Výsledky vyhledávání - Graph Theory—graph algorithms*

Zdroj: Suleyman Demirel University Faculty of Arts & Science Journal of Science / Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi; 2025, Vol. 20 Issue 1, p63-74, 12p

Témata: GRAPH algorithms, HYPERBOLIC spaces, GRAPH theory, ALGORITHMS

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20

Effective Treatment of Drug-Resistant Cancers (Pancreatic, Glioblastoma, Metastatic) — Vaccine and Drug Development through the Hamzah Model

Autoři: JALALI, SEYED RASOUL

Témata: cancer, oncology, drug resistance, multidrug resistance, tumour heterogeneity, pancreatic cancer, glioblastoma, metastatic cancer, resistant tumours, adaptive resistance, tumour relapse, chemotherapy, radiotherapy, immunotherapy, targeted therapy, nanomedicine, nanotechnology, nanoparticle drug delivery, liposomal delivery, lipid nanoparticles, PLGA nanoparticles, PEGylated nanoparticles, controlled release, targeted release, tumour microenvironment, hypoxia, angiogenesis, vascularisation, tumour stem cells, immune evasion, T–cell activation, CTL response, Th1 induction, immune checkpoint inhibition, PD–1, PD–L1, CTLA–4, CAR–T therapy, NK cells, macrophages, dendritic cells, adaptive immunity, innate immunity, cytokines, interleukins, interferons, chemokines, tumour–associated macrophages, tumour infiltrating lymphocytes, tumour–associated fibroblasts, stromal interactions, tumour signalling, EGFR resistance, PI3K/AKT pathway, MAPK pathway, mTOR signalling, tyrosine kinase inhibition, DNA repair mechanisms, homologous recombination, non–homologous end joining, mismatch repair, DNA repair overdrive, genomic instability, chromosomal instability, mutational landscape, oncogenic mutations, tumour suppressor loss, TP53, BRCA1, BRCA2, KRAS, NRAS, BRAF, EGFR mutations, HER2 amplification, MYC activation, cell cycle dysregulation, apoptosis evasion, senescence bypass, autophagy regulation, metabolic rewiring, Warburg effect, glycolysis, oxidative phosphorylation, mitochondrial dysfunction, lactate export, pH regulation, proton transporters, ion channels, tumour acidity, ROS signalling, redox balance, antioxidant defences, glutathione, thioredoxin, peroxiredoxin, ferroptosis, necroptosis, pyroptosis, cell death pathways, fractional calculus, fractal derivatives, fractional order models, complex integration, multiscale integration, matter–energy transformation, quantum biology, quantum noise, stochastic modelling, chaos theory, bifurcation analysis, attractors, strange attractors, phase transitions, metastability, dynamic equilibrium, complex adaptive systems, systems biology, integrative modelling, computational oncology, mathematical oncology, bioinformatics, omics integration, genomics, transcriptomics, proteomics, metabolomics, epigenomics, pharmacogenomics, pharmacokinetics, pharmacodynamics, PK–PD modelling, absorption, distribution, metabolism, excretion, clearance, plasma volume, bioavailability, half–life, dose–response, EC50, IC50, Emax, Hill coefficient, drug synergy, drug antagonism, combination therapy, polytherapy, cocktail therapy, adaptive dosing, dose escalation, therapeutic window, therapeutic index, off–target effects, side effect minimisation, toxicity reduction, safety margin, quality of life, survival rate, progression–free survival, overall survival, relapse–free survival, clinical trials, preclinical trials, in vivo models, in vitro models, xenografts, organoids, patient–derived xenografts, spheroids, co–culture systems, 3D models, microfluidics, lab–on–chip, organ–on–chip, bioreactors, lyophilisation, freeze drying, nanofabrication, nanocarriers, smart nanoparticles, responsive nanoparticles, stimuli–responsive release, pH–sensitive release, temperature–sensitive release, redox–sensitive release, enzyme–sensitive release, targeted ligands, antibodies, aptamers, peptides, folate targeting, transferrin targeting, EGFR targeting, HER2 targeting, integrins, RGD peptides, nuclear localisation, mitochondrial targeting, lysosomal escape, endosomal release, exosomes, extracellular vesicles, vesicular trafficking, clathrin mediated endocytosis, caveolin mediated endocytosis, macropinocytosis, receptor mediated endocytosis, intracellular trafficking, pharmacological modelling, biophysics, thermodynamics, statistical mechanics, entropy, enthalpy, free energy, Gibbs free energy, Helmholtz free energy, partition functions, state transitions, molecular dynamics, Monte Carlo simulations, lattice models, Ising model, spin systems, neural networks, deep learning, convolutional neural networks, recurrent neural networks, reinforcement learning, generative adversarial networks, variational autoencoders, XGBoost, random forest, decision trees, ensemble learning, predictive modelling, classification, regression, clustering, dimensionality reduction, PCA, t–SNE, UMAP, feature engineering, feature selection, biomarkers, predictive biomarkers, prognostic biomarkers, diagnostic biomarkers, liquid biopsy, circulating tumour DNA, circulating tumour cells, exosomal RNA, tumour markers, CA19–9, CEA, AFP, PSA, CA125, imaging biomarkers, radiomics, PET imaging, MRI, CT imaging, functional imaging, diffusion weighted imaging, perfusion imaging, metabolic imaging, nuclear imaging, image–guided therapy, image processing, signal processing, time series analysis, Fourier analysis, Laplace transforms, fractional Laplacian, differential equations, partial differential equations, integro–differential equations, fractional differential equations, boundary conditions, initial conditions, stability criteria, numerical analysis, discretisation, finite element analysis, spectral methods, operator theory, eigenvalues, eigenvectors, Hilbert space, Banach space, functional analysis, operator semigroups, semigroup theory, stochastic differential equations, Ito calculus, Stratonovich calculus, Langevin dynamics, Fokker–Planck equation, Kolmogorov equations, path integrals, quantum field theory, string theory, cosmological models, general relativity, special relativity, spacetime curvature, energy density, dark matter, dark energy, entropy flow, holographic principle, quantum entanglement, decoherence, superposition, wavefunction collapse, Schrödinger equation, Dirac equation, Heisenberg uncertainty, Planck constant, Boltzmann constant, Avogadro constant, dimensional analysis, scaling laws, renormalisation group, universality, critical phenomena, nonlinearity, nonlocality, long–range interactions, fractional Brownian motion, Lévy flights, anomalous diffusion, subdiffusion, superdiffusion, percolation theory, fractal geometry, Hausdorff dimension, Minkowski dimension, Cantor sets, Sierpinski structures, Koch curve, fractal networks, scale–free networks, small–world networks, network theory, graph theory, adjacency matrices, Laplacian matrices, spectral graph theory, network robustness, percolation threshold, epidemics on networks, cancer networks, signalling networks, metabolic networks, gene regulatory networks, protein–protein interaction networks, immune networks, dynamical networks, multiscale networks, hierarchical clustering, modularity, community detection, information theory, Shannon entropy, mutual information, Kullback–Leibler divergence, Jensen–Shannon divergence, complexity theory, algorithmic complexity, Kolmogorov complexity, Turing machines, computational complexity, NP–hard problems, optimisation, convex optimisation, non–convex optimisation, gradient descent, stochastic gradient descent, Adam optimiser, evolutionary algorithms, genetic algorithms, particle swarm optimisation, ant colony optimisation, simulated annealing, Bayesian optimisation, Markov chain Monte Carlo, Gibbs sampling, variational inference, probabilistic programming, causal inference, counterfactual analysis, sensitivity analysis, robustness analysis, uncertainty quantification, error propagation, variance reduction, surrogate modelling, reduced order models, high performance computing, parallel computing, distributed computing, GPU acceleration, CUDA programming, MPI, OpenMP, quantum computing, quantum algorithms, Grover's algorithm, Shor's algorithm, quantum annealing, quantum machine learning, hybrid quantum–classical models, future contingencies, scenario planning, stress testing, resilience modelling, adaptive systems, evolutionary dynamics, co–evolution, arms race, predator–prey models, ecological modelling, fitness landscapes, landscape ruggedness, adaptive peaks, valley crossing, tumour evolution, clonal evolution, immune surveillance, immune escape, therapeutic resistance, evolutionary game theory, replicator dynamics, Nash equilibria, evolutionary stable strategies, cancer ecosystems, tumour ecology, competition, cooperation, parasitism, resource allocation, niche construction, tumour dormancy, relapse mechanisms, latency, minimal residual disease, eradication thresholds, cure probability, survival probability, remission, remission durability, patient stratification, personalised medicine, precision medicine, systems oncology, integrative oncology, translational oncology, computational biomedicine, mathematical medicine, fractal oncology, ψ–Hamzah Equation, Hamzah model, Seyed Rasoul Jalali, ψ–Hamzah multiscale framework, ψ–Hamzah fractional–fractal derivative, ψ–Hamzah complex integration, ψ–Hamzah cancer resistance model, ψ–Hamzah pharmacokinetics, ψ–Hamzah pharmacodynamics, ψ–Hamzah adaptive dosing, ψ–Hamzah entropy analysis, ψ–Hamzah intelligence index, ψ–Hamzah validation, ψ–Hamzah field simulation, ψ–Hamzah therapeutic design, ψ–Hamzah vaccine, ψ–Hamzah drug, ψ–Hamzah intellectual property, ψ–Hamzah universal cure

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Výsledky vyhledávání - Graph Theory—graph algorithms*

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