Výsledky vyhľadávania - Genetic and Environmental Risk in AD/Defining Genetic

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Autori: Kunkle, Brian W. Grenier-Boley, Benjamin Sims, Rebecca a ďalší

Prispievatelia: Kunkle, Brian W. Grenier-Boley, Benjamin Sims, Rebecca a ďalší

Zdroj: NATURE GENETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Nature genetics 51(3), 414-430 (2019). doi:10.1038/s41588-019-0358-2
Nature genetics
Kunkle, B W, Grenier-Boley, B, Sims, R, Bis, J C, Damotte, V, Naj, A C, Boland, A, Vronskaya, M, van der Lee, S J, Amlie-Wolf, A, Bellenguez, C, Frizatti, A, Chouraki, V, Martin, E R, Sleegers, K, Badarinarayan, N, Jakobsdottir, J, Hamilton-Nelson, K L, Moreno-Grau, S, Olaso, R, Raybould, R, Chen, Y, Kuzma, A B, Hiltunen, M, Morgan, T, Ahmad, S, Vardarajan, B N, Epelbaum, J, Hoffmann, P, Boada, M, Beecham, G W, Garnier, J G, Harold, D, Fitzpatrick, A L, Valladares, O, Moutet, M L, Gerrish, A, Smith, A V, Qu, L, Bacq, D, Denning, N, Jian, X, Zhao, Y, Del Zompo, M, Fox, N C, Choi, S H, Mateo, I, Hughes, J T, Adams, H H, Malamon, J, Sanchez-Garcia, F, Patel, Y, Brody, J A, Dombroski, B A, Naranjo, M C D, Daniilidou, M, Eiriksdottir, G, Mukherjee, S, Wallon, D, Uphill, J, Aspelund, T, Cantwell, L B, Garzia, F, Galimberti, D, Hofer, E, Butkiewicz, M, Fin, B, Scarpini, E, Sarnowski, C, Bush, W S, Meslage, S, Kornhuber, J, White, C C, Song, Y, Barber, R C, Engelborghs, S, Sordon, S, Voijnovic, D, Adams, P M, Vandenberghe, R, Mayhaus, M, Cupples, L A, Albert, M S, De Deyn, P P, Gu, W, Himali, J J, Beekly, D, Squassina, A, Hartmann, A M, Orellana, A, Blacker, D, Rodriguez-Rodriguez, E, Lovestone, S, Garcia, M E, Doody, R S, Munoz-Fernadez, C, Sussams, R, Lin, H, Fairchild, T J, Benito, Y A, Holmes, C, Karamujić-Čomić, H, Frosch, M P, Thonberg, H, Maier, W, Roschupkin, G, Ghetti, B, Giedraitis, V, Kawalia, A, Li, S, Huebinger, R M, Kilander, L, Moebus, S, Hernández, I, Kamboh, M I, Brundin, R M, Turton, J, Yang, Q, Katz, M J, Concari, L, Lord, J, Beiser, A S, Keene, C D, Helisalmi, S, Kloszewska, I, Kukull, W A, Koivisto, A M, Lynch, A, Tarraga, L, Larson, E B, Haapasalo, A, Lawlor, B, Mosley, T H, Lipton, R B, Solfrizzi, V, Gill, M, Longstreth, W T, Montine, T J, Frisardi, V, Diez-Fairen, M, Rivadeneira, F, Petersen, R C, Deramecourt, V, Alvarez, I, Salani, F, Ciaramella, A, Boerwinkle, E, Reiman, E M, Fievet, N, Rotter, J I, Reisch, J S, Hanon, O, Cupidi, C, Andre Uitterlinden, A G, Royall, D R, Dufouil, C, Maletta, R G, de Rojas, I, Sano, M, Brice, A, Cecchetti, R, George-Hyslop, P S, Ritchie, K, Tsolaki, M, Tsuang, D W, Dubois, B, Craig, D, Wu, C K, Soininen, H, Avramidou, D, Albin, R L, Fratiglioni, L, Germanou, A, Apostolova, L G, Keller, L, Koutroumani, M, Arnold, S E, Panza, F, Gkatzima, O, Asthana, S, Hannequin, D, Whitehead, P, Atwood, C S, Caffarra, P, Hampel, H, Quintela, I, Carracedo, Á, Lannfelt, L, Rubinsztein, D C, Barnes, L L, Pasquier, F, Frölich, L, Barral, S, McGuinness, B, Beach, T G, Johnston, J A, Becker, J T, Passmore, P, Bigio, E H, Schott, J M, Bird, T D, Warren, J D, Boeve, B F, Lupton, M K, Bowen, J D, Proitsi, P, Boxer, A, Powell, J F, Burke, J R, Kauwe, J S K, Burns, J M, Mancuso, M, Buxbaum, J D, Bonuccelli, U, Cairns, N J, McQuillin, A, Cao, C, Livingston, G, Carlson, C S, Bass, N J, Carlsson, C M, Hardy, J, Carney, R M, Bras, J, Carrasquillo, M M, Guerreiro, R, Allen, M, Chui, H C, Fisher, E, Masullo, C, Crocco, E A, DeCarli, C, Bisceglio, G, Dick, M, Ma, L, Duara, R, Graff-Radford, N R, Evans, D A, Hodges, A, Faber, K