Výsledky vyhledávání - Integrative computational algorithm

Discovery of an AKT1-targeting compound from a traditional herbal formula for alcoholic liver disease via integrative computational and experimental approaches.

Autoři: Yang, Shuxuan Zou, Caiting Li, Dexian a další

Zdroj: Chinese Medicine. 10/7/2025, Vol. 20 Issue 1, p1-22. 22p.

Témata: *CHINESE medicine, *PROTEIN kinase inhibitors, *CLINICAL drug trials, *RANDOM forest algorithms, *COMPUTER-assisted molecular modeling, *IN vitro studies, *HIGH performance liquid chromatography, *BIOLOGICAL models, *RESEARCH funding, *CLUSTER analysis (Statistics), *HERBAL medicine, *TERPENES, *LOGISTIC regression analysis, *PHARMACEUTICAL chemistry, *ALCOHOLIC liver diseases, *PHYTOCHEMICALS, *IN vivo studies, *FISHES, *DESCRIPTIVE statistics, *BIOINFORMATICS, *EXPERIMENTAL design, *SUPPORT vector machines, *CELL culture, *ANIMAL experimentation, *MOLECULAR structure, *GENE expression profiling, *LIVER, *DRUG development, *MACHINE learning, *METABOLOMICS, *CELL survival, *STAINS & staining (Microscopy), *DRUG discovery, *ANALYTICAL chemistry, *ALGORITHMS, *DRUG dosage, *PHARMACODYNAMICS, *DRUG administration

Robotic Prototype with Human Mimicry Abilities - 104 Algorithms (RPHMA 104a ): Toward an Integrative Computational-Robotic Theory of Very Complex Skills

Autoři: Maicon S. Aliaga Machado

Témata: Assistive robots and technology, Biomechatronics, Control engineering, Field robotics, Manufacturing robotics, Medical robotics, Micro-manipulation, Simulation, modelling, and programming of mechatronics systems, mechatronics and robotics not elsewhere classified, Artificial life and complex adaptive systems, Autonomous agents and multiagent systems, Evolutionary computation, Fuzzy computation, Intelligent robotics, Knowledge representation and reasoning, Modelling and simulation, Natural language processing, Planning and decision making, Artificial intelligence not elsewhere classified, Cognitive-behavioral functions, HMS-1 to HMS-5, Very Complex Skills, Advanced computational techniques, Cognitive robotics, Unified computational theory

Dostupnost: https://doi.org/10.6084/m9.figshare.29006996.v2
https://figshare.com/articles/dataset/RPHMS104A_-_Robotic_Prototype_Concept_Preprint_pdf/29006996

An integrative computational architecture for object-driven cortex

Autoři: Joshua B. Tenenbaum Jiajun Wu Nancy Kanwisher a další

Přispěvatelé: Joshua B. Tenenbaum Jiajun Wu Nancy Kanwisher a další

Zdroj: PMC

Témata: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Artificial Intelligence, Brain, Humans, Recognition, Psychology, Neural Networks, Computer, Algorithms

Popis souboru: application/pdf

Přístupová URL adresa: https://www.sciencedirect.com/science/article/am/pii/S0959438818301995
https://pubmed.ncbi.nlm.nih.gov/30825704
https://www.sciencedirect.com/science/article/pii/S0959438818301995
https://www.ncbi.nlm.nih.gov/pubmed/30825704
https://hdl.handle.net/1721.1/124676

Unlocking hematopoietic stem cell potential: integrative computational approaches for genomic and transcriptomic analysis.

Autoři: Raghav, Pawan Kumar Banerjee, Basudha Chadha, Rajni

Zdroj: Frontiers in Cell & Developmental Biology; 2025, p1-13, 13p

Témata: HEMATOPOIETIC stem cells, COMPUTATIONAL biology, STEM cell treatment, RNA sequencing, BLOOD diseases, GENE regulatory networks, MACHINE learning

Unlocking hematopoietic stem cell potential: integrative computational approaches for genomic and transcriptomic analysis

Autoři: Pawan Kumar Raghav Basudha Banerjee Rajni Chadha

Zdroj: Frontiers in Cell and Developmental Biology. 13

An Integrative Computational Approach for Identifying Cotton Host Plant MicroRNAs with Potential to Abate CLCuKoV-Bur Infection.

Autoři: Ashraf MA Shahid I Brown JK a další

Zdroj: Viruses [Viruses] 2025 Mar 12; Vol. 17 (3). Date of Electronic Publication: 2025 Mar 12.

Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Výrazy ze slovníku MeSH: Gossypium*/virology , Gossypium*/genetics , MicroRNAs*/genetics , MicroRNAs*/metabolism , Begomovirus*/genetics , Plant Diseases*/virology , Plant Diseases*/genetics , Computational Biology*/methods , Host-Pathogen Interactions*, Open Reading Frames ; RNA Interference

Pathway Maps of Orphan and Complex Diseases Using an Integrative Computational Approach

Autoři: Kais Ghedira Imen Rabhi Sadri Znaidi a další

Zdroj: Biomed Res Int
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria

Témata: 0301 basic medicine, 0303 health sciences, Computational Biology, Apoptosis, 3. Good health, 03 medical and health sciences, Rare Diseases, Neoplasms, Databases, Genetic, Mutation, Animals, Humans, Computer Simulation, Gene Regulatory Networks, Protein Interaction Maps, Algorithms, Research Article, Signal Transduction

Popis souboru: application/pdf; text/xhtml

Přístupová URL adresa: https://downloads.hindawi.com/journals/bmri/2020/4280467.pdf
https://pubmed.ncbi.nlm.nih.gov/33376724
https://hdl.handle.net/10641/3734
https://pubmed.ncbi.nlm.nih.gov/33376724/
http://downloads.hindawi.com/journals/bmri/2020/4280467.pdf
https://www.hindawi.com/journals/bmri/2020/4280467/
https://www.ncbi.nlm.nih.gov/pubmed/33376724
https://downloads.hindawi.com/journals/bmri/2020/4280467.pdf
https://europepmc.org/article/MED/33376724

Developing integrative computational models of pulmonary structure

Autoři: Tawhai, M Burrowes, K

Zdroj: The Anatomical Record Part B: The New Anatomist. :207-218

Témata: 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Finite Element Analysis, 0206 medical engineering, Computational Biology, Humans, 02 engineering and technology, Lung, Models, Biological, Algorithms, 3. Good health

Přístupová URL adresa: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ar.b.10034
https://pubmed.ncbi.nlm.nih.gov/14628321
https://pubmed.ncbi.nlm.nih.gov/14628321/
https://europepmc.org/article/MED/14628321
http://onlinelibrary.wiley.com/doi/10.1002/ar.b.10034/abstract
https://www.ncbi.nlm.nih.gov/pubmed/14628321
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar.b.10034
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/ar.b.10034
https://ora.ox.ac.uk/objects/uuid:f7888946-88f3-4611-a778-f8d2977ba0bf

An integrative computational framework based on a two-step random forest algorithm improves prediction of zinc-binding sites in proteins.

Autoři: Cheng Zheng Mingjun Wang Kazuhiro Takemoto a další

Zdroj: PLoS ONE, Vol 7, Iss 11, p e49716 (2012)

Témata: Medicine, Science

Popis souboru: electronic resource

Relation: http://europepmc.org/articles/PMC3499040?pdf=render; https://doaj.org/toc/1932-6203

Přístupová URL adresa: https://doaj.org/article/ebd6b62b0bfa4adb82b65bc7cb2c7c2c

sRNAPredict: an integrative computational approach to identify sRNAs in bacterial genomes

Autoři: Matthew K. Waldor Michael A. Fogel Jonathan Livny a další

Zdroj: Nucleic Acids Res

Témata: 0301 basic medicine, 0303 health sciences, RNA, Untranslated, Computational Biology, Genomics, Blotting, Northern, Article, Systems Integration, RNA, Bacterial, 03 medical and health sciences, Escherichia coli, DNA, Intergenic, Vibrio cholerae, Algorithms, Conserved Sequence, Genome, Bacterial, Software

Přístupová URL adresa: https://academic.oup.com/nar/article-pdf/33/13/4096/3823479/gki715.pdf
https://pubmed.ncbi.nlm.nih.gov/16049021
https://core.ac.uk/display/22407855
http://www.ncbi.nlm.nih.gov/pubmed/16049021
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/16049021/
https://academic.oup.com/nar/article-abstract/33/13/4096/1094437
https://pubmed.ncbi.nlm.nih.gov/16049021/
https://paperity.org/p/34400738/srnapredict-an-integrative-computational-approach-to-identify-srnas-in-bacterial-genomes

Nutrition for Precision Health, Powered by the All of Us

Autoři: National Institutes of Health (NIH) University of North Carolina, Chapel Hill Northwestern University a další

Zdroj: Nutrition for Precision Health, Powered by the All of Us Research Program

Other URLs: https://researchallofus.org/data-tools/workbench/

Computational modelling of detected persistent organic pollutants in adriatic pelagic fish: molecular and toxicokinetic perspectives for human health risk assessment.

Autoři: Obradović, D. Romanić, S.H. Mustać, B. a další

Zdroj: SAR & QSAR in Environmental Research; Oct2025, Vol. 36 Issue 10, p927-954, 28p

Témata: PERSISTENT pollutants, HEALTH risk assessment, MULTIPLE regression analysis, PELAGIC fishes, COMPUTER simulation, BIOACCUMULATION, PHARMACOKINETICS, GENETIC algorithms

Geografický termín: ADRIATIC Sea

DCPPS: Prediction of Kinase-Specific Phosphorylation Sites Using Dynamic Embedding and Cross-Representation Interaction.

Autoři: Liu M Wang X Sun ZL a další

Zdroj: Interdisciplinary sciences, computational life sciences [Interdiscip Sci] 2025 Dec; Vol. 17 (4), pp. 1056-1073. Date of Electronic Publication: 2025 Jun 11.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101515919 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1867-1462 (Electronic) Linking ISSN: 18671462 NLM ISO Abbreviation: Interdiscip Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Computational Biology*/methods , Protein Kinases*/metabolism , Protein Kinases*/chemistry , Phosphotransferases*/metabolism, Phosphorylation ; Humans ; Algorithms

Integrative computational approaches identify haptoglobin inhibitors to modulate erythrocyte sedimentation rate in trauma-linked inflammatory and haematological malignancies.

Autoři: Al Khzem, Abdulaziz H. Ahmad, Shaban

Zdroj: Frontiers in Chemistry; 2025, p1-28, 28p

Témata: COMPUTATIONAL chemistry, BLOOD sedimentation, PHARMACEUTICAL chemistry, HIGH throughput screening (Drug development), DENSITY functional theory, PROTEIN-ligand interactions, HAPTOGLOBINS

Integrative computational approach identifies immune‐relevant biomarkers in ulcerative colitis

Autoři: Tianzhen He Kai Wang Peng Zhao a další

Zdroj: FEBS Open Bio
FEBS Open Bio, Vol 12, Iss 2, Pp 500-515 (2022)

Témata: 0301 basic medicine, 0303 health sciences, computational approach, QH301-705.5, Computational Biology, Inflammatory Bowel Diseases, 3. Good health, leukocyte migration, Mice, 03 medical and health sciences, RAW 264.7 Cells, bioassay, Animals, Colitis, Ulcerative, Biology (General), immune‐related biomarkers, Research Articles, Biomarkers, ulcerative colitis

Přístupová URL adresa: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.13357
https://pubmed.ncbi.nlm.nih.gov/34939750
https://doaj.org/article/e8ff43ed2a014cf5883ca66e91511aa4

An integrative computational approach to effectively guide experimental identification of regulatory elements in promoters

Autoři: Deyneko, Igor V Weiss, Siegfried Leschner, Sara a další

Přispěvatelé: Deyneko, Igor V Weiss, Siegfried Leschner, Sara a další

Zdroj: BMC Bioinformatics
BMC Bioinformatics, Vol 13, Iss 1, p 202 (2012)

Témata: 0301 basic medicine, 0303 health sciences, QH301-705.5, Methodology Article, Computer applications to medicine. Medical informatics, R858-859.7, Computational Biology, Gene Expression, Sequence Analysis, DNA, DNA motifs, Biochemistry, Cis-regulatory modules, Computer Science Applications, 03 medical and health sciences, Transcriptional regulation, Salmonella, Neoplasms, Biology (General), Nucleotide Motifs, Promoter Regions, Genetic, Molecular Biology, Algorithms

Přístupová URL adresa: https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/1471-2105-13-202
https://pubmed.ncbi.nlm.nih.gov/22897887
https://doaj.org/article/70767cef956c4475b5d6b949ef8c58b4
https://dblp.uni-trier.de/db/journals/bmcbi/bmcbi13.html#DeynekoWL12
https://www.biomedcentral.com/1471-2105/13/202
http://core.ac.uk/display/26589487
https://0-bmcbioinformatics-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2105-13-202
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-13-202
https://link.springer.com/article/10.1186/1471-2105-13-202
http://hdl.handle.net/10033/298245

Target identification and mechanism elucidation of Chai Hu Shu Gan-San against the comorbidity of insomnia and depression based on integrative computational pharmacology.

