Search Results - Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models*

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Authors: Aslak Tveito Glenn T. Lines

Resource Type: eBook.

Subjects: Computer science--Mathematics, Computer graphics, Mathematics

Categories: MATHEMATICS / Applied, COMPUTERS / Image Processing, COMPUTERS / Computer Science, COMPUTERS / Artificial Intelligence / Computer Vision & Pattern Recognition, MEDICAL / Research

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Authors: Tveito, Aslak Lines, Glenn T.

Subject Terms: Computational Science and Engineering, Biomedicine general, Computer Imaging, Vision, Pattern Recognition and Graphics, Management of specific areas, Energy industries and utilities, Information technology industries, Medical equipment and techniques, Earth Sciences, Geography, Environment, Planning, History of engineering and technology, Biochemical engineering, Collecting coins, banknotes, medals and other related items

File Description: application/pdf

Relation: Lecture Notes in Computational Science and Engineering

Access URL: http://library.oapen.org/handle/20.500.12657/28065

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Authors: Tveito, Aslak Lines, Glenn T.

Source: Lecture Notes in Computational Science and Engineering ISBN: 9783319300290

Subject Terms: thema EDItEUR::R Earth Sciences, Geography, Environment, Planning, Agentes neuroprotectores, Biomedicine general, thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNT Media, entertainment, information and communication industries::KNTX Information technology industries, Computer Imaging, Vision, Pattern Recognition and Graphics, thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques, thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering, Agentes nootrópicos, Computational Science and Engineering, thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities, thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology, Medicamentos, thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas, thema EDItEUR::W Lifestyle, Hobbies and Leisure::WC Antiques, vintage and collectables::WCF Collecting coins, banknotes, medals and other related items, Computer Imaging

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Access URL: https://link.springer.com/content/pdf/10.1007%2F978-3-319-30030-6.pdf
https://library.oapen.org/bitstream/20.500.12657/28065/1/1001929.pdf
https://directory.doabooks.org/handle/20.500.12854/28702
http://library.oapen.org/handle/20.500.12657/28065
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http://link.springer.com/book/10.1007/978-3-319-30030-6

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Authors: Tveito, Aslak. author. Lines, Glenn T. author. SpringerLink (Online service)

Index Terms: Mathematics., Computer graphics., Computer mathematics., Computational Science and Engineering., Biomedicine general., Computer Imaging, Vision, Pattern Recognition and Graphics., Text

URL: http://dspace.conacyt.gov.py/xmlui/handle/123456789/17009
Springer eBooks
Lecture Notes in Computational Science and Engineering, 1439-7358 ; 111
http://cicco.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-3-319-30030-6

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Authors: Tveito, Aslak Lines, Glenn T.

Subject Terms: Computational Science and Engineering, Biomedicine general, Computer Imaging, Vision, Pattern Recognition and Graphics, thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities, Business and Management::KN Industry and industrial studies::KNT Media, entertainment, information and communication industries::KNTX Information technology industries, thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques, thema EDItEUR::R Earth Sciences, Geography, Environment, Planning, thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology, Industrial processes::TC Biochemical engineering, thema EDItEUR::W Lifestyle, Hobbies and Leisure::WC Antiques, vintage and collectables::WCF Collecting coins, banknotes, medals and other related items

File Description: image/jpeg

Relation: Lecture Notes in Computational Science and Engineering; 1001929; OCN: 1083016050; http://library.oapen.org/handle/20.500.12657/28065; https://library.oapen.org/bitstream/20.500.12657/28065/1/1001929.pdf

Availability: http://library.oapen.org/handle/20.500.12657/28065
https://hdl.handle.net/20.500.12657/28065
https://directory.doabooks.org/handle/20.500.12854/28702
https://hdl.handle.net/20.500.12854/28702
https://library.oapen.org/bitstream/20.500.12657/28065/1/1001929.pdf

Optimizing experimental designs for model selection of ion channel drug-binding mechanisms.

Authors: Patten-Elliott, Frankie Lei, Chon Lok Preston, Simon P. et al.

Source: Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences; 3/1/2025, Vol. 383 Issue 2292, p1-19, 19p

Subject Terms: DOSAGE forms of drugs, ION channels, BIOLOGICAL systems, HUMAN genes, EXPERIMENTAL design

The Pentameric Ligand-Gated Ion Channel Family: A New Member of the Voltage Gated Ion Channel Superfamily?

Authors: Dubey, Aditi Baxter, Madison Hendargo, Kevin J. et al.

Source: International Journal of Molecular Sciences; May2024, Vol. 25 Issue 9, p5005, 20p

Subject Terms: LIGAND-gated ion channels, VOLTAGE-gated ion channels, ION channels, HIDDEN Markov models, VOLTAGE

Inhibitory Effects of Cenobamate on Multiple Human Cardiac Ion Channels and Possible Arrhythmogenic Consequences.

Authors: Mateias, Andreea Larisa Armasescu, Florian Amuzescu, Bogdan et al.