M, Scherer, M, Fallon, K B, Riemenschneider, M, Fardo, D W, Heun, R, Farlow, M R, Kölsch, H, Ferris, S, Leber, M, Foroud, T M, Heuser, I, Galasko, D R, Giegling, I, Gearing, M, Hüll, M, Geschwind, D H, Gilbert, J R, Morris, J C, Green, R C, Mayo, K, Growdon, J H, Feulner, T, Hamilton, R L, Harrell, L E, Drichel, D, Honig, L S, Cushion, T D, Huentelman, M J, Hollingworth, P, Hulette, C M, Hyman, B T, Marshall, R, Jarvik, G P, Meggy, A, Abner, E, Menzies, G E, Jin, L W, Leonenko, G, Real, L M, Jun, G R, Baldwin, C T, Grozeva, D, Karydas, A, Russo, G, Kaye, J A, Kim, R, Jessen, F, Kowall, N W, Vellas, B, Kramer, J H, Vardy, E, LaFerla, F M, Jöckel, K H, Lah, J J, Dichgans, M, Leverenz, J B, Mann, D, Levey, A I, Pickering-Brown, S, Lieberman, A P, Klopp, N, Lunetta, K L, Wichmann, H E, Lyketsos, C G, Morgan, K, Marson, D C, Brown, K, Martiniuk, F, Medway, C, Mash, D C, Nöthen, M M, Masliah, E, Hooper, N M, McCormick, W C, Daniele, A, McCurry, S M, Bayer, A, McDavid, A N, Gallacher, J, McKee, A C, van den Bussche, H, Mesulam, M, Brayne, C, Miller, B L, Riedel-Heller, S, Miller, C A, Miller, J W, Al-Chalabi, A, Morris, J C, Shaw, C E, Myers, A J, Wiltfang, J, O’Bryant, S, Olichney, J M, Alvarez, V, Parisi, J E, Singleton, A B, Paulson, H L, Collinge, J, Perry, W R, Mead, S, Peskind, E, Cribbs, D H, Rossor, M, Pierce, A, Ryan, N S, Poon, W W, Nacmias, B, Potter, H, Sorbi, S, Quinn, J G, Sacchinelli, E, Raj, A, Spalletta, G, Raskind, M, Caltagirone, C, Bossù, P, Orfei, M D, Reisberg, B, Clarke, R, Reitz, C, Smith, A D, Ringman, J M, Warden, D, Roberson, E D, Wilcock, G, Rogaeva, E, Bruni, A C, Rosen, H J, Gallo, M, Rosenberg, R N, Ben-Shlomo, Y, Sager, M A, Mecocci, P, Saykin, A J, Pastor, P, Cuccaro, M L, Vance, J M, Schneider, J A, Schneider, L S, Slifer, S, Seeley, W W, Smith, A G, Sonnen, J A, Spina, S, Stern, R A, Swerdlow, R H, Tang, M, Tanzi, R E, Trojanowski, J Q, Troncoso, J C, Van Deerlin, V M, Van Eldik, L J, Vinters, H V, Vonsattel, J P, Weintraub, S, Welsh-Bohmer, K A, Wilhelmsen, K C, Williamson, J, Wingo, T S, Woltjer, R L, Wright, C B, Yu, C E, Yu, L, Saba, Y, Pilotto, A, Bullido, M J, Peters, O, Crane, P K, Bennett, D, Bosco, P, Coto, E, Boccardi, V, De Jager, P L, Lleo, A, Warner, N, Lopez, O L, Ingelsson, M, Deloukas, P, Cruchaga, C, Graff, C, Gwilliam, R, Fornage, M, Goate, A M, Sanchez-Juan, P, Kehoe, P G, Amin, N, Ertekin-Taner, N, Berr, C, Debette, S, Love, S, Launer, L J, Younkin, S G, Dartigues, J F, Corcoran, C, Ikram, M A, Dickson, D W, Nicolas, G, Campion, D, Tschanz, J A, Schmidt, H, Hakonarson, H, Clarimon, J, Munger, R, Schmidt, R, Farrer, L A, Van Broeckhoven, C, C. O’Donovan, M, DeStefano, A L, Jones, L, Haines, J L, Deleuze, J F, Owen, M J, Gudnason, V, Mayeux, R, Escott-Price, V, Psaty, B M, Ramirez, A, Wang, L S, Ruiz, A, van Duijn, C M, Holmans, P A, Seshadri, S, Williams, J, Amouyel, P, Schellenberg, G D, Lambert, J C & Pericak-Vance, M A 2019, ' Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing ', Nature Genetics, vol. 51, no. 3, pp. 414-430 . https://doi.org/10.1038/s41588-019-0358-2
2019, 'Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing', Nature Genetics, vol. 51, no. 3, pp. 414-430. https://doi.org/10.1038/s41588-019-0358-2
Alzheimer Disease Genetics Consortium (ADGC), European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES) 2019, 'Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing', Nature Genetics, vol. 51, no. 3, pp. 414-430. https://doi.org/10.1038/s41588-019-0358-2
Nature genetics, vol 51, iss 3
Nature Genetics, vol 51, iss 3

