Muhammad Babar Khawar Huma Rasheed Ali Afzal et al.

Quelle: Genetics ISBN: 9781803567105

Schlagwörter: FOS: Computer and information sciences, Cancer Research, Cell biology, MicroRNA Regulation in Cancer and Development, Bioinformatics, Organogenesis, Epistemology, Gene, Computational biology, Biochemistry, Genetics and Molecular Biology, Genetics, Biogenesis and Functions of Circular RNAs, Molecular Mechanisms of Cardiac Development and Regeneration, Molecular Biology, Biology, microRNA, Life Sciences, Mechanism (biology), FOS: Philosophy, ethics and religion, MicroRNAs, Embryonic stem cell, Philosophy, Embryo, FOS: Biological sciences, Embryogenesis, Neuroscience

Zugangs-URL: https://mts.intechopen.com/articles/show/title/functional-role-of-micrornas-in-embryogenesis

Influence of RNA circularity on Target RNA-Directed MicroRNA Degradation

Autoren: Federico Fuchs Wightman Jerónimo Lukin Sebastián A. Giusti et al.

Quelle: Nucleic Acids Res
Fuchs Wightman, Federico; Lukin, Jerónimo; Giusti, Sebastián A; Soutschek, Michael; Bragado, Laureano; Pozzi, Berta; Pierelli, María L; González, Paula; Fededa, Juan P; Schratt, Gerhard; Fujiwara, Rina; Wilusz, Jeremy E; Refojo, Damián; de la Mata, Manuel (2024). Influence of RNA circularity on Target RNA-Directed MicroRNA Degradation. Nucleic acids research, 52(6), pp. 3358-3374. Oxford University Press 10.1093/nar/gkae094 <http://dx.doi.org/10.1093/nar/gkae094>
Nucleic Acids Research, 52 (6)

Schlagwörter: Cancer Research, Cell biology, Medical Sciences, MicroRNA Regulation in Cancer and Development, RNA Stability, Biophysics, Circular, Biochemistry, Gene, Computational biology, Mice, Biochemistry, Genetics and Molecular Biology, RNA topology, Medical Specialties, Medicine and Health Sciences, RNA and RNA-protein complexes, MicroRNA Sponges, Genetics, Humans, Animals, Biogenesis and Functions of Circular RNAs, Non-coding RNA, Molecular Biology, Circular RNA, Biology, microRNA, Life Sciences, RNA, Circular, Small RNA, microRNAs, MicroRNAs, FOS: Biological sciences, Regulation of RNA Processing and Function, and Structural Biology, 570 Life sciences, biology, RNA, circRNAs, Circular RNAs, mRNA Decay

Dateibeschreibung: application/pdf; application/application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38381063
https://boris.unibe.ch/193152/
http://hdl.handle.net/11336/267453
http://hdl.handle.net/20.500.11850/662866

Standardized Polyalthia longifolia leaf extract induces the apoptotic HeLa cells death via microRNA regulation: identification, validation, and therapeutic potential

Autoren: Soundararajan Vijayarathna Chern Ein Oon Majid Al-Zahrani et al.

Quelle: Front Pharmacol
Frontiers in Pharmacology, Vol 14 (2023)

Schlagwörter: 0301 basic medicine, Cancer Research, Cell biology, MicroRNA Regulation in Cancer and Development, Cytotoxicity, standardized extract, Apoptosis, Cancer cell, RM1-950, Medical Applications, anticancer, Applied Microbiology and Biotechnology, Gene, Biochemistry, Polyalthia longifolia, HeLa, 03 medical and health sciences, In vitro, Biochemistry, Genetics and Molecular Biology, Genetics, Biology, miRNA, Programmed cell death, Cancer, Pharmacology, Immunology and Microbiology, 2. Zero hunger, 0303 health sciences, Microbial Tannase Production and Applications, microRNA, apoptosis, Life Sciences, 15. Life on land, 3. Good health, FOS: Biological sciences, gene ontology, Therapeutics. Pharmacology, Cell

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37693900
https://doaj.org/article/f880068e4d3d43198a942c7a7eb8d835

Restoring microRNA-34a overcomes acquired drug resistance and disease progression in human breast cancer cell lines via suppressing the ABCC1 gene

Autoren: Shaymaa M. M. Yahya Heba K. Nabih Ghada H. Elsayed et al.