Source: Biomolecules (2218-273X); Dec2024, Vol. 14 Issue 12, p1582, 19p

Subject Terms: SEIZURES (Medicine), ACTION potentials, VENTRICULAR arrhythmia, ANTICONVULSANTS, PATHOLOGY, ION channels

Molecular permeation through large pore channels: computational approaches and insights.

Authors: Kumar, Deepak Harris, Andrew L. Luo, Yun Lyna

Source: Journal of Physiology; Aug2025, Vol. 603 Issue 15, p4163-4177, 15p

Subject Terms: MOLECULAR dynamics, MOLECULAR interactions, QUANTITATIVE research, EXPERIMENTAL design, PERMEABILITY, TRANSPORT theory, POROSITY, ION channels

Computational methods for unlocking the secrets of potassium channels: Structure, mechanism, and drug design.

Authors: Wang, Lingling Zhang, Qianqian Tong, Henry H. Y. et al.

Source: WIREs: Computational Molecular Science; Jan/Feb2024, Vol. 14 Issue 1, p1-32, 32p

Subject Terms: POTASSIUM channels, ION channels, DRUG design, ION transport (Biology), STATISTICAL mechanics, MOLECULAR dynamics, ACTION potentials, ATRIAL arrhythmias

DeepGANnel: Synthesis of fully annotated single molecule patch-clamp data using generative adversarial networks.

Authors: Ball, Sam T. M. Celik, Numan Sayari, Elaheh et al.

Source: PLoS ONE; 5/10/2022, Vol. 17 Issue 5, p1-18, 18p

Subject Terms: GENERATIVE adversarial networks, SINGLE molecules, ION channels, PROBABILISTIC generative models, HIDDEN Markov models, MACHINE learning, TIME series analysis

Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol.

Authors: Zhang, Shugang Lu, Weigang Yang, Fei et al.

Source: NPJ Systems Biology & Applications; 11/4/2022, Vol. 8 Issue 1, p1-17, 17p

Subject Terms: CINCHONA alkaloids, QUINIDINE, VENTRICULAR arrhythmia, MARKOV processes, ION channels, SYNDROMES

A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes.

Authors: Jæger, Karoline Horgmo Edwards, Andrew G. Giles, Wayne R. et al.

Source: PLoS Computational Biology; 8/12/2021, Vol. 17 Issue 8, p1-24, 24p, 4 Charts, 8 Graphs

Subject Terms: ION channels, MEMBRANE potential, POTASSIUM channels, MUSCLE cells, ARRHYTHMIA, MEMBRANE proteins, HEART beat, ADULTS

Biophysical Modeling of Cardiac Cells: From Ion Channels to Tissue.

Authors: Alonso, Sergio Alvarez-Lacalle, Enrique Bragard, Jean et al.

Source: Biophysica; Mar2025, Vol. 5 Issue 1, p5, 34p

Subject Terms: ATRIAL arrhythmias, ACTION potentials, ATRIAL flutter, BIOPHYSICS, VENTRICULAR fibrillation, ARRHYTHMIA

Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment.

Authors: Bharambe, Nikhil Li, Zhuowen Seiferth, David et al.

Source: Nature Communications; 4/5/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: LIGAND-gated ion channels, ION channels, LIPIDS, MOLECULAR dynamics

Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2.

Authors: Fehrentz, Timm Amin, Ehsan Görldt, Nicole et al.

Source: British Journal of Pharmacology; Mar2025, Vol. 182 Issue 5, p1125-1142, 18p

Subject Terms: OPTICAL control, ELECTROPHYSIOLOGY, VOLTAGE-gated ion channels, VENTRICULAR arrhythmia, CHROMOPHORES synthesis, OPTOGENETICS, ELECTRIC countershock

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.

Authors: Zhou, Xin Qu, Yusheng Passini, Elisa et al.

Source: Frontiers in Pharmacology; 1/30/2020, Vol. 10, p1-17, 17p

Subject Terms: ION channels, CLINICAL drug trials, PHARMACOLOGY, RISK assessment, VENTRICULAR arrhythmia, CARDIAC amyloidosis

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering.

Authors: Lycksell, Marie Rovšnik, Urška Bergh, Cathrine et al.

Source: Proceedings of the National Academy of Sciences of the United States of America; 9/14/2021, Vol. 118 Issue 37, p1-9, 9p

Subject Terms: LIGAND-gated ion channels, SMALL-angle neutron scattering, ION channels, NEUTRON sources, CRYSTAL structure

Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors.

Authors: Dutta, Soumajit Shukla, Diwakar

Source: Communications Biology; 5/5/2023, Vol. 6 Issue 1, p1-16, 16p

Subject Terms: CANNABINOID receptors, METASTABLE states, LIGAND binding (Biochemistry), MARKOV processes

Limits on the computational expressivity of non-equilibrium biophysical processes.

Authors: Floyd, Carlos Dinner, Aaron R. Murugan, Arvind et al.

Source: Nature Communications; 8/5/2025, Vol. 16 Issue 1, p1-12, 12p

Subject Terms: NONEQUILIBRIUM thermodynamics, CLASSIFICATION, BIOLOGICAL networks, ENZYMES, MARKOVIAN jump linear systems, THERMODYNAMICS