Predmety: Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Male, 0301 basic medicine, Genetic and Environmental Risk in AD/Defining Genetic, Aging, Amyloid beta-Peptide, Medizin, Gene Expression, genetics [Alzheimer Disease], Neurodegenerative, Alzheimer's Disease, methods [Genome-Wide Association Study], Medical and Health Sciences, SEPIA, name=Cerebrovascular and Dementia Research Group, genetics [Immunity], Haplotype, 2.1 Biological and endogenous factors, genetics [Amyloid beta-Peptides], genetics, Aetiology, genetics [Genetic Predisposition to Disease], ResearchInstitutes_Networks_Beacons/MICRA, name=Manchester Institute for Collaborative Research on Ageing, ddc:610, 0303 health sciences, Human leukocyte antigen, Lipid, Biological Sciences, Alzheimer's disease, Bioinformatics and computational biology, Lipids, EMC NIHES-03-30-02, 3. Good health, VINTAGE, Manchester Institute for Collaborative Research on Ageing, Neurological, Female, Case-Control Studie, Human, EMC NIHES-01-64-02, European Alzheimer's Disease Initiative (EADI), methods [Genetic Testing], Agricultural biotechnology, Alzheimerkrankheit, tau Proteins, genetics [Genetic Loci], FR, 03 medical and health sciences, Clinical Research, Alzheimer Disease, ddc:570, genetics [Haplotypes], Polygenic and Environmental Risk for Alzheimer's Disease Consortium (GERAD/PERADES), Acquired Cognitive Impairment, Genetics, Humans, Genetic Predisposition to Disease, LOAD, Genetic Testing, meta-analysis Alzheimer's disease risk loci, genetics [Lipids], genetic meta-analysis, new risk loci, Aβ, tau, immunity, lipid processing, Biology, Aged, Amyloid beta-Peptides, Prevention, Inflammatory and immune system, Human Genome, Neurosciences, Immunity, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Lipid Metabolism, Gene expression, Genome-wide association studies, name=SDG 3 - Good Health and Well-being, Brain Disorders, genetics [tau Proteins], Haplotypes, Alzheimer Disease Genetics Consortium (ADGC), [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Genetic Loci, Case-Control Studies, genome-wide association studies, genetics [Lipid Metabolism], EMC MM-01-39-09-A, Dementia, Biochemistry and Cell Biology, Human medicine, Developmental Biology, dementia, Genome-Wide Association Study