Quelle: Breast Cancer Res Treat

Schlagwörter: Cancer Research, MicroRNA Regulation in Cancer and Development, ABCC1, Breast Neoplasms, Cancer cell, Cancer research, Transporter, Gene, Metastasis, Breast cancer, Cell Line, Tumor, Biochemistry, Genetics and Molecular Biology, ATP-binding cassette transporter, Genetics, Humans, Biogenesis and Functions of Circular RNAs, Molecular Biology, Biology, Cancer, Original Laboratory Investigation, microRNA, Mechanisms and Applications of RNA Interference, Life Sciences, Gene silencing, 3. Good health, Gene Expression Regulation, Neoplastic, MicroRNAs, Doxorubicin, Drug Resistance, Neoplasm, Drug resistance, FOS: Biological sciences, Disease Progression, MCF-7 Cells, Female, Multidrug Resistance-Associated Proteins

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38057687

The key role of microRNA-766 in the cancer development

Autoren: Jitendra Gupta Hussein Riyadh Abdul Kareem Al-Hetty Murtadha Sh. Aswood et al.

Quelle: Front Oncol
Frontiers in Oncology, Vol 13 (2023)

Schlagwörter: FOS: Computer and information sciences, Cancer Research, MicroRNA Regulation in Cancer and Development, Bioinformatics, Role of Long Noncoding RNAs in Cancer and Development, Cancer research, Cell cycle, Gene, Computational biology, Biochemistry, Genetics and Molecular Biology, Genetics, cancer, Biogenesis and Functions of Circular RNAs, Molecular Biology, Biology, RC254-282, Cancer, drug resistance, microRNA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Life Sciences, miR-766, Biomarker, 3. Good health, MicroRNAs, Oncology, FOS: Biological sciences, biomarker

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37205191
https://doaj.org/article/acbde08e678d4fc795cb3882a4d809df

Rebound increase in microRNA levels at the end of 5-FU-based therapy in colorectal cancer patients

Autoren: Doaa M Badr Mahmoud Fouad Marwa M. Hussein et al.

Quelle: Sci Rep
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Schlagwörter: Cancer Research, PTEN, MicroRNA Regulation in Cancer and Development, Science, Role of Long Noncoding RNAs in Cancer and Development, Apoptosis, Gene, Biochemistry, Article, Biochemistry, Genetics and Molecular Biology, Humans, Circulating MicroRNA, Biogenesis and Functions of Circular RNAs, Molecular Biology, Internal medicine, Biology, Cancer, microRNA, Life Sciences, Colorectal cancer, 3. Good health, ErbB Receptors, MicroRNAs, Oncology, PI3K/AKT/mTOR pathway, Medicine, Epigenetics, Fluorouracil, Colorectal Neoplasms

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37648713
https://doaj.org/article/c63dc05318ef4c508e79af39b637dcd3

The interplay of sex steroid hormones and microRNAs in endometrial cancer: current understanding and future directions

Autoren: Lovlesh Thakur Sunil Thakur

Quelle: Front Endocrinol (Lausanne)
Frontiers in Endocrinology, Vol 14 (2023)

Schlagwörter: FOS: Computer and information sciences, Cancer Research, MicroRNA Regulation in Cancer and Development, Bioinformatics, Sex steroid, progesterone, Gene, Diseases of the endocrine glands. Clinical endocrinology, Computational biology, Phosphatidylinositol 3-Kinases, Endocrinology, Endometrial cancer, Biochemistry, Genetics and Molecular Biology, Health Sciences, estrogen, Genetics, Humans, Current (fluid), Biogenesis and Functions of Circular RNAs, Gonadal Steroid Hormones, Molecular Biology, Steroid, Biology, Internal medicine, Cancer, hormone therapy, microRNA, Physics, Obstetrics and Gynecology, Life Sciences, Estrogens, Gynecologic Oncology, RC648-665, Hormone, 3. Good health, Endometrial Neoplasms, MicroRNAs, FOS: Biological sciences, endometrial cancer, sex steroid hormones, Medicine, Thermodynamics, Female

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37152960
https://doaj.org/article/ca173b4ff0364035b4c1726687487d9d

Predicting SNPs in Mature MicroRNAs Dysregulated in Breast Cancer

Autoren: Thanh Thi Ngoc Nguyen Thu Huynh Ngoc Nguyen Luan Huu Huynh et al.