Autoři: Murthy, Meesala Krishna

Zdroj: Network Modeling & Analysis in Health Informatics & Bioinformatics; 11/20/2025, Vol. 14 Issue 1, p1-19, 19p

Integrative modeling of membrane-associated protein assemblies

Autoři: Jorge Roel-Touris Brian Jiménez-García Alexandre M.J.J. Bonvin a další

Přispěvatelé: Jorge Roel-Touris Brian Jiménez-García Alexandre M.J.J. Bonvin a další

Zdroj: Nat Commun
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Témata: 0301 basic medicine, 0303 health sciences, Protein Conformation, Science, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy, Computational Biology, Membrane Proteins, Reproducibility of Results, General Chemistry, Article, Molecular Docking Simulation, 03 medical and health sciences, Databases, Protein, Algorithms, Software, Protein Binding

Popis souboru: application/pdf

Přístupová URL adresa: https://www.nature.com/articles/s41467-020-20076-5.pdf
https://www.biorxiv.org/content/biorxiv/early/2020/07/21/2020.07.20.211987.full.pdf
https://pubmed.ncbi.nlm.nih.gov/33277503
https://doaj.org/article/ddecf94631954d58846ce015c43e0b7e
https://pubmed.ncbi.nlm.nih.gov/33277503/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718903
https://www.ncbi.nlm.nih.gov/pubmed/33277503
https://www.nature.com/articles/s41467-020-20076-5
https://ui.adsabs.harvard.edu/abs/2020NatCo..11.6210R/abstract
https://www.nature.com/articles/s41467-020-20076-5.pdf
https://www.biorxiv.org/content/biorxiv/early/2020/07/21/2020.07.20.211987.full.pdf
https://www.biorxiv.org/content/10.1101/2020.07.20.211987v1.full.pdf+html
https://www.biorxiv.org/content/10.1101/2020.07.20.211987v1
https://dspace.library.uu.nl/handle/1874/410984

Food-derived linear vs. rationally designed cyclic peptides as potent TNF-alpha inhibitors: an integrative computational study.

Autoři: Shah, Manisha Arumugam, Sivakumar

Zdroj: Frontiers in Bioinformatics; 2025, p1-29, 29p

An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer

Autoři: Stefania Bortoluzzi Edoardo D'Angelo Isacco Maretto a další

Přispěvatelé: Stefania Bortoluzzi Edoardo D'Angelo Isacco Maretto a další

Zdroj: Oncotarget. 6:32561-32574

Témata: 0301 basic medicine, Biological network, Drug Resistance, Integrated approach, Predictive, Prognostic, Rectal cancer, Algorithms, Biomarkers, Tumor, Chemoradiotherapy, Adjuvant, Computational Biology, Databases, Genetic, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Genetic Predisposition to Disease, Humans, Multivariate Analysis, Neoadjuvant Therapy, Patient Selection, Phenotype, Precision Medicine, Predictive Value of Tests, Rectal Neoplasms, Risk Factors, Survival Analysis, Systems Integration, Time Factors, Treatment Outcome, Gene Expression Profiling, Oncology, Predictive Value of Test, 0302 clinical medicine, Multivariate Analysi, Adjuvant, Tumor, Gene Regulatory Network, Chemoradiotherapy, 3. Good health, Algorithm, Survival Analysi, Human, Time Factor, Databases, 03 medical and health sciences, Genetic, Neoplastic, Rectal Neoplasm, Risk Factor, Gene Expression Regulation, 13. Climate action, Neoplasm, Biomarkers

Popis souboru: application/pdf

Přístupová URL adresa: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=4935&path%5B%5D=16233
https://pubmed.ncbi.nlm.nih.gov/26359356
https://iris.unive.it/handle/10278/3682992
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=4935&path%5B%5D=16233
https://iris.unive.it/bitstream/10278/3682992/1/45.pdf
https://core.ac.uk/display/53520598
https://mediatum.ub.tum.de/1321427
https://www.research.unipd.it/handle/11577/3166703
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path[]=4935&path[]=13376
https://hdl.handle.net/11365/997465
https://doi.org/10.18632/oncotarget.4935
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path[]=4935&path[]=13376
https://hdl.handle.net/10278/3682992
https://doi.org/10.18632/oncotarget.4935