Popis súboru: application/pdf

Prístupová URL adresa: https://europepmc.org/articles/pmc6463297?pdf=render
https://pubmed.ncbi.nlm.nih.gov/30820047
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2946
https://europepmc.org/articles/pmc6463297
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2946
https://orca.cardiff.ac.uk/id/eprint/120904/1/IGAP_GWAS_Article_revision1.pdf
https://digitalcommons.psjhealth.org/publications/1131/
https://researchportal.vub.be/en/publications/genetic-meta-analysis-of-diagnosed-alzheimers-disease-identifies-
https://www.cardioscience.ox.ac.uk/publications/979085
https://miami.pure.elsevier.com/en/publications/genetic-meta-analysis-of-diagnosed-alzheimers-disease-identifies-
https://escholarship.org/content/qt3j77j7p5/qt3j77j7p5.pdf?t=qjqbx5
https://pubmed.ncbi.nlm.nih.gov/30820047/
https://resolver.sub.uni-goettingen.de/purl?gro-2/73835
https://hdl.handle.net/10067/1579230151162165141
https://hdl.handle.net/10807/134467
https://doi.org/10.1038/s41588-019-0358-2
https://pure.qub.ac.uk/en/publications/genetic-metaanalysis-of-diagnosed-alzheimers-disease-identifies-new-risk-loci-and-implicates-a-tau-immunity-and-lipid-processing(d9e9b555-4b8a-4262-a4ba-460b2dd62d13).html
https://hdl.handle.net/10668/27609
https://research-information.bris.ac.uk/ws/files/186560986/IGAP_GWAS_Article_revision.pdf
https://hdl.handle.net/1983/6c74ba85-ff39-4ff0-afe0-47d331843129
https://hal.science/hal-03209563v1
https://doi.org/10.1038/s41588-019-0358-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297/
https://doi.org/10.1038/s41588-019-0358-2
https://hdl.handle.net/11391/1458971
https://discovery-pp.ucl.ac.uk/id/eprint/10071668/
https://escholarship.org/uc/item/3j77j7p5
https://escholarship.org/content/qt76h3d5wd/qt76h3d5wd.pdf
https://escholarship.org/uc/item/76h3d5wd

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Autori: Kunkle, Brian W Grenier-Boley, Benjamin Sims, Rebecca a ďalší

Zdroj: Nature Genetics. 51(9)

Predmety: Biochemistry and Cell Biology, Biological Sciences, Brain Disorders, Prevention, Neurodegenerative, Aging, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Genetics, Alzheimer's Disease, Dementia, Neurosciences, Clinical Research, Alzheimer Disease Genetics Consortium, European Alzheimer’s Disease Initiative, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/2cr1c90z
https://escholarship.org/content/qt2cr1c90z/qt2cr1c90z.pdf

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Autori: Kunkle, BW Grenier-Boley, B Sims, R a ďalší

Predmety: 3101 Biochemistry and Cell Biology, 31 Biological Sciences, 3105 Genetics, 4202 Epidemiology, 42 Health Sciences, Dementia, Acquired Cognitive Impairment, Brain Disorders, Neurodegenerative, Clinical Research, Biotechnology, Genetics, Alzheimer's Disease, Neurosciences, Human Genome, Prevention, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, 2.1 Biological and endogenous factors, Neurological

Popis súboru: application/pdf

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Dostupnosť: https://www.repository.cam.ac.uk/handle/1810/289663
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