Suchergebnisse - "virus replication"

Anticodon Engineered Transfer RNA (tRNA ^SUAG ) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein.

Autoren: Yang X Sun H Luo Z et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e03534. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B virus*/genetics , Hepatitis B virus*/drug effects , Hepatitis B virus*/metabolism , Virus Replication*/genetics , Virus Replication*/drug effects , RNA, Transfer*/genetics , Viral Core Proteins*/metabolism , Viral Core Proteins*/genetics , Hepatitis B Core Antigens*/metabolism , Hepatitis B Core Antigens*/genetics, Humans ; Hep G2 Cells ; Antiviral Agents/pharmacology

Monkeypox virus induces ferroptosis to facilitate viral replication and promotes inflammatory responses.

Autoren: Chuai X Wang Y Wang C et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2522877. Date of Electronic Publication: 2025 Jul 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis* , Virus Replication* , Monkeypox virus*/physiology , Inflammation*/virology , Mpox, Monkeypox*/virology , Mpox, Monkeypox*/immunology, Animals ; Mice ; Humans ; Mice, Inbred C57BL ; Vaccinia virus/physiology ; Host-Pathogen Interactions ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2/genetics

High-efficiency inhibition of human adenovirus type 55 replication by CRISPR-Cas12a.

Autoren: Yu L Niu M Dong Z et al.

Quelle: The Journal of infection [J Infect] 2025 Nov; Vol. 91 (5), pp. 106650. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE

MeSH-Schlagworte: CRISPR-Cas Systems* , Adenoviruses, Human*/physiology , Adenoviruses, Human*/genetics , Adenoviruses, Human*/drug effects , Virus Replication*/drug effects , Virus Replication*/genetics , Antiviral Agents*/pharmacology, Humans ; Adenovirus Infections, Human/virology ; Endodeoxyribonucleases/genetics ; Bacterial Proteins ; CRISPR-Associated Proteins

Replication of two reoviruses in continuous cell lines derived from Diaphorina citri.

Autoren: Ghosh S Wu K Bonning BC

Quelle: Journal of invertebrate pathology [J Invertebr Pathol] 2025 Nov; Vol. 213, pp. 108421. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0014067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0805 (Electronic) Linking ISSN: 00222011 NLM ISO Abbreviation: J Invertebr Pathol Subsets: MEDLINE

MeSH-Schlagworte: Virus Replication*/physiology , Reoviridae*/physiology , Hemiptera*/virology, Animals ; Cell Line

SCR Organism: Diaphorina citri

Major vault protein inhibits CSFV replication by promoting cell apoptosis.

Autoren: Luo B Su N Quan Y et al.

Quelle: Veterinary microbiology [Vet Microbiol] 2025 Nov; Vol. 310, pp. 110745. Date of Electronic Publication: 2025 Oct 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Scientific Pub. Co Country of Publication: Netherlands NLM ID: 7705469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2542 (Electronic) Linking ISSN: 03781135 NLM ISO Abbreviation: Vet Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Classical Swine Fever Virus*/physiology , Virus Replication* , Apoptosis* , Vault Ribonucleoprotein Particles*/genetics , Vault Ribonucleoprotein Particles*/metabolism, Animals ; Swine ; Cell Line ; Classical Swine Fever/virology

Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia.

Autoren: Starr A Rathore S Daniali M et al.

Quelle: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2025 Oct 11; Vol. 20 (1), pp. 87. Date of Electronic Publication: 2025 Oct 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Receptor, Cannabinoid, CB2*/agonists , Microglia*/drug effects , Microglia*/virology , Microglia*/metabolism , Macrophages*/drug effects , Macrophages*/virology , Macrophages*/metabolism , Induced Pluripotent Stem Cells*/drug effects , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/virology , Cannabinoids*/pharmacology , Virus Replication*/drug effects , Virus Replication*/physiology , Cannabinoid Receptor Agonists*/pharmacology , HIV-1*/drug effects , HIV-1*/physiology, Humans ; Cells, Cultured ; HIV Infections ; Inflammation

Hydroxypropyl-Beta-Cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication by modulating intracellular lipid dynamics and preventing viral replication complex formation.

Autoren: Bezerra BB Macedo KVG Correa IA et al.

Quelle: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Oct; Vol. 191, pp. 118465. Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

MeSH-Schlagworte: Virus Replication*/drug effects , 2-Hydroxypropyl-beta-cyclodextrin*/pharmacology , SARS-CoV-2*/drug effects , SARS-CoV-2*/physiology , Antiviral Agents*/pharmacology, Chlorocebus aethiops ; Vero Cells ; Animals ; COVID-19 Drug Treatment ; Humans ; Cholesterol/metabolism ; COVID-19/virology

Host S100A6 inhibits ZIKV replication by degrading NS3 through lysosomal pathway.

Autoren: Peng J Zou W Zhou L et al.

Quelle: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2025 Oct 01; Vol. 15, pp. 1602743. Date of Electronic Publication: 2025 Oct 01 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Virus Replication* , Zika Virus*/physiology , Viral Nonstructural Proteins*/metabolism , Viral Nonstructural Proteins*/genetics , Lysosomes*/metabolism , S100 Calcium Binding Protein A6*/metabolism , S100 Calcium Binding Protein A6*/genetics , Host-Pathogen Interactions* , RNA Helicases*/metabolism , Serine Endopeptidases*/metabolism, Humans ; HeLa Cells ; Zika Virus Infection/virology ; Zika Virus Infection/metabolism ; Proteolysis ; Animals ; Vero Cells ; Viral Proteases ; Cell Cycle Proteins ; Nucleoside-Triphosphatase ; DEAD-box RNA Helicases

Corticosteroid Prednisolone and flavonoid Chrysin as drug candidates against SARS-CoV-2 replication: Computational and experimental findings.

Autoren: Kumar A Khatter R Trivedi A et al.

Quelle: Microbial pathogenesis [Microb Pathog] 2025 Oct; Vol. 207, pp. 107923. Date of Electronic Publication: 2025 Jul 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH-Schlagworte: SARS-CoV-2*/drug effects , SARS-CoV-2*/physiology , Flavonoids*/pharmacology , Flavonoids*/chemistry , Virus Replication*/drug effects , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , COVID-19 Drug Treatment* , Prednisolone*/pharmacology , Prednisolone*/chemistry, Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme 2/chemistry ; Protein Binding/drug effects ; Chlorocebus aethiops ; Vero Cells ; COVID-19/virology ; Virus Internalization/drug effects

The role of bromodomain-containing protein 4 in the replication human papillomavirus, apoptosis, proliferation and migration of cervical cancer cells.

Autoren: Wang L Li W Zhu X et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178261. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Uterine Cervical Neoplasms*/pathology , Uterine Cervical Neoplasms*/virology , Uterine Cervical Neoplasms*/metabolism , Apoptosis*/drug effects , Cell Movement*/drug effects , Transcription Factors*/metabolism , Nuclear Proteins*/metabolism , Human papillomavirus 16*/physiology , Human papillomavirus 16*/drug effects , Virus Replication*/drug effects, Humans ; Female ; Cell Proliferation/drug effects ; Animals ; Cell Cycle Proteins ; Mice ; Cell Line, Tumor ; Viral Load/drug effects ; Mice, Nude ; Papillomavirus Infections/virology ; Middle Aged ; HeLa Cells ; Human Papillomavirus Viruses ; Bromodomain Containing Proteins

Phosphatase PP2A promotes RTA dephosphorylation to impair KSHV lytic replication.

Autoren: Bai L Dong L Dong J et al.

Quelle: PLoS pathogens [PLoS Pathog] 2025 Dec 03; Vol. 21 (12), pp. e1013731. Date of Electronic Publication: 2025 Dec 03 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

MeSH-Schlagworte: Herpesvirus 8, Human*/physiology , Protein Phosphatase 2*/metabolism , Protein Phosphatase 2*/genetics , Virus Replication*/physiology , Immediate-Early Proteins*/metabolism , Immediate-Early Proteins*/genetics , Trans-Activators*/metabolism , Trans-Activators*/genetics, Humans ; Phosphorylation ; Gene Expression Regulation, Viral ; HEK293 Cells ; Virus Latency/physiology

An alphavirus vaccine development utilizing RNA replication-defective strategy.

Autoren: Zhang Z Huang J Li Z et al.

Quelle: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6282-6297. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH-Schlagworte: Virus Replication*/genetics , Viral Vaccines*/immunology , Viral Vaccines*/genetics , Viral Vaccines*/administration & dosage , Alphavirus*/immunology , Alphavirus*/genetics , Vaccine Development* , Alphavirus Infections*/prevention & control , Alphavirus Infections*/immunology , Alphavirus Infections*/virology , RNA, Viral*/genetics, Animals ; Mice ; Cell Line ; Encephalitis Virus, Venezuelan Equine/genetics ; Encephalitis Virus, Venezuelan Equine/immunology ; Viral Nonstructural Proteins/genetics ; Humans ; Disease Models, Animal ; RNA Replication

Chikungunya virus replicates in the human testis ex vivo and impacts peritubular myoid cells functional markers.

Autoren: Cartron M Ciesielski V Houzet L et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2587984. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: Virus Replication* , Chikungunya virus*/physiology , Testis*/virology , Testis*/cytology , Chikungunya Fever*/virology, Humans ; Male ; Biomarkers/metabolism ; Cytokines/metabolism ; Seminiferous Tubules/virology ; Seminiferous Tubules/cytology

Impact of cell type and species on RNA replication kinetics of Seoul virus.

Autoren: LaPointe AT Klimaj SD Kell AM

Quelle: The Journal of general virology [J Gen Virol] 2025 Dec; Vol. 106 (12).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Microbiology Society Country of Publication: England NLM ID: 0077340 Publication Model: Print Cited Medium: Internet ISSN: 1465-2099 (Electronic) Linking ISSN: 00221317 NLM ISO Abbreviation: J Gen Virol Subsets: MEDLINE

MeSH-Schlagworte: Virus Replication* , RNA, Viral*/genetics , RNA, Viral*/biosynthesis , Seoul virus*/physiology , Seoul virus*/genetics, Animals ; Humans ; Chlorocebus aethiops ; Vero Cells ; Rats ; Endothelial Cells/virology ; Kinetics ; Real-Time Polymerase Chain Reaction ; Epithelial Cells/virology ; Cell Line ; Genome, Viral ; RNA Replication

Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion.

Autoren: Okura T Nakai Y Kameya T et al.

Quelle: PLoS pathogens [PLoS Pathog] 2025 Dec 01; Vol. 21 (12), pp. e1013755. Date of Electronic Publication: 2025 Dec 01 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

MeSH-Schlagworte: Methyltransferases*/metabolism , Methyltransferases*/genetics , Virus Replication*/physiology , Immune Evasion* , Viral Matrix Proteins*/metabolism , Viral Matrix Proteins*/genetics , Viral Matrix Proteins*/immunology , Paramyxovirinae*, Humans ; Animals ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Host-Pathogen Interactions

Discovery of three small-molecule inhibitors targeting Ebolavirus genome replication and transcription.

Autoren: Easton V J McPhillie M Barr J et al.

Quelle: The Journal of general virology [J Gen Virol] 2025 Dec; Vol. 106 (12).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Microbiology Society Country of Publication: England NLM ID: 0077340 Publication Model: Print Cited Medium: Internet ISSN: 1465-2099 (Electronic) Linking ISSN: 00221317 NLM ISO Abbreviation: J Gen Virol Subsets: MEDLINE

MeSH-Schlagworte: Ebolavirus*/drug effects , Ebolavirus*/physiology , Ebolavirus*/genetics , Virus Replication*/drug effects , Antiviral Agents*/pharmacology , Antiviral Agents*/isolation & purification , Antiviral Agents*/chemistry , Transcription, Genetic*/drug effects , Genome, Viral*/drug effects , Small Molecule Libraries*/pharmacology, Humans ; Drug Discovery ; Animals ; Hemorrhagic Fever, Ebola/virology ; Hemorrhagic Fever, Ebola/drug therapy

Negative regulation of reassortant canine influenza virus replication and key site identification in porcine and ferret bronchial epithelial cell lines.

Autoren: Guo J Jung B Yoon SW et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2595767. Date of Electronic Publication: 2025 Nov 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Virus Replication* , Reassortant Viruses*/physiology , Reassortant Viruses*/genetics , Epithelial Cells*/virology , Influenza A Virus, H3N2 Subtype*/genetics , Influenza A Virus, H3N2 Subtype*/physiology, Animals ; Dogs ; Ferrets ; Swine ; Cell Line ; Orthomyxoviridae Infections/virology ; Orthomyxoviridae Infections/veterinary ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/physiology ; Bronchi/virology ; Bronchi/cytology ; Cytokines/metabolism

The natural polyphenol proanthocyanidin A2 prevents the in vitro infection of Ebola virus and rabies virus by interfering with the early phases of the replication cycle.

Autoren: Pasqual D Artusi I Paccagnella M et al.

Quelle: Antiviral research [Antiviral Res] 2025 Dec; Vol. 244, pp. 106312. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

MeSH-Schlagworte: Ebolavirus*/drug effects , Ebolavirus*/physiology , Antiviral Agents*/pharmacology , Proanthocyanidins*/pharmacology , Proanthocyanidins*/chemistry , Virus Replication*/drug effects , Rabies virus*/drug effects , Rabies virus*/physiology , Polyphenols*/pharmacology, Humans ; Animals ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Vaccinium macrocarpon/chemistry ; Virus Internalization/drug effects ; Molecular Docking Simulation ; Virus Attachment/drug effects ; Cell Line ; Viral Envelope Proteins/metabolism

Role of the urokinase-type plasminogen activator system in viral infection and replication.

Autoren: Yang S Chen J Shi X et al.

Quelle: Molecular immunology [Mol Immunol] 2025 Dec; Vol. 188, pp. 38-44. Date of Electronic Publication: 2025 Nov 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

MeSH-Schlagworte: Urokinase-Type Plasminogen Activator*/metabolism , Urokinase-Type Plasminogen Activator*/immunology , Virus Replication*/physiology , Virus Diseases*/immunology , Virus Diseases*/metabolism, Humans ; Receptors, Urokinase Plasminogen Activator/metabolism ; Receptors, Urokinase Plasminogen Activator/immunology ; Animals

Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication.

Autoren: Ma YX Yang JM Mei HT et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2585639. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Pentose Phosphate Pathway* , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics , Virus Replication* , Porcine respiratory and reproductive syndrome virus*/physiology , Glucosephosphate Dehydrogenase*/metabolism , Glucosephosphate Dehydrogenase*/genetics , Reactive Oxygen Species*/metabolism, Animals ; Swine ; Macrophages, Alveolar/virology ; Macrophages, Alveolar/metabolism ; Signal Transduction ; Porcine Reproductive and Respiratory Syndrome/virology ; Porcine Reproductive and Respiratory Syndrome/metabolism ; Host-Pathogen Interactions