Quelle: Recent Advances in Noncoding RNAs ISBN: 9781803560144
Recent Advances in Noncoding RNAs

Schlagwörter: FOS: Computer and information sciences, Cancer Research, MicroRNA Regulation in Cancer and Development, Genotype, Carcinogenesis, Bioinformatics, Role of Long Noncoding RNAs in Cancer and Development, Gene, Computational biology, Breast cancer, Biochemistry, Genetics and Molecular Biology, Genetics, Biogenesis and Functions of Circular RNAs, Molecular Biology, Biology, Cancer, Single-nucleotide polymorphism, Allele, microRNA, RNA Regulation, In silico, Life Sciences, 3. Good health, MicroRNAs, Function (biology), FOS: Biological sciences

Zugangs-URL: https://mts.intechopen.com/articles/show/title/predicting-snps-in-mature-micrornas-dysregulated-in-breast-cancer

Salivaomics to decode non-coding RNAs in oral cancer. A narrative review

Autoren: Peramaiyan Rajendran Ramya Sekar Hamad Abu Zahra et al.

Quelle: Non-coding RNA Research, Vol 8, Iss 3, Pp 376-384 (2023)

Schlagwörter: FOS: Computer and information sciences, Cancer Research, MicroRNA Regulation in Cancer and Development, Bioinformatics, Role of Long Noncoding RNAs in Cancer and Development, QH426-470, Gene, Biochemistry, Genetics and Molecular Biology, Genetics, Disease, Biogenesis and Functions of Circular RNAs, Saliva, Non-coding RNA, Molecular Biology, Biology, Internal medicine, Cancer, Liquid biopsy, microRNA, Oral cancer, Life Sciences, Biomarker, Non coding RNA, 3. Good health, Point-of-care, FOS: Biological sciences, Medicine, Epigenetics, Microvesicles

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37250455
https://doaj.org/article/92911e34a3744a76892632355a0d6a99

Targeted therapy using nanocomposite delivery systems in cancer treatment: highlighting miR34a regulation for clinical applications

Autoren: Muhammad Javed Iqbal Zeeshan Javed Haleema Sadia et al.

Quelle: Cancer Cell Int
Cancer Cell International, Vol 23, Iss 1, Pp 1-12 (2023)

Schlagwörter: FOS: Computer and information sciences, Cancer Research, MicroRNA Regulation in Cancer and Development, Bioinformatics, siRNA Delivery, cancer treatment, miR34a, p53 signaling, tumorigenesis, nano-delivery systems, Cancer cell, Review, Cancer research, Gene, Metastasis, Nanoparticle, Biochemistry, Genetics and Molecular Biology, Genetics, Nanotechnology, Molecular Biology, Biology, Internal medicine, RC254-282, Cancer, FOS: Nanotechnology, Therapeutic RNAi, mRNA modification, QH573-671, microRNA, Mechanisms and Applications of RNA Interference, Regulator, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Life Sciences, Materials science, 3. Good health, MicroRNAs, Nanomedicine, RNA Methylation and Modification in Gene Expression, FOS: Biological sciences, Medicine, siRNA Therapeutics, Cytology

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37149609
https://doaj.org/article/590925a262144000b3219a7fbd4a04cf

MicroRNA-200 Loaded Lipid Nanoparticles Promote Intestinal Epithelium Regeneration in Canonical MicroRNA-Deficient Mice

Autoren: Xiyang Wei Shicheng Yu Tinghong Zhang et al.

Quelle: ACS Nano

Schlagwörter: Cancer Research, Cell biology, MicroRNA Regulation in Cancer and Development, Immunology, Cancer research, Gene, Epithelium, Mice, Biochemistry, Genetics and Molecular Biology, Health Sciences, Intestinal mucosa, Genetics, Humans, Animals, Regeneration, Biogenesis and Functions of Circular RNAs, Intestinal epithelium, Intestinal Mucosa, Hyperactivation, Molecular Biology, Biology, Internal medicine, Stem cell, microRNA, FOS: Clinical medicine, RNA-Binding Proteins, Life Sciences, Downregulation and upregulation, Intestines, MicroRNAs, Oncology, Cancer Stem Cells and Tumor Metastasis, FOS: Biological sciences, Regeneration (biology), Medicine, Colitis, Ulcerative, Tumor Suppressor Protein p53

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